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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">prmed</journal-id><journal-title-group><journal-title xml:lang="ru">Первичная медико-санитарная помощь</journal-title><trans-title-group xml:lang="en"><trans-title>Primary Health Care (Russian Federation)</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">3034-4123</issn><issn pub-type="epub">3034-4565</issn><publisher><publisher-name>LTD "Silicea-Poligraf"</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.15829/3034-4123-2026-153</article-id><article-id custom-type="edn" pub-id-type="custom">QSXMJC</article-id><article-id custom-type="elpub" pub-id-type="custom">prmed-153</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>МЕТОДИЧЕСКИЕ РЕКОМЕНДАЦИИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>GUIDELINES</subject></subj-group></article-categories><title-group><article-title>Скрининг рака предстательной железы в рамках диспансеризации определенных групп взрослого населения. Методические рекомендации</article-title><trans-title-group xml:lang="en"><trans-title>Prostate cancer screening of specific adult population groups. Guidelines</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4453-8430</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Драпкина</surname><given-names>О. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Drapkina</surname><given-names>O. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Драпкина Оксана Михайловна (Oksana M. Drapkina) — д.м.н., профессор, академик РАН, директор; главный внештатный специалист по терапии и общей врачебной практике Минздрава России; зав. кафедрой терапии и профилактической медицины</p><p>Петроверигский пер., 10, стр. 3, Москва, 101990</p></bio><bio xml:lang="en"><p>Petroverigsky Lane, 10, bld. 3, Moscow, 101990</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8784-8415</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Каприн</surname><given-names>А. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Kaprin</surname><given-names>A. D.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Каприн Андрей Дмитриевич (Andrey D. Kaprin) — д.м.н., профессор, академик РАН, генеральный директор, главный внештатный специалист-онколог (Центрального, Приволжского, Северо-Кавказского федерального округа, Донецкой Народной Республики, Луганской Народной Республики) Минздрава России, президент Ассоциации онкологов России, вице-президент РОПНИЗ по направлению "Онкопрофилактика"</p><p>2-й Боткинский проезд, д. 3, Москва /ул. Королева, д. 4, Обнинск, 249031</p></bio><bio xml:lang="en"><p>2nd Botkinsky proezd, 3, Moscow/ Koroleva str., 4, Obninsk, 249031</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7689-6032</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Иванов</surname><given-names>С. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Ivanov</surname><given-names>S. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Иванов Сергей Анатольевич (Sergey A. Ivanov) — д.м.н., профессор, чл.-корр. РАН, директор МРНЦ им. А. Ф. Цыба — филиала, главный внештатный специалист-онколог Минздрава России по ЦФО</p><p>2-й Боткинский проезд, д. 3, Москва /ул. Королева, д. 4, Обнинск, 249031</p></bio><bio xml:lang="en"><p>2nd Botkinsky proezd, 3, Moscow/ Koroleva str., 4, Obninsk, 249031</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4529-3308</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дроздова</surname><given-names>Л. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Drozdova</surname><given-names>L. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Дроздова Любовь Юрьевна (Liubov Yu. Drozdova) — к.м.н., руководитель отдела стратегического планирования и внедрения профилактических технологий, главный внештатный специалист по медицинской профилактике Минздрава России</p><p>Петроверигский пер., 10, стр. 3, Москва, 101990</p></bio><bio xml:lang="en"><p>Petroverigsky Lane, 10, bld. 3, Moscow, 101990</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3398-4128</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Алексеев</surname><given-names>Б. Я.</given-names></name><name name-style="western" xml:lang="en"><surname>Alekseev</surname><given-names>B. Ya.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Алексеев Борис Яковлевич (Boris Ya. Alekseev) — д.м.н., профессор, зам. генерального директора</p><p>2-й Боткинский проезд, д. 3, Москва /ул. Королева, д. 4, Обнинск, 249031</p></bio><bio xml:lang="en"><p>2nd Botkinsky proezd, 3, Moscow/ Koroleva str., 4, Obninsk, 249031</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8984-9056</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шепель</surname><given-names>Р. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Shepel</surname><given-names>R. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Шепель Руслан Николаевич (Ruslan N. Shepel) — к.м.н., зам. директора по перспективному развитию медицинской деятельности, руководитель отдела научно-стратегического развития первичной медико-санитарной помощи, в.н.с. отдела научно-стратегического развития первичной медико-санитарной помощи; доцент кафедры терапии и профилактической медицины ФГБОУ ВО "Российский университет медицины" Минздрава России; доцент кафедры общественного здоровья и организации здравоохранения</p><p>Петроверигский пер., 10, стр. 3, Москва, 101990</p></bio><bio xml:lang="en"><p>Petroverigsky Lane, 10, bld. 3, Moscow, 101990</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3258-0954</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Хайлова</surname><given-names>Ж. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Khailova</surname><given-names>Zh. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Хайлова Жанна Владимировна (Zhanna V. Khailova) — к.м.н., зам. директора по организационно-методической работе МРНЦ им. А. Ф. Цыба — филиала, доцент кафедры организации здравоохранения и общественного здоровья с курсом оценки технологий здравоохранения, президент Ассоциации онкологов и онкологических учреждений Центрального федерального округа</p><p>2-й Боткинский проезд, д. 3, Москва /ул. Королева, д. 4, Обнинск, 249031</p></bio><bio xml:lang="en"><p>2nd Botkinsky proezd, 3, Moscow/ Koroleva str., 4, Obninsk, 249031</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5597-9533</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Воробьев</surname><given-names>Н. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Vorobiev</surname><given-names>N. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Воробьев Николай Владимирович (Nikolay V. Vorobiev) — к.м.н., зам. директора по хирургии Московского научно-исследовательского онкологического института им. П. А. Герцена — филиала; уролог, доцент кафедры онкологии</p><p>2-й Боткинский проезд, д. 3, Москва /ул. Королева, д. 4, Обнинск, 249031</p></bio><bio xml:lang="en"><p>2nd Botkinsky proezd, 3, Moscow/ Koroleva str., 4, Obninsk, 249031</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6330-5264</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Алмазова</surname><given-names>И. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Almazova</surname><given-names>I. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Алмазова Ильда Исмаиловна (Ilda I. Almazova) — к.м.н., доцент, доцент кафедры терапии, общей врачебной практики с курсом гастроэнтерологии</p><p>Петроверигский пер., 10, стр. 3, Москва, 101990</p></bio><bio xml:lang="en"><p>Petroverigsky Lane, 10, bld. 3, Moscow, 101990</p></bio><email xlink:type="simple">IAlmazova@gnicpm.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8378-4338</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Рубцова</surname><given-names>Н. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Rubtsova</surname><given-names>N. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Рубцова Наталья Алефтиновна (Natalia A. Rubtsova) — д.м.н., зав. отделом лучевой диагностики Московского научно-исследовательского онкологического института им. П. А. Герцена — филиала</p><p>2-й Боткинский проезд, д. 3, Москва /ул. Королева, д. 4, Обнинск, 249031</p></bio><bio xml:lang="en"><p>2nd Botkinsky proezd, 3, Moscow/ Koroleva str., 4, Obninsk, 249031</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7406-9973</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сергеева</surname><given-names>Н. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Sergeeva</surname><given-names>N. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Сергеева Наталья Сергеевна (Natalia S. Sergeeva) — д.б.н., профессор, руководитель отделения "Прогноза эффективности консервативного лечения" МНИОИ им. П. А. Герцена — филиала, Заслуженный деятель науки Российской Федерации</p><p>2-й Боткинский проезд, д. 3, Москва /ул. Королева, д. 4, Обнинск, 249031</p></bio><bio xml:lang="en"><p>2nd Botkinsky proezd, 3, Moscow/ Koroleva str., 4, Obninsk, 249031</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2997-4936</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Маршутина</surname><given-names>Н. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Marshutina</surname><given-names>N. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Маршутина Нина Викторовна (Nina V. Marshutina) — к.б.н., н.с. отделения "Прогноза эффективности консервативного лечения" МНИОИ им. П. А. Герцена — филиала</p><p>2-й Боткинский проезд, д. 3, Москва /ул. Королева, д. 4, Обнинск, 249031</p></bio><bio xml:lang="en"><p>2nd Botkinsky proezd, 3, Moscow/ Koroleva str., 4, Obninsk, 249031</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3870-6522</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Митькова</surname><given-names>М. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Mitkova</surname><given-names>M. D.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Митькова Мина Даутовна (Mina D. Mitkova) — к.м.н., доцент, доцент кафедры ультразвуковой диагностики</p><p>Баррикадная ул., д. 2/1 стр. 1, Москва, 125993</p></bio><bio xml:lang="en"><p>Barrikadnaya str., 2/1, Building 1, Moscow, 125993</p></bio><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9854-7375</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Крашенинников</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Krasheninnikov</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Крашенинников Алексей Артурович (Alexey A. Krasheninnikov) — к.м.н., врач-онколог, зав. урологическим отделением с химиотерапией Московского научно-исследовательского онкологического института им. П. А. Герцена — филиал</p><p>2-й Боткинский проезд, д. 3, Москва /ул. Королева, д. 4, Обнинск, 249031</p></bio><bio xml:lang="en"><p>2nd Botkinsky proezd, 3, Moscow/ Koroleva str., 4, Obninsk, 249031</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1826-1332</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Абдрахманов</surname><given-names>Р. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Abdrakhmanov</surname><given-names>R. R.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Абдрахманов Рустем Рамильевич (Rustem R. Abdrakhmanov) — руководитель Центра организации программ скрининга онкологических заболеваний</p><p>Петроверигский пер., 10, стр. 3, Москва, 101990</p></bio><bio xml:lang="en"><p>Petroverigsky Lane, 10, bld. 3, Moscow, 101990</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3763-7454</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Щекин</surname><given-names>В. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Shchekin</surname><given-names>V. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Щекин Владимир Иванович (Vladimir I. Shchekin) — к.м.н., врач-ординатор урологического отделения с химиотерапией Московского научно-исследовательского онкологического института им. П. А. Герцена — филиал</p><p>2-й Боткинский проезд, д. 3, Москва /ул. Королева, д. 4, Обнинск, 249031</p></bio><bio xml:lang="en"><p>2nd Botkinsky proezd, 3, Moscow/ Koroleva str., 4, Obninsk, 249031</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0005-0366-5555</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Созыкин</surname><given-names>М. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Sozykin</surname><given-names>M. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Созыкин Михаил Алексеевич (Michail A. Sozykin) — врач-онколог урологического отделения с химиотерапией Московского научно-исследовательского онкологического института им. П. А. Герцена — филиал</p><p>2-й Боткинский проезд, д. 3, Москва /ул. Королева, д. 4, Обнинск, 249031</p></bio><bio xml:lang="en"><p>2nd Botkinsky proezd, 3, Moscow/ Koroleva str., 4, Obninsk, 249031</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7108-522X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Долгачёва</surname><given-names>Д. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Dolgacheva</surname><given-names>D. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Долгачёва Дарья Вячеславовна (Darya V. Dolgacheva) — к.м.н., врач отделения ультразвуковой диагностики и интервенционных технологий МНИОИ им. П. А. Герцена — филиала</p><p>2-й Боткинский проезд, д. 3, Москва /ул. Королева, д. 4, Обнинск, 249031</p></bio><bio xml:lang="en"><p>2nd Botkinsky proezd, 3, Moscow/ Koroleva str., 4, Obninsk, 249031</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5379-7170</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Иванова</surname><given-names>Е. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Ivanova</surname><given-names>E. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Иванова Екатерина Сергеевна (Ekaterina S. Ivanova) — к.м.н., руководитель отдела координации профилактики и укрепления общественного здоровья в регионах, руководитель Федерального Центра здоровья, главный специалист по медицинской профилактике Минздрава России по ЦФО</p><p>Петроверигский пер., 10, стр. 3, Москва, 101990</p></bio><bio xml:lang="en"><p>Petroverigsky Lane, 10, bld. 3, Moscow, 101990</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8627-6160</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Егоров</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Egorov</surname><given-names>V. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Егоров Вадим Анатольевич (Vadim A. Egorov) — к.м.н., в.н.с. отдела стратегического планирования и внедрения профилактических технологий</p><p>Петроверигский пер., 10, стр. 3, Москва, 101990</p></bio><bio xml:lang="en"><p>Petroverigsky Lane, 10, bld. 3, Moscow, 101990</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1002-1895</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бернс</surname><given-names>С. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Berns</surname><given-names>S. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Бернс Светлана Александровна (Svetlana A. Berns) — д.м.н., профессор, заведующая кафедрой терапии, общей врачебной практики с курсом гастроэнтерологии, руководитель отдела изучения патогенетических аспектов старения</p><p>Петроверигский пер., 10, стр. 3, Москва, 101990</p></bio><bio xml:lang="en"><p>Petroverigsky Lane, 10, bld. 3, Moscow, 101990</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8804-2237</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Степанов</surname><given-names>С. О.</given-names></name><name name-style="western" xml:lang="en"><surname>Stepanov</surname><given-names>S. O.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Степанов Станислав Олегович (Stanislav O. Stepanov) — д.м.н., руководитель отделения ультразвуковой диагностики и интервенционных технологий МНИОИ им. П. А. Герцена — филиала</p><p>2-й Боткинский проезд, д. 3, Москва /ул. Королева, д. 4, Обнинск, 249031</p></bio><bio xml:lang="en"><p>2nd Botkinsky proezd, 3, Moscow/ Koroleva str., 4, Obninsk, 249031</p></bio><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУ "Национальный медицинский исследовательский центр терапии и профилактической медицины" Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>National Medical Research Center for Therapy and Preventive Medicine</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБУ "Национальный медицинский исследовательский центр радиологии" Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>National Medical Research Radiological Centre</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>ФГБОУ ДПО "Российская медицинская академия непрерывного профессионального образования" Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Russian Medical Academy of Continuous Professional Education</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2026</year></pub-date><pub-date pub-type="epub"><day>16</day><month>07</month><year>2026</year></pub-date><volume>3</volume><issue>2S</issue><issue-title>Рекомендации по диспансерному наблюдению</issue-title><fpage>295</fpage><lpage>329</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Драпкина О.М., Каприн А.Д., Иванов С.А., Дроздова Л.Ю., Алексеев Б.Я., Шепель Р.Н., Хайлова Ж.В., Воробьев Н.В., Алмазова И.И., Рубцова Н.А., Сергеева Н.С., Маршутина Н.В., Митькова М.Д., Крашенинников А.А., Абдрахманов Р.Р., Щекин В.И., Созыкин М.А., Долгачёва Д.В., Иванова Е.С., Егоров В.А., Бернс С.А., Степанов С.О., 2026</copyright-statement><copyright-year>2026</copyright-year><copyright-holder xml:lang="ru">Драпкина О.М., Каприн А.Д., Иванов С.А., Дроздова Л.Ю., Алексеев Б.Я., Шепель Р.Н., Хайлова Ж.В., Воробьев Н.В., Алмазова И.И., Рубцова Н.А., Сергеева Н.С., Маршутина Н.В., Митькова М.Д., Крашенинников А.А., Абдрахманов Р.Р., Щекин В.И., Созыкин М.А., Долгачёва Д.В., Иванова Е.С., Егоров В.А., Бернс С.А., Степанов С.О.</copyright-holder><copyright-holder xml:lang="en">Drapkina O.M., Kaprin A.D., Ivanov S.A., Drozdova L.Y., Alekseev B.Y., Shepel R.N., Khailova Z.V., Vorobiev N.V., Almazova I.I., Rubtsova N.A., Sergeeva N.S., Marshutina N.V., Mitkova M.D., Krasheninnikov A.A., Abdrakhmanov R.R., Shchekin V.I., Sozykin M.A., Dolgacheva D.V., Ivanova E.S., Egorov V.A., Berns S.A., Stepanov S.O.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://prmed.elpub.ru/jour/article/view/153">https://prmed.elpub.ru/jour/article/view/153</self-uri><abstract><p>Методические рекомендации содержат информацию о теоретических основах скрининга рака предстательной железы, нормативно-правовых актах, регламентирующих организацию мероприятий скрининга рака предстательной железы в рамках диспансеризации определенных групп взрослого населения, особенностях интерпретации результатов лабораторных и инструментальных методов исследования при скрининге рака предстательной железы, алгоритмах маршрутизации пациентов.</p><p>Методические рекомендации разработаны для руководителей медицинских организаций, оказывающих первичную медико-санитарную помощь в части организации процессов, врачей-терапевтов, врачей общей практики, врачей-урологов, специалистов со средним медицинским образованием, которые непосредственно участвуют в реализации процесса диспансеризации определенных групп взрослого населения.</p></abstract><trans-abstract xml:lang="en"><p>These guidelines contain information on the theoretical foundations of prostate cancer screening, regulatory acts governing the management of prostate cancer screening of specific adult population groups, the specifics of interpreting the results of laboratory and imaging examinations during prostate cancer screening, and patient routing algorithms.</p><p>These guidelines have been developed for the heads of health facilities providing primary healthcare, including primary care physicians, general practitioners, urologists, and specialists with secondary medical education who are directly involved in outpatient screening of specific adult population groups.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>рак предстательной железы</kwd><kwd>методические рекомендации</kwd><kwd>диспансерное наблюдение</kwd><kwd>взрослые</kwd></kwd-group><kwd-group xml:lang="en"><kwd>prostate cancer</kwd><kwd>guidelines</kwd><kwd>follow-up monitoring</kwd><kwd>adults</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Cornford P, van den Bergh RCN, Briers E, et al.. EAU-EANM-ESTRO-ESUR-ISUPSIOG Guidelines on Prostate Cancer-2024 Update. Part I: Screening, Diagnosis, and Local Treatment with Curative Intent. Eur Urol. 2024;86(2):148-63. doi:10.1016/j.eururo.2024.03.027.</mixed-citation><mixed-citation xml:lang="en">Cornford P, van den Bergh RCN, Briers E, et al.. EAU-EANM-ESTRO-ESUR-ISUPSIOG Guidelines on Prostate Cancer-2024 Update. Part I: Screening, Diagnosis, and Local Treatment with Curative Intent. Eur Urol. 2024;86(2):148-63. doi:10.1016/j.eururo.2024.03.027.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Culp MB, Soerjomataram I, Efstathiou JA, et al. Recent Global Patterns in Prostate Cancer Incidence and Mortality Rates. Eur Urol. 2020;77(1):38-52. doi:10.1016/j.eururo.2019.08.005.</mixed-citation><mixed-citation xml:lang="en">Culp MB, Soerjomataram I, Efstathiou JA, et al. Recent Global Patterns in Prostate Cancer Incidence and Mortality Rates. Eur Urol. 2020;77(1):38-52. doi:10.1016/j.eururo.2019.08.005.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Bray F, Laversanne M, Sung H, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2024;74(3):229-63. doi:10.3322/caac.21834.</mixed-citation><mixed-citation xml:lang="en">Bray F, Laversanne M, Sung H, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2024;74(3):229-63. doi:10.3322/caac.21834.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Haas GP, Delongchamps N, Brawley OW, et al. The worldwide epidemiology of prostate cancer: perspectives from autopsy studies. Can J Urol. 2008;15(1):3866-71.</mixed-citation><mixed-citation xml:lang="en">Haas GP, Delongchamps N, Brawley OW, et al. The worldwide epidemiology of prostate cancer: perspectives from autopsy studies. Can J Urol. 2008;15(1):3866-71.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Bell KJ, Del Mar C, Wright G, et al. Prevalence of incidental prostate cancer: A systematic review of autopsy studies. Int J Cancer. 2015;137(7):1749-57. doi:10.1002/ijc.29538.</mixed-citation><mixed-citation xml:lang="en">Bell KJ, Del Mar C, Wright G, et al. Prevalence of incidental prostate cancer: A systematic review of autopsy studies. Int J Cancer. 2015;137(7):1749-57. doi:10.1002/ijc.29538.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Fleshner K, Carlsson SV, Roobol MJ. The effect of the USPSTF PSA screening recommendation on prostate cancer incidence patterns in the USA. Nat Rev Urol. 2017;14(1):26-37. doi:10.1038/nrurol.2016.251.</mixed-citation><mixed-citation xml:lang="en">Fleshner K, Carlsson SV, Roobol MJ. The effect of the USPSTF PSA screening recommendation on prostate cancer incidence patterns in the USA. Nat Rev Urol. 2017;14(1):26-37. doi:10.1038/nrurol.2016.251.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Kimura T, Sato S, Takahashi H, Egawa S.Global Trends of Latent Prostate Cancer in Autopsy Studies. Cancers (Basel). 2021;13(2):359. doi:10.3390/cancers13020359.</mixed-citation><mixed-citation xml:lang="en">Kimura T, Sato S, Takahashi H, Egawa S.Global Trends of Latent Prostate Cancer in Autopsy Studies. Cancers (Basel). 2021;13(2):359. doi:10.3390/cancers13020359.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">James ND, Tannock I, N'Dow J, et al. The Lancet Commission on prostate cancer: planning for the surge in cases. Lancet. 2024;403(10437):1683-722. doi:10.1016/S0140-6736(24)00651-2. Erratum in: Lancet. 2024;403(10437):1634. doi:10.1016/S0140-6736(24)00748-7.</mixed-citation><mixed-citation xml:lang="en">James ND, Tannock I, N'Dow J, et al. The Lancet Commission on prostate cancer: planning for the surge in cases. Lancet. 2024;403(10437):1683-722. doi:10.1016/S0140-6736(24)00651-2. Erratum in: Lancet. 2024;403(10437):1634. doi:10.1016/S0140-6736(24)00748-7.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Злокачественные новообразования в России в 2023 году (заболеваемость и смертность). Под ред. А.Д. Каприна и др. М.: МНИОИ им. П.А. Герцена — филиал ФГБУ "НМИЦ радиологии" Минздрава России, 2024. илл. 276 с.; ISBN: 978-5-85502-298-8.</mixed-citation><mixed-citation xml:lang="en">Malignant neoplasms in Russia in 2023 (morbidity and mortality). Edited by A.D. Kaprin, et al. Moscow: P.A. Herzen Moscow State Medical Research Institute — branch of the Federal State Budgetary Institution "NMITS of Radiology" of the Ministry of Health of the Russian Federation, 2024. 276 p. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Состояние онкологической помощи населению России в 2024 году. Под ред. А.Д. Каприна и др. М.: МНИОИ им. П.А. Герцена — филиал ФГБУ "НМИЦ радиологии" Минздрава России, 2025. илл. 275 с.; ISBN: 978-5-85502-309-1.</mixed-citation><mixed-citation xml:lang="en">The state of oncological care for the Russian population in 2024. Edited by A.D. Kaprin et al. Moscow: P.A. Herzen Moscow Institute of Medical Sciences — branch of the Federal State Budgetary Institution "NMITS of Radiology" of the Ministry of Health of the Russian Federation, 2025. 275 p. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Wilson JM, Jungner YG. Principios y metodos del examen colectivo para identificar enfermedades [Principles and practice of mass screening for disease]. Bol Oficina Sanit Panam. 1968;65(4):281-393. Spanish.</mixed-citation><mixed-citation xml:lang="en">Wilson JM, Jungner YG. Principios y metodos del examen colectivo para identificar enfermedades [Principles and practice of mass screening for disease]. Bol Oficina Sanit Panam. 1968;65(4):281-393. Spanish.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Drapkina O.М., Samorodskaya I.V. Screening: terminology, principles and international experience. Preventive medicine. 2019;22(1):90-7. (In Russ.) Драпкина О.М., Самородская И.В. Скрининг: терминология, принципы и международный опыт. Профилактическая медицина. 2019;22(1):90-7. doi:10.17116/profmed20192201190.</mixed-citation><mixed-citation xml:lang="en">Drapkina O.М., Samorodskaya I.V. Screening: terminology, principles and international experience. Preventive medicine. 2019;22(1):90-7. (In Russ.) Драпкина О.М., Самородская И.В. Скрининг: терминология, принципы и международный опыт. Профилактическая медицина. 2019;22(1):90-7. doi:10.17116/profmed20192201190.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Martin RM, Turner EL, Young GJ, et al.; CAP Trial Group. Prostate-Specific Antigen Screening and 15-Year Prostate Cancer Mortality: A Secondary Analysis of the CAP Randomized Clinical Trial. JAMA. 2024;331(17):1460-70. doi:10.1001/jama.2024.4011.</mixed-citation><mixed-citation xml:lang="en">Martin RM, Turner EL, Young GJ, et al.; CAP Trial Group. Prostate-Specific Antigen Screening and 15-Year Prostate Cancer Mortality: A Secondary Analysis of the CAP Randomized Clinical Trial. JAMA. 2024;331(17):1460-70. doi:10.1001/jama.2024.4011.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">De Vrieze M, Hübner A, Al-Monajjed R, et al. Das Prostatakarzinom-Screening — aktueller Überblick [Prostate cancer screening-current overview]. Radiologie (Heidelb). 2024;64(6):479-87. German. doi:10.1007/s00117-024-01312-1. Erratum in: Radiologie (Heidelb). 2024;64(7):545. doi:10.1007/s00117-024-01329-6.</mixed-citation><mixed-citation xml:lang="en">De Vrieze M, Hübner A, Al-Monajjed R, et al. Das Prostatakarzinom-Screening — aktueller Überblick [Prostate cancer screening-current overview]. Radiologie (Heidelb). 2024;64(6):479-87. German. doi:10.1007/s00117-024-01312-1. Erratum in: Radiologie (Heidelb). 2024;64(7):545. doi:10.1007/s00117-024-01329-6.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Hugosson J, Roobol MJ, Månsson M, et al.; ERSPC investigators. A 16-yr Followup of the European Randomized study of Screening for Prostate Cancer. Eur Urol. 2019;76(1):43-51. doi:10.1016/j.eururo.2019.02.009.</mixed-citation><mixed-citation xml:lang="en">Hugosson J, Roobol MJ, Månsson M, et al.; ERSPC investigators. A 16-yr Followup of the European Randomized study of Screening for Prostate Cancer. Eur Urol. 2019;76(1):43-51. doi:10.1016/j.eururo.2019.02.009.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Loeb S, Gonzalez CM, Roehl KA, et al. Pathological characteristics of prostate cancer detected through prostate specific antigen based screening. J Urol. 2006;175(3 Pt 1):902-6. doi:10.1016/S0022-5347(05)00327-7.</mixed-citation><mixed-citation xml:lang="en">Loeb S, Gonzalez CM, Roehl KA, et al. Pathological characteristics of prostate cancer detected through prostate specific antigen based screening. J Urol. 2006;175(3 Pt 1):902-6. doi:10.1016/S0022-5347(05)00327-7.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Heijnsdijk EA, Wever EM, Auvinen A, et al. Quality-of-life effects of prostatespecific antigen screening. N Engl J Med. 2012;367(7):595-605. doi:10.1056/NEJMoa1201637.</mixed-citation><mixed-citation xml:lang="en">Heijnsdijk EA, Wever EM, Auvinen A, et al. Quality-of-life effects of prostatespecific antigen screening. N Engl J Med. 2012;367(7):595-605. doi:10.1056/NEJMoa1201637.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Ilic D, Djulbegovic M, Jung JH, et al. Prostate cancer screening with prostatespecific antigen (PSA) test: a systematic review and meta-analysis. BMJ. 2018;362:k3519. doi:10.1136/bmj.k3519.</mixed-citation><mixed-citation xml:lang="en">Ilic D, Djulbegovic M, Jung JH, et al. Prostate cancer screening with prostatespecific antigen (PSA) test: a systematic review and meta-analysis. BMJ. 2018;362:k3519. doi:10.1136/bmj.k3519.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Schröder FH, Roobol MJ. ERSPC and PLCO prostate cancer screening studies: what are the differences? Eur Urol. 2010;58(1):46-52. doi:10.1016/j.eururo.2010.03.033.</mixed-citation><mixed-citation xml:lang="en">Schröder FH, Roobol MJ. ERSPC and PLCO prostate cancer screening studies: what are the differences? Eur Urol. 2010;58(1):46-52. doi:10.1016/j.eururo.2010.03.033.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Hugosson J, Godtman RA, Carlsson SV, et al. Eighteen-year follow-up of the Göteborg Randomized Population-based Prostate Cancer Screening Trial: effect of sociodemographic variables on participation, prostate cancer incidence and mortality. Scand J Urol. 2018;52(1):27-37. doi:10.1080/21681805.2017.1411392.</mixed-citation><mixed-citation xml:lang="en">Hugosson J, Godtman RA, Carlsson SV, et al. Eighteen-year follow-up of the Göteborg Randomized Population-based Prostate Cancer Screening Trial: effect of sociodemographic variables on participation, prostate cancer incidence and mortality. Scand J Urol. 2018;52(1):27-37. doi:10.1080/21681805.2017.1411392.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Frånlund M, Månsson M, Godtman RA, et al. Results from 22 years of Followup in the Göteborg Randomized Population-Based Prostate Cancer Screening Trial. J Urol. 2022;208(2):292-300. doi:10.1097/JU.0000000000002696.</mixed-citation><mixed-citation xml:lang="en">Frånlund M, Månsson M, Godtman RA, et al. Results from 22 years of Followup in the Göteborg Randomized Population-Based Prostate Cancer Screening Trial. J Urol. 2022;208(2):292-300. doi:10.1097/JU.0000000000002696.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Ankerst DP, Hoefler J, Bock S, et al. Prostate Cancer Prevention Trial risk calculator 2.0 for the prediction of low- vs high-grade prostate cancer. Urology. 2014;83(6):1362-7. doi:10.1016/j.urology.2014.02.035.</mixed-citation><mixed-citation xml:lang="en">Ankerst DP, Hoefler J, Bock S, et al. Prostate Cancer Prevention Trial risk calculator 2.0 for the prediction of low- vs high-grade prostate cancer. Urology. 2014;83(6):1362-7. doi:10.1016/j.urology.2014.02.035.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Сергеева Н.С., Скачкова Т.Е., Маршутина Н.В. и др. Клиническая значимость ПСА-ассоциированных тестов в диагностике и стадировании рака предстательной железы. Онкология. Журнал им. П.А. Герцена. 2018;(1):55-63. doi:10.17116/onkolog20187155-67.</mixed-citation><mixed-citation xml:lang="en">Sergeeva NS, Skachkova TE, Marshutina NV, et al. The clinical significance of PSA-associated tests in the diagnosis and staging of prostate cancer. Oncology. P.A. Herzen Journal. 2018;(1):55-63. (In Russ.) doi:10.17116/onkolog20187155-67.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Bandala-Jacques A, Castellanos Esquivel KD, et al. Prostate Cancer Risk Calculators for Healthy Populations: Systematic Review. JMIR Cancer. 2021;7(3):e30430. doi:10.2196/30430.</mixed-citation><mixed-citation xml:lang="en">Bandala-Jacques A, Castellanos Esquivel KD, et al. Prostate Cancer Risk Calculators for Healthy Populations: Systematic Review. JMIR Cancer. 2021;7(3):e30430. doi:10.2196/30430.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Fazekas T, Shim SR, Basile G, Baboudjian M, et al. Magnetic Resonance Imaging in Prostate Cancer Screening: A Systematic Review and Meta-Analysis. JAMA Oncol. 2024;10(6):745-54. doi:10.1001/jamaoncol.2024.0734.</mixed-citation><mixed-citation xml:lang="en">Fazekas T, Shim SR, Basile G, Baboudjian M, et al. Magnetic Resonance Imaging in Prostate Cancer Screening: A Systematic Review and Meta-Analysis. JAMA Oncol. 2024;10(6):745-54. doi:10.1001/jamaoncol.2024.0734.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Kasivisvanathan V, Rannikko AS, Borghi M, et al.; PRECISION Study Group Collaborators. MRI-Targeted or Standard Biopsy for Prostate-Cancer Diagnosis. N Engl J Med. 2018;378(19):1767-77. doi:10.1056/NEJMoa1801993.</mixed-citation><mixed-citation xml:lang="en">Kasivisvanathan V, Rannikko AS, Borghi M, et al.; PRECISION Study Group Collaborators. MRI-Targeted or Standard Biopsy for Prostate-Cancer Diagnosis. N Engl J Med. 2018;378(19):1767-77. doi:10.1056/NEJMoa1801993.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Nordström T, Discacciati A, Bergman M, et al.; STHLM3 study group. Prostate cancer screening using a combination of risk-prediction, MRI, and targeted prostate biopsies (STHLM3-MRI): a prospective, population-based, randomised, open-label, non-inferiority trial. Lancet Oncol. 2021;22(9):1240-9. doi:10.1016/S1470-2045(21)00348-X.</mixed-citation><mixed-citation xml:lang="en">Nordström T, Discacciati A, Bergman M, et al.; STHLM3 study group. Prostate cancer screening using a combination of risk-prediction, MRI, and targeted prostate biopsies (STHLM3-MRI): a prospective, population-based, randomised, open-label, non-inferiority trial. Lancet Oncol. 2021;22(9):1240-9. doi:10.1016/S1470-2045(21)00348-X.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Ahn H, Park MY, Shin JI, et al. Fast Biparametric Versus Multiparametric Magnetic Resonance Imaging for Triage of Men with Elevated Prostate-specific Antigen: The PRO-TRIAGE Prospective Comparative Trial. Eur Urol Oncol. 2026;9(2):320-7. doi:10.1016/j.euo.2025.07.001.</mixed-citation><mixed-citation xml:lang="en">Ahn H, Park MY, Shin JI, et al. Fast Biparametric Versus Multiparametric Magnetic Resonance Imaging for Triage of Men with Elevated Prostate-specific Antigen: The PRO-TRIAGE Prospective Comparative Trial. Eur Urol Oncol. 2026;9(2):320-7. doi:10.1016/j.euo.2025.07.001.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">US Preventive Services Task Force; Grossman DC, Curry SJ, Owens DK, et al. Screening for Prostate Cancer: US Preventive Services Task Force Recommendation Statement. JAMA. 2018;319(18):1901-13. doi:10.1001/jama.2018.3710. Erratum in: JAMA. 2018;319(23):2443. doi:10.1001/jama.2018.7453.</mixed-citation><mixed-citation xml:lang="en">US Preventive Services Task Force; Grossman DC, Curry SJ, Owens DK, et al. Screening for Prostate Cancer: US Preventive Services Task Force Recommendation Statement. JAMA. 2018;319(18):1901-13. doi:10.1001/jama.2018.3710. Erratum in: JAMA. 2018;319(23):2443. doi:10.1001/jama.2018.7453.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Steinberg G.D., Carter B. S., Beaty T.H. et al. Family history and the risk of prostate cancer. Prostate 1990;17:337-437.</mixed-citation><mixed-citation xml:lang="en">Steinberg G.D., Carter B. S., Beaty T.H. et al. Family history and the risk of prostate cancer. Prostate 1990;17:337-437.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Stewart RW, Lizama S, Peairs K, et al. Screening for prostate cancer. Semin Oncol. 2017;44(1):47-56. doi:10.1053/j.seminoncol.2017.02.001.</mixed-citation><mixed-citation xml:lang="en">Stewart RW, Lizama S, Peairs K, et al. Screening for prostate cancer. Semin Oncol. 2017;44(1):47-56. doi:10.1053/j.seminoncol.2017.02.001.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Hemminki K.Familial risk and familial survival in prostate cancer. World J Urol. 2012;30(2):143-8. doi:10.1007/s00345-011-0801-1.</mixed-citation><mixed-citation xml:lang="en">Hemminki K.Familial risk and familial survival in prostate cancer. World J Urol. 2012;30(2):143-8. doi:10.1007/s00345-011-0801-1.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Randazzo M, Müller A, Carlsson S, et al. A positive family history as a risk factor for prostate cancer in a population-based study with organised prostate-specific antigen screening: results of the Swiss European Randomised Study of Screening for Prostate Cancer (ERSPC, Aarau). BJU Int. 2016;117(4):576-83. doi:10.1111/bju.13310.</mixed-citation><mixed-citation xml:lang="en">Randazzo M, Müller A, Carlsson S, et al. A positive family history as a risk factor for prostate cancer in a population-based study with organised prostate-specific antigen screening: results of the Swiss European Randomised Study of Screening for Prostate Cancer (ERSPC, Aarau). BJU Int. 2016;117(4):576-83. doi:10.1111/bju.13310.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Kensler KH, Johnson R, Morley F, et al. Prostate cancer screening in African American men: a review of the evidence. J Natl Cancer Inst. 2024;116(1):34-52. doi:10.1093/jnci/djad193.</mixed-citation><mixed-citation xml:lang="en">Kensler KH, Johnson R, Morley F, et al. Prostate cancer screening in African American men: a review of the evidence. J Natl Cancer Inst. 2024;116(1):34-52. doi:10.1093/jnci/djad193.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Page EC, Bancroft EK, Brook MN, et al. Interim Results from the IMPACT Study: Evidence for Prostate-specific Antigen Screening in BRCA2 Mutation Carriers. Eur Urol. 2019;76(6):831-42. doi:10.1016/j.eururo.2019.08.019.</mixed-citation><mixed-citation xml:lang="en">Page EC, Bancroft EK, Brook MN, et al. Interim Results from the IMPACT Study: Evidence for Prostate-specific Antigen Screening in BRCA2 Mutation Carriers. Eur Urol. 2019;76(6):831-42. doi:10.1016/j.eururo.2019.08.019.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Bancroft EK, Page EC, Castro E, et al.; IMPACT Collaborators. Targeted prostate cancer screening in BRCA1 and BRCA2 mutation carriers: results from the initial screening round of the IMPACT study. Eur Urol. 2014;66(3):489-99. doi:10.1016/j.eururo.2014.01.003. Erratum in: Eur Urol. 2015;67(6):e126. doi:10.1016/j.eururo.2014.12.001.</mixed-citation><mixed-citation xml:lang="en">Bancroft EK, Page EC, Castro E, et al.; IMPACT Collaborators. Targeted prostate cancer screening in BRCA1 and BRCA2 mutation carriers: results from the initial screening round of the IMPACT study. Eur Urol. 2014;66(3):489-99. doi:10.1016/j.eururo.2014.01.003. Erratum in: Eur Urol. 2015;67(6):e126. doi:10.1016/j.eururo.2014.12.001.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Pritchard CC, Mateo J, Walsh MF, et al. Inherited DNA-Repair Gene Mutations in Men with Metastatic Prostate Cancer. N Engl J Med. 2016;375(5):443-53. doi:10.1056/NEJMoa1603144.</mixed-citation><mixed-citation xml:lang="en">Pritchard CC, Mateo J, Walsh MF, et al. Inherited DNA-Repair Gene Mutations in Men with Metastatic Prostate Cancer. N Engl J Med. 2016;375(5):443-53. doi:10.1056/NEJMoa1603144.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Nicolosi P, Ledet E, Yang S, et al. Prevalence of Germline Variants in Prostate Cancer and Implications for Current Genetic Testing Guidelines. JAMA Oncol. 2019;5(4):523-8.</mixed-citation><mixed-citation xml:lang="en">Nicolosi P, Ledet E, Yang S, et al. Prevalence of Germline Variants in Prostate Cancer and Implications for Current Genetic Testing Guidelines. JAMA Oncol. 2019;5(4):523-8.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Lowenstein LM, et al. Active surveillance for prostate and thyroid cancers: evolution in clinical paradigms and lessons learned. Nat Rev Clin Oncol. 2019 Mar;16(3):168-84. doi:10.1038/s41571-018-0116-x.</mixed-citation><mixed-citation xml:lang="en">Lowenstein LM, et al. Active surveillance for prostate and thyroid cancers: evolution in clinical paradigms and lessons learned. Nat Rev Clin Oncol. 2019 Mar;16(3):168-84. doi:10.1038/s41571-018-0116-x.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Wang MC, Valenzuela LA, Murphy GP, Chu TM. Purification of a human prostate specific antigen. Invest Urol. 1979;17(2):159-63.</mixed-citation><mixed-citation xml:lang="en">Wang MC, Valenzuela LA, Murphy GP, Chu TM. Purification of a human prostate specific antigen. Invest Urol. 1979;17(2):159-63.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Hara M, Koyanagi Y, Inoue T, Fukuyama T. [Some physico-chemical characteristics of " -seminoprotein", an antigenic component specific for human seminal plasma. Forensic immunological study of body fluids and secretion. VII]. Nihon Hoigaku Zasshi. 1971 25(4):322-4. Japanese.</mixed-citation><mixed-citation xml:lang="en">Hara M, Koyanagi Y, Inoue T, Fukuyama T. [Some physico-chemical characteristics of " -seminoprotein", an antigenic component specific for human seminal plasma. Forensic immunological study of body fluids and secretion. VII]. Nihon Hoigaku Zasshi. 1971 25(4):322-4. Japanese.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Hara M, Inoue T, Koyanagi Y, Gotoh J, Yamazaki H, Fukuyama T.Preparation and immunoelectrophoretic assessment of antisera to human seminal plasma. Nippon Hoigaku Zasshi. 1966;20:356. (Abstract in Japanese);</mixed-citation><mixed-citation xml:lang="en">Hara M, Inoue T, Koyanagi Y, Gotoh J, Yamazaki H, Fukuyama T.Preparation and immunoelectrophoretic assessment of antisera to human seminal plasma. Nippon Hoigaku Zasshi. 1966;20:356. (Abstract in Japanese);</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Ablin RJ, Bronson P, Soanes WA, Witebsky E. Tissue- and species-specific antigens of normal human prostatic tissue. J Immunol. 1970;104(6):1329-39.</mixed-citation><mixed-citation xml:lang="en">Ablin RJ, Bronson P, Soanes WA, Witebsky E. Tissue- and species-specific antigens of normal human prostatic tissue. J Immunol. 1970;104(6):1329-39.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Li TS, Beling CG. Isolation and characterization of two specific antigens of human seminal plasma. Fertil Steril. 1973;24(2):134-44. doi:10.1016/s0015-0282(16)39496-1.</mixed-citation><mixed-citation xml:lang="en">Li TS, Beling CG. Isolation and characterization of two specific antigens of human seminal plasma. Fertil Steril. 1973;24(2):134-44. doi:10.1016/s0015-0282(16)39496-1.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Catalona WJ. History of the discovery and clinical translation of prostate-specific antigen. Asian J Urol. 2014;1(1):12-4. doi:10.1016/j.ajur.2014.09.008.</mixed-citation><mixed-citation xml:lang="en">Catalona WJ. History of the discovery and clinical translation of prostate-specific antigen. Asian J Urol. 2014;1(1):12-4. doi:10.1016/j.ajur.2014.09.008.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Сatalona WJ, Smith DS, Ratliff TL, et al. Measurement of prostate-specific antigen in serum as a screening test for prostate cancer. N Engl J Med. 1991;324(17):1156-116;</mixed-citation><mixed-citation xml:lang="en">Сatalona WJ, Smith DS, Ratliff TL, et al. Measurement of prostate-specific antigen in serum as a screening test for prostate cancer. N Engl J Med. 1991;324(17):1156-116;</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Kouriefs C, Sahoyl M, Grange P, Muir G.Prostate specific antigen through the years. Arch Ital Urol Androl. 2009;81(4):195-8.</mixed-citation><mixed-citation xml:lang="en">Kouriefs C, Sahoyl M, Grange P, Muir G.Prostate specific antigen through the years. Arch Ital Urol Androl. 2009;81(4):195-8.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Stephan C, Rittenhouse H, Hu X, Cammann H, Jung K.Prostate-Specific Antigen (PSA) Screening and New Biomarkers for Prostate Cancer (PCa). EJIFCC. 2014;25(1):55-78.</mixed-citation><mixed-citation xml:lang="en">Stephan C, Rittenhouse H, Hu X, Cammann H, Jung K.Prostate-Specific Antigen (PSA) Screening and New Biomarkers for Prostate Cancer (PCa). EJIFCC. 2014;25(1):55-78.</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Diamandis EP, Yu H. Nonprostatic sources of prostate-specific antigen. Urol Clin North Am. 1997;24(2):275-82.</mixed-citation><mixed-citation xml:lang="en">Diamandis EP, Yu H. Nonprostatic sources of prostate-specific antigen. Urol Clin North Am. 1997;24(2):275-82.</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Stamey TA, Yang N, Hay AR, et al. Prostate-specific antigen as a serum marker for adenocarcinoma of the prostate. N Engl J Med. 1987;317(15):909-16. doi:10.1056/NEJM198710083171501.</mixed-citation><mixed-citation xml:lang="en">Stamey TA, Yang N, Hay AR, et al. Prostate-specific antigen as a serum marker for adenocarcinoma of the prostate. N Engl J Med. 1987;317(15):909-16. doi:10.1056/NEJM198710083171501.</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Носов А.К. Раннее выявление рака предстательной железы. Практическая онкология. 2010;11(2):74-80.</mixed-citation><mixed-citation xml:lang="en">Nosov A.K. Early detection of prostate cancer. Practical oncology. 2010;11(2):74-80. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Andriole GL, Crawford ED, Grubb RL, et al. PLCO Project Team. Mortality results from a randomized prostate-cancer screening trial. N Engl J Med. 2009;360(13):1310-9. doi:10.1056/NEJMoa0810696.</mixed-citation><mixed-citation xml:lang="en">Andriole GL, Crawford ED, Grubb RL, et al. PLCO Project Team. Mortality results from a randomized prostate-cancer screening trial. N Engl J Med. 2009;360(13):1310-9. doi:10.1056/NEJMoa0810696.</mixed-citation></citation-alternatives></ref><ref id="cit53"><label>53</label><citation-alternatives><mixed-citation xml:lang="ru">Schröder FH, Hugosson J, Roobol MJ, et al. Screening and prostate cancer mortality: results of the European Randomised Study of Screening for Prostate Cancer (ERSPC) at 13 years of follow-up. Lancet. 2014;384(9959):2027-35. doi:10.1016/S0140-6736(14)60525-0.</mixed-citation><mixed-citation xml:lang="en">Schröder FH, Hugosson J, Roobol MJ, et al. Screening and prostate cancer mortality: results of the European Randomised Study of Screening for Prostate Cancer (ERSPC) at 13 years of follow-up. Lancet. 2014;384(9959):2027-35. doi:10.1016/S0140-6736(14)60525-0.</mixed-citation></citation-alternatives></ref><ref id="cit54"><label>54</label><citation-alternatives><mixed-citation xml:lang="ru">Pinsky PF, Miller E, Prorok P, et al. Extended follow-up for prostate cancer incidence and mortality among participants in the Prostate, Lung, Colorectal and Ovarian randomized cancer screening trial. BJU Int. 2019;123(5):854-60. doi:10.1111/bju.14580.</mixed-citation><mixed-citation xml:lang="en">Pinsky PF, Miller E, Prorok P, et al. Extended follow-up for prostate cancer incidence and mortality among participants in the Prostate, Lung, Colorectal and Ovarian randomized cancer screening trial. BJU Int. 2019;123(5):854-60. doi:10.1111/bju.14580.</mixed-citation></citation-alternatives></ref><ref id="cit55"><label>55</label><citation-alternatives><mixed-citation xml:lang="ru">Catalona WJ. Prostate Cancer Screening. Med Clin North Am. 2018;102(2):199-214. doi:10.1016/j.mcna.2017.11.001.</mixed-citation><mixed-citation xml:lang="en">Catalona WJ. Prostate Cancer Screening. Med Clin North Am. 2018;102(2):199-214. doi:10.1016/j.mcna.2017.11.001.</mixed-citation></citation-alternatives></ref><ref id="cit56"><label>56</label><citation-alternatives><mixed-citation xml:lang="ru">Martin RM, Donovan JL, Turner EL, et al. Effect of a Low-Intensity PSA-Based Screening Intervention on Prostate Cancer Mortality: The CAP Randomized Clinical Trial. JAMA. 2018;319(9):883-95. doi:10.1001/jama.2018.0154.</mixed-citation><mixed-citation xml:lang="en">Martin RM, Donovan JL, Turner EL, et al. Effect of a Low-Intensity PSA-Based Screening Intervention on Prostate Cancer Mortality: The CAP Randomized Clinical Trial. JAMA. 2018;319(9):883-95. doi:10.1001/jama.2018.0154.</mixed-citation></citation-alternatives></ref><ref id="cit57"><label>57</label><citation-alternatives><mixed-citation xml:lang="ru">Babaian RJ, Johnston DA, Naccarato W, et al. The incidence of prostate cancer in a screening population with a serum prostate specific antigen between 2.5 and 4.0 ng./ml.: relation to biopsy strategy. J Urol. 2001;165(3):757-60.</mixed-citation><mixed-citation xml:lang="en">Babaian RJ, Johnston DA, Naccarato W, et al. The incidence of prostate cancer in a screening population with a serum prostate specific antigen between 2.5 and 4.0 ng./ml.: relation to biopsy strategy. J Urol. 2001;165(3):757-60.</mixed-citation></citation-alternatives></ref><ref id="cit58"><label>58</label><citation-alternatives><mixed-citation xml:lang="ru">Meeks JJ, Loeb S, Helfand BT, et al. Characteristics of prostate cancers detected at prostate specific antigen levels less than 2.5 ng/ml. J Urol. 2009;181(6):2515-8; discussion 2518-9. doi:10.1016/j.juro.2009.01.102.</mixed-citation><mixed-citation xml:lang="en">Meeks JJ, Loeb S, Helfand BT, et al. Characteristics of prostate cancers detected at prostate specific antigen levels less than 2.5 ng/ml. J Urol. 2009;181(6):2515-8; discussion 2518-9. doi:10.1016/j.juro.2009.01.102.</mixed-citation></citation-alternatives></ref><ref id="cit59"><label>59</label><citation-alternatives><mixed-citation xml:lang="ru">Ilic D, Neuberger MM, Djulbegovic M, Dahm P. Screening for prostate cancer. Cochrane Database Syst Rev. 2013;2013(1):CD004720. doi:10.1002/14651858.CD004720.pub3.</mixed-citation><mixed-citation xml:lang="en">Ilic D, Neuberger MM, Djulbegovic M, Dahm P. Screening for prostate cancer. Cochrane Database Syst Rev. 2013;2013(1):CD004720. doi:10.1002/14651858.CD004720.pub3.</mixed-citation></citation-alternatives></ref><ref id="cit60"><label>60</label><citation-alternatives><mixed-citation xml:lang="ru">Thompson IM, Pauler DK, Goodman PJ, et al. Prevalence of prostate cancer among men with a prostate-specific antigen level &lt; or =4.0 ng per milliliter. N Engl J Med. 2004;350(22):2239-46.</mixed-citation><mixed-citation xml:lang="en">Thompson IM, Pauler DK, Goodman PJ, et al. Prevalence of prostate cancer among men with a prostate-specific antigen level &lt; or =4.0 ng per milliliter. N Engl J Med. 2004;350(22):2239-46.</mixed-citation></citation-alternatives></ref><ref id="cit61"><label>61</label><citation-alternatives><mixed-citation xml:lang="ru">Vietri MT, D'Elia G, Caliendo G, et al. Hereditary Prostate Cancer: Genes Related, Target Therapy and Prevention. Int J Mol Sci. 2021;22(7):3753. doi:10.3390/ijms22073753.</mixed-citation><mixed-citation xml:lang="en">Vietri MT, D'Elia G, Caliendo G, et al. Hereditary Prostate Cancer: Genes Related, Target Therapy and Prevention. Int J Mol Sci. 2021;22(7):3753. doi:10.3390/ijms22073753.</mixed-citation></citation-alternatives></ref><ref id="cit62"><label>62</label><citation-alternatives><mixed-citation xml:lang="ru">Khatami F, Afsari R, Khajavi A, Aghamir SMK. Age limit for familial prostate cancer screening. Caspian J Intern Med. 2024;16(1):187-91. doi:10.22088/cjim.16.1.187.</mixed-citation><mixed-citation xml:lang="en">Khatami F, Afsari R, Khajavi A, Aghamir SMK. Age limit for familial prostate cancer screening. Caspian J Intern Med. 2024;16(1):187-91. doi:10.22088/cjim.16.1.187.</mixed-citation></citation-alternatives></ref><ref id="cit63"><label>63</label><citation-alternatives><mixed-citation xml:lang="ru">Richie JP, Catalona WJ, Ahmann FR, et al. Effect of patient age on early detection of prostate cancer with serum prostate-specific antigen and digital rectal examination. Urology. 1993;42(4):365-74. doi:10.1016/0090-4295(93)90359-i.</mixed-citation><mixed-citation xml:lang="en">Richie JP, Catalona WJ, Ahmann FR, et al. Effect of patient age on early detection of prostate cancer with serum prostate-specific antigen and digital rectal examination. Urology. 1993;42(4):365-74. doi:10.1016/0090-4295(93)90359-i.</mixed-citation></citation-alternatives></ref><ref id="cit64"><label>64</label><citation-alternatives><mixed-citation xml:lang="ru">Carvalhal GF, Smith DS, Mager DE, et al. Digital rectal examination for detecting prostate cancer at prostate specific antigen levels of 4 ng./ml. or less. J Urol. 1999;161(3):835-9.</mixed-citation><mixed-citation xml:lang="en">Carvalhal GF, Smith DS, Mager DE, et al. Digital rectal examination for detecting prostate cancer at prostate specific antigen levels of 4 ng./ml. or less. J Urol. 1999;161(3):835-9.</mixed-citation></citation-alternatives></ref><ref id="cit65"><label>65</label><citation-alternatives><mixed-citation xml:lang="ru">Gosselaar C, Roobol MJ, Roemeling S, Schröder FH. The role of the digital rectal examination in subsequent screening visits in the European randomized study of screening for prostate cancer (ERSPC), Rotterdam. Eur Urol. 2008;54(3):581-8. doi:10.1016/j.eururo.2008.03.104.</mixed-citation><mixed-citation xml:lang="en">Gosselaar C, Roobol MJ, Roemeling S, Schröder FH. The role of the digital rectal examination in subsequent screening visits in the European randomized study of screening for prostate cancer (ERSPC), Rotterdam. Eur Urol. 2008;54(3):581-8. doi:10.1016/j.eururo.2008.03.104.</mixed-citation></citation-alternatives></ref><ref id="cit66"><label>66</label><citation-alternatives><mixed-citation xml:lang="ru">Herrera-Caceres JO, Wettstein MS, Goldberg H, et al. Utility of digital rectal examination in a population with prostate cancer treated with active surveillance. Can Urol Assoc J. 2020;14(9):E453-E457. doi:10.5489/cuaj.6341.</mixed-citation><mixed-citation xml:lang="en">Herrera-Caceres JO, Wettstein MS, Goldberg H, et al. Utility of digital rectal examination in a population with prostate cancer treated with active surveillance. Can Urol Assoc J. 2020;14(9):E453-E457. doi:10.5489/cuaj.6341.</mixed-citation></citation-alternatives></ref><ref id="cit67"><label>67</label><citation-alternatives><mixed-citation xml:lang="ru">Okotie OT, Roehl KA, Han M, et al. Characteristics of prostate cancer detected by digital rectal examination only. Urology. 2007;70(6):1117-20. doi:10.1016/j.urology.2007.07.019.</mixed-citation><mixed-citation xml:lang="en">Okotie OT, Roehl KA, Han M, et al. Characteristics of prostate cancer detected by digital rectal examination only. Urology. 2007;70(6):1117-20. doi:10.1016/j.urology.2007.07.019.</mixed-citation></citation-alternatives></ref><ref id="cit68"><label>68</label><citation-alternatives><mixed-citation xml:lang="ru">Bratan F, Niaf E, Melodelima C, et al. Influence of imaging and histological factors on prostate cancer detection and localisation on multiparametric MRI: a prospective study. Eur Radiol. 2013;23(7):2019-29. doi:10.1007/s00330-013-2795-0.</mixed-citation><mixed-citation xml:lang="en">Bratan F, Niaf E, Melodelima C, et al. Influence of imaging and histological factors on prostate cancer detection and localisation on multiparametric MRI: a prospective study. Eur Radiol. 2013;23(7):2019-29. doi:10.1007/s00330-013-2795-0.</mixed-citation></citation-alternatives></ref><ref id="cit69"><label>69</label><citation-alternatives><mixed-citation xml:lang="ru">Barentsz JO, Richenberg J, Clements R, et al.; European Society of Urogenital Radiology. ESUR prostate MR guidelines 2012. Eur Radiol. 2012;22(4):746-57. doi:10.1007/s00330-011-2377-y.</mixed-citation><mixed-citation xml:lang="en">Barentsz JO, Richenberg J, Clements R, et al.; European Society of Urogenital Radiology. ESUR prostate MR guidelines 2012. Eur Radiol. 2012;22(4):746-57. doi:10.1007/s00330-011-2377-y.</mixed-citation></citation-alternatives></ref><ref id="cit70"><label>70</label><citation-alternatives><mixed-citation xml:lang="ru">Magnetta MJ, Casalino D, Heller MT. Imaging assessment of local recurrence of prostate cancer after radical prostatectomy. Abdom Radiol (New York). 2020;45(12):4073-83. doi:10.1007/s00261-020-02505-7.</mixed-citation><mixed-citation xml:lang="en">Magnetta MJ, Casalino D, Heller MT. Imaging assessment of local recurrence of prostate cancer after radical prostatectomy. Abdom Radiol (New York). 2020;45(12):4073-83. doi:10.1007/s00261-020-02505-7.</mixed-citation></citation-alternatives></ref><ref id="cit71"><label>71</label><citation-alternatives><mixed-citation xml:lang="ru">Panebianco V, Villeirs G, Weinreb JC, et al. Prostate Magnetic Resonance Imaging for Local Recurrence Reporting (PI-RR): International Consensus -based Guidelines on Multiparametric Magnetic Resonance Imaging for Prostate Cancer Recurrence after Radiation Therapy and Radical Prostatectomy. Eur Urol Oncol. 2021;4(6):868-76. doi:10.1186/s13014-016-0671-1.</mixed-citation><mixed-citation xml:lang="en">Panebianco V, Villeirs G, Weinreb JC, et al. Prostate Magnetic Resonance Imaging for Local Recurrence Reporting (PI-RR): International Consensus -based Guidelines on Multiparametric Magnetic Resonance Imaging for Prostate Cancer Recurrence after Radiation Therapy and Radical Prostatectomy. Eur Urol Oncol. 2021;4(6):868-76. doi:10.1186/s13014-016-0671-1.</mixed-citation></citation-alternatives></ref><ref id="cit72"><label>72</label><citation-alternatives><mixed-citation xml:lang="ru">Allen SD, Thompson A, Sohaib SA. The normal post-surgical anatomy of the male pelvis following radical prostatectomy as assessed by magnetic resonance imaging. Eur Radiol. 2008;18(6):1281-91. doi:10.1007/s00330-008-0867-3.</mixed-citation><mixed-citation xml:lang="en">Allen SD, Thompson A, Sohaib SA. The normal post-surgical anatomy of the male pelvis following radical prostatectomy as assessed by magnetic resonance imaging. Eur Radiol. 2008;18(6):1281-91. doi:10.1007/s00330-008-0867-3.</mixed-citation></citation-alternatives></ref><ref id="cit73"><label>73</label><citation-alternatives><mixed-citation xml:lang="ru">Mertan FV, Greer MD, Borofsky S, et al. Multiparametric Magnetic Resonance Imaging of Recurrent Prostate Cancer. Top Magn Reson Imaging. 2016;25(3):139-47. doi:10.1097/RMR.0000000000000088.</mixed-citation><mixed-citation xml:lang="en">Mertan FV, Greer MD, Borofsky S, et al. Multiparametric Magnetic Resonance Imaging of Recurrent Prostate Cancer. Top Magn Reson Imaging. 2016;25(3):139-47. doi:10.1097/RMR.0000000000000088.</mixed-citation></citation-alternatives></ref><ref id="cit74"><label>74</label><citation-alternatives><mixed-citation xml:lang="ru">Мищенко А.В., Рубцова Н.А., Алексеев Б.Я. и др. Система унифицированного подхода к интерпретации магнитно-резонансной томографии предстательной железы согласно руководству PI-RADSv2. Онкоурология. 2016;12(1):81-9. doi:10.17650/1726-9776-2016-12-1-81-89.</mixed-citation><mixed-citation xml:lang="en">Mishchenko AV, Rubtsova NA, Alekseev BYa, et al. A system of a unified approach to interpreting prostate magnetic resonance imaging according to the PI-RADSv2 guideline. Oncourology. 2016;12(1):81-9. (In Russ.) doi:10.17650/1726-9776-2016-12-1-81-89.</mixed-citation></citation-alternatives></ref><ref id="cit75"><label>75</label><citation-alternatives><mixed-citation xml:lang="ru">Patel P, Mathew MS, Trilisky I, Oto A. Multiparametric MR Imaging of the Prostate after Treatment of Prostate Cancer. Radiographics. 2018;38(2):437-49. doi:10.1148/rg.2018170147.</mixed-citation><mixed-citation xml:lang="en">Patel P, Mathew MS, Trilisky I, Oto A. Multiparametric MR Imaging of the Prostate after Treatment of Prostate Cancer. Radiographics. 2018;38(2):437-49. doi:10.1148/rg.2018170147.</mixed-citation></citation-alternatives></ref><ref id="cit76"><label>76</label><citation-alternatives><mixed-citation xml:lang="ru">Kowa JY, Soneji N, Sohaib SA, et al. Detection and staging of radio-recurrent prostate cancer using multiparametric MRI. Br J Radiol. 2021;94(1120):20201423. doi:10.1259/bjr.20201423.</mixed-citation><mixed-citation xml:lang="en">Kowa JY, Soneji N, Sohaib SA, et al. Detection and staging of radio-recurrent prostate cancer using multiparametric MRI. Br J Radiol. 2021;94(1120):20201423. doi:10.1259/bjr.20201423.</mixed-citation></citation-alternatives></ref><ref id="cit77"><label>77</label><citation-alternatives><mixed-citation xml:lang="ru">Рубцова Н.А., Мищенко А.В., Данилов В.В. и др. PI-RADS v2.1: движение на пути к ясности (комментарии к обновленной версии). Онкоурология. 2020;16(2):15-28. doi:10.17650/1726-9776-2020-16-2-15-28.</mixed-citation><mixed-citation xml:lang="en">Rubtsova NA, Mishchenko AV, Danilov VV, et al. PI-RADS v2.1: movement towards clarity (comments to the updated version). Oncourology. 2020;16(2):15-28. (In Russ.) doi:10.17650/1726-9776-2020-16-2-15-28.</mixed-citation></citation-alternatives></ref><ref id="cit78"><label>78</label><citation-alternatives><mixed-citation xml:lang="ru">Eklund M, Jäderling F, Discacciati Aet al.; STHLM3 consortium. MRI-Targeted or Standard Biopsy in Prostate Cancer Screening. N Engl J Med. 2021;385(10):908-20. doi:10.1056/NEJMoa2100852.</mixed-citation><mixed-citation xml:lang="en">Eklund M, Jäderling F, Discacciati Aet al.; STHLM3 consortium. MRI-Targeted or Standard Biopsy in Prostate Cancer Screening. N Engl J Med. 2021;385(10):908-20. doi:10.1056/NEJMoa2100852.</mixed-citation></citation-alternatives></ref><ref id="cit79"><label>79</label><citation-alternatives><mixed-citation xml:lang="ru">Eldred-Evans D, Ahmed HU. Population-Based Prostate Cancer Screening With Magnetic Resonance Imaging or Ultrasonography-The IP1-PROSTAGRAM StudyReply. JAMA Oncol. 2021;7(10):1575-6. doi:10.1001/jamaoncol.2021.2967.</mixed-citation><mixed-citation xml:lang="en">Eldred-Evans D, Ahmed HU. Population-Based Prostate Cancer Screening With Magnetic Resonance Imaging or Ultrasonography-The IP1-PROSTAGRAM StudyReply. JAMA Oncol. 2021;7(10):1575-6. doi:10.1001/jamaoncol.2021.2967.</mixed-citation></citation-alternatives></ref><ref id="cit80"><label>80</label><citation-alternatives><mixed-citation xml:lang="ru">Turkbey B, Rosenkrantz AB, Haider MA, et al. Prostate Imaging Reporting and Data System Version 2.1: 2019 Update of Prostate Imaging Reporting and Data System Version 2. Eur Urol. 2019;76(3):340-51. doi:10.1016/j.eururo.2019.02.033.</mixed-citation><mixed-citation xml:lang="en">Turkbey B, Rosenkrantz AB, Haider MA, et al. Prostate Imaging Reporting and Data System Version 2.1: 2019 Update of Prostate Imaging Reporting and Data System Version 2. Eur Urol. 2019;76(3):340-51. doi:10.1016/j.eururo.2019.02.033.</mixed-citation></citation-alternatives></ref><ref id="cit81"><label>81</label><citation-alternatives><mixed-citation xml:lang="ru">Correas JM, Halpern EJ, Barr RG, et al. Advanced ultrasound in the diagnosis of prostate cancer. World J Urol. 2021;39(3):661-76. doi:10.1007/s00345-020-03193-0.</mixed-citation><mixed-citation xml:lang="en">Correas JM, Halpern EJ, Barr RG, et al. Advanced ultrasound in the diagnosis of prostate cancer. World J Urol. 2021;39(3):661-76. doi:10.1007/s00345-020-03193-0.</mixed-citation></citation-alternatives></ref><ref id="cit82"><label>82</label><citation-alternatives><mixed-citation xml:lang="ru">Haider M, Leow JJ, Nordström T, et al. Emerging tools for the early detection of prostate cancer. BJUI Compass. 2025;6(9):e70081. doi:10.1002/bco2.70081.</mixed-citation><mixed-citation xml:lang="en">Haider M, Leow JJ, Nordström T, et al. Emerging tools for the early detection of prostate cancer. BJUI Compass. 2025;6(9):e70081. doi:10.1002/bco2.70081.</mixed-citation></citation-alternatives></ref><ref id="cit83"><label>83</label><citation-alternatives><mixed-citation xml:lang="ru">Grey ADR, Scott R, Shah B, et al. Multiparametric ultrasound versus multiparametric MRI to diagnose prostate cancer (CADMUS): a prospective, multicentre, pairedcohort, confirmatory study. Lancet Oncol. 2022;23(3):428-38. doi:10.1016/S1470-2045(22)00016-X.</mixed-citation><mixed-citation xml:lang="en">Grey ADR, Scott R, Shah B, et al. Multiparametric ultrasound versus multiparametric MRI to diagnose prostate cancer (CADMUS): a prospective, multicentre, pairedcohort, confirmatory study. Lancet Oncol. 2022;23(3):428-38. doi:10.1016/S1470-2045(22)00016-X.</mixed-citation></citation-alternatives></ref><ref id="cit84"><label>84</label><citation-alternatives><mixed-citation xml:lang="ru">Alghamdi D, Kernohan N, Li C, Nabi G. Comparative Assessment of Different Ultrasound Technologies in the Detection of Prostate Cancer: A Systematic Review and Meta-Analysis. Cancers (Basel). 2023;15(16):4105. doi:10.3390/cancers15164105.</mixed-citation><mixed-citation xml:lang="en">Alghamdi D, Kernohan N, Li C, Nabi G. Comparative Assessment of Different Ultrasound Technologies in the Detection of Prostate Cancer: A Systematic Review and Meta-Analysis. Cancers (Basel). 2023;15(16):4105. doi:10.3390/cancers15164105.</mixed-citation></citation-alternatives></ref><ref id="cit85"><label>85</label><citation-alternatives><mixed-citation xml:lang="ru">Liu D, Lin W, Wei C, et al. Exploring the potential clinical value of shear wave elastography in prostate cancer: a meta-analysis. BMC Cancer. 2025;25(1):1032. doi:10.1186/s12885-025-14414-3.</mixed-citation><mixed-citation xml:lang="en">Liu D, Lin W, Wei C, et al. Exploring the potential clinical value of shear wave elastography in prostate cancer: a meta-analysis. BMC Cancer. 2025;25(1):1032. doi:10.1186/s12885-025-14414-3.</mixed-citation></citation-alternatives></ref><ref id="cit86"><label>86</label><citation-alternatives><mixed-citation xml:lang="ru">Kinnaird A, Luger F, Cash H, et al.; OPTIMUM Investigators. MicroultrasonographyGuided vs MRI-Guided Biopsy for Prostate Cancer Diagnosis: The OPTIMUM Randomized Clinical Trial. JAMA. 2025;333(19):1679-87. doi:10.1001/jama.2025.3579.</mixed-citation><mixed-citation xml:lang="en">Kinnaird A, Luger F, Cash H, et al.; OPTIMUM Investigators. MicroultrasonographyGuided vs MRI-Guided Biopsy for Prostate Cancer Diagnosis: The OPTIMUM Randomized Clinical Trial. JAMA. 2025;333(19):1679-87. doi:10.1001/jama.2025.3579.</mixed-citation></citation-alternatives></ref><ref id="cit87"><label>87</label><citation-alternatives><mixed-citation xml:lang="ru">Кадрев А.В., Митькова М.Д., Амосов А.В. и др. Стандартизация протокола ультразвукового исследования предстательной железы у взрослых. Часть 2. Трансректальное ультразвуковое исследование предстательной железы. Консенсус экспертов Российской ассоциации специалистов ультразвуковой диагностики в медицине (РАСУДМ). Ультразвуковая и функциональная диагностика. 2023;(3):9-23. doi:10.24835/1607-0771-2023-3-9-23.</mixed-citation><mixed-citation xml:lang="en">Kadrev A.V., Mitkova M.D., Amosov A.V., Bulanov M.N., Vetsheva N.N., Gromov A.I., Ignashin N.S., Krupinov G.E., Mitina L.A., Sorokin N.I., Strokova L.A., Khitrova A.N., Shvyrev S.L., Mitkov V.V. Recommendations for prostate ultrasound in adults. Part II. Transrectal prostate ultrasound. An expert consensus statement from the Russian Association of Specialists in Ultrasound Diagnostics in Medicine (RASUDM). Ultrasound &amp; Functional Diagnostics. 2023;(3):9-23. (In Russ.) doi:10.24835/1607-0771-2023-3-9-23.</mixed-citation></citation-alternatives></ref><ref id="cit88"><label>88</label><citation-alternatives><mixed-citation xml:lang="ru">Rifkin MD, Dahnert W, Kurtz AB. State of the art: endorectal sonography of the prostate gland. AJR Am.J. Roentgenol. 1990;154(4):691-700. doi:10.2214/ajr.154.4.1690499.</mixed-citation><mixed-citation xml:lang="en">Rifkin MD, Dahnert W, Kurtz AB. State of the art: endorectal sonography of the prostate gland. AJR Am.J. Roentgenol. 1990;154(4):691-700. doi:10.2214/ajr.154.4.1690499.</mixed-citation></citation-alternatives></ref><ref id="cit89"><label>89</label><citation-alternatives><mixed-citation xml:lang="ru">Barr RG, Cosgrove D, Brock M, et al. WFUMB Guidelines and Recommendations on the Clinical Use of Ultrasound Elastography: Part 5. Prostate. Ultrasound Med Biol. 2017;43(1):27-48. doi:10.1016/j.ultrasmedbio.2016.06.020.</mixed-citation><mixed-citation xml:lang="en">Barr RG, Cosgrove D, Brock M, et al. WFUMB Guidelines and Recommendations on the Clinical Use of Ultrasound Elastography: Part 5. Prostate. Ultrasound Med Biol. 2017;43(1):27-48. doi:10.1016/j.ultrasmedbio.2016.06.020.</mixed-citation></citation-alternatives></ref><ref id="cit90"><label>90</label><citation-alternatives><mixed-citation xml:lang="ru">Săftoiu A, Gilja OH, Sidhu PS, et al. The EFSUMB Guidelines and Recommendations for the Clinical Practice of Elastography in Non-Hepatic Applications: Update 2018. Ultraschall Med. 2019;40(4):425-53. English. doi:10.1055/a-0838-9937.</mixed-citation><mixed-citation xml:lang="en">Săftoiu A, Gilja OH, Sidhu PS, et al. The EFSUMB Guidelines and Recommendations for the Clinical Practice of Elastography in Non-Hepatic Applications: Update 2018. Ultraschall Med. 2019;40(4):425-53. English. doi:10.1055/a-0838-9937.</mixed-citation></citation-alternatives></ref><ref id="cit91"><label>91</label><citation-alternatives><mixed-citation xml:lang="ru">Кадрев А.В., Митькова М.Д., Камалов А.А., Митьков В.В. Мультипараметрическая ультразвуковая диагностика рака предстательной железы. Ультразвуковая и функциональная диагностика. 2021;(3):37-70. doi:10.24835/1607-0771-2021-3-37-70.</mixed-citation><mixed-citation xml:lang="en">Kadrev A.V., Mitkova M.D., Kamalov A.A., Mitkov V.V. Multiparametric ultrasound in prostate cancer diagnosis. Ultrasound &amp; Functional Diagnostics. 2021;(3):37-70. (In Russ.) doi:10.24835/1607-0771-2021-3-37-70.</mixed-citation></citation-alternatives></ref><ref id="cit92"><label>92</label><citation-alternatives><mixed-citation xml:lang="ru">Catalona WJ, Partin AW, Slawin KM, et al. Use of the Percentage of Free Prostate-Specific Antigen to Enhance Differentiation of Prostate Cancer From Benign Prostatic DiseaseUse of the percentage of free prostate-specific antigen to enhance differentiation of prostate cancer from benign prostatic disease: a prospective multicenter clinical trial. JAMA. 1998;279(19):1542-7.</mixed-citation><mixed-citation xml:lang="en">Catalona WJ, Partin AW, Slawin KM, et al. Use of the Percentage of Free Prostate-Specific Antigen to Enhance Differentiation of Prostate Cancer From Benign Prostatic DiseaseUse of the percentage of free prostate-specific antigen to enhance differentiation of prostate cancer from benign prostatic disease: a prospective multicenter clinical trial. JAMA. 1998;279(19):1542-7.</mixed-citation></citation-alternatives></ref><ref id="cit93"><label>93</label><citation-alternatives><mixed-citation xml:lang="ru">Partin AW, Brawer MK, Subong EN, et al. Prospective evaluation of percent freePSA and complexed-PSA for early detection of prostate cancer. Prostate Cancer Prostatic Dis. 1998;1(4):197-203. doi:10.1038/sj.pcan.4500232.</mixed-citation><mixed-citation xml:lang="en">Partin AW, Brawer MK, Subong EN, et al. Prospective evaluation of percent freePSA and complexed-PSA for early detection of prostate cancer. Prostate Cancer Prostatic Dis. 1998;1(4):197-203. doi:10.1038/sj.pcan.4500232.</mixed-citation></citation-alternatives></ref><ref id="cit94"><label>94</label><citation-alternatives><mixed-citation xml:lang="ru">Benson MC, Whang IS, Pantuck A, et al. WH. Prostate specific antigen density: a means of distinguishing benign prostatic hypertrophy and prostate cancer. J Urol. 1992;147(3 Pt 2):815-6.</mixed-citation><mixed-citation xml:lang="en">Benson MC, Whang IS, Pantuck A, et al. WH. Prostate specific antigen density: a means of distinguishing benign prostatic hypertrophy and prostate cancer. J Urol. 1992;147(3 Pt 2):815-6.</mixed-citation></citation-alternatives></ref><ref id="cit95"><label>95</label><citation-alternatives><mixed-citation xml:lang="ru">Пушкарь Д.Ю., Говоров А.В., Сидоренков А.В. и др. Ранняя диагностика рака предстательной железы. Методические рекомендации № 19. М.: ООО Издательский дом "АБВ-пресс", 2015. 52 с. EDN: KMFWSZ.</mixed-citation><mixed-citation xml:lang="en">Pushkar DYu, Govorov AV, Sidorenkov AV, et al. Early diagnosis of prostate cancer. Methodological recommendations No. 19. Moscow: ABC-Press Publishing House, 2015. 52 p. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit96"><label>96</label><citation-alternatives><mixed-citation xml:lang="ru">Mikolajczyk SD, Grauer LS, Millar LS, et al. A precursor form of PSA (pPSA) is a component of the free PSA in prostate cancer serum. Urology. 1997;50(5):710-4. doi:10.1016/S0090-4295(97)00449-4.</mixed-citation><mixed-citation xml:lang="en">Mikolajczyk SD, Grauer LS, Millar LS, et al. A precursor form of PSA (pPSA) is a component of the free PSA in prostate cancer serum. Urology. 1997;50(5):710-4. doi:10.1016/S0090-4295(97)00449-4.</mixed-citation></citation-alternatives></ref><ref id="cit97"><label>97</label><citation-alternatives><mixed-citation xml:lang="ru">Catalona WJ, Bartsch G, Rittenhouse HG, et al. Serum pro-prostate specific antigen preferentially detects aggressive prostate cancers in men with 2 to 4 ng/ml prostate specific antigen. J Urol. 2004;171(6 Pt 1):2239-44.</mixed-citation><mixed-citation xml:lang="en">Catalona WJ, Bartsch G, Rittenhouse HG, et al. Serum pro-prostate specific antigen preferentially detects aggressive prostate cancers in men with 2 to 4 ng/ml prostate specific antigen. J Urol. 2004;171(6 Pt 1):2239-44.</mixed-citation></citation-alternatives></ref><ref id="cit98"><label>98</label><citation-alternatives><mixed-citation xml:lang="ru">Catalona WJ, Partin AW, Sanda MG, et al. A multicenter study of [-2]pro-prostate specific antigen combined with prostate specific antigen and free prostate specific antigen for prostate cancer detection in the 2.0 to 10.0 ng/ml prostate specific antigen range. J Urol. 2011;185(5):1650-5. doi:10.1016/j.juro.2010.12.032.</mixed-citation><mixed-citation xml:lang="en">Catalona WJ, Partin AW, Sanda MG, et al. A multicenter study of [-2]pro-prostate specific antigen combined with prostate specific antigen and free prostate specific antigen for prostate cancer detection in the 2.0 to 10.0 ng/ml prostate specific antigen range. J Urol. 2011;185(5):1650-5. doi:10.1016/j.juro.2010.12.032.</mixed-citation></citation-alternatives></ref><ref id="cit99"><label>99</label><citation-alternatives><mixed-citation xml:lang="ru">Guazzoni G, Lazzeri M, Nava L, et al. Preoperative prostate-specific antigen isoform p2PSA and its derivatives, %p2PSA and prostate health index, predict pathologic outcomes in patients undergoing radical prostatectomy for prostate cancer Eur Urol. 2012;61(3):455-66. doi:10.1016/j.eururo.2011.10.038.</mixed-citation><mixed-citation xml:lang="en">Guazzoni G, Lazzeri M, Nava L, et al. Preoperative prostate-specific antigen isoform p2PSA and its derivatives, %p2PSA and prostate health index, predict pathologic outcomes in patients undergoing radical prostatectomy for prostate cancer Eur Urol. 2012;61(3):455-66. doi:10.1016/j.eururo.2011.10.038.</mixed-citation></citation-alternatives></ref><ref id="cit100"><label>100</label><citation-alternatives><mixed-citation xml:lang="ru">Stephan C, Vincendeau S, Houlgatte A, et al. Multicenter evaluation of [-2] proprostate-specific antigen and the prostate health index for detecting prostate cancer. Clin Chem. 2013;59(1):306-14. doi:10.1373/clinchem.2012.195784.</mixed-citation><mixed-citation xml:lang="en">Stephan C, Vincendeau S, Houlgatte A, et al. Multicenter evaluation of [-2] proprostate-specific antigen and the prostate health index for detecting prostate cancer. Clin Chem. 2013;59(1):306-14. doi:10.1373/clinchem.2012.195784.</mixed-citation></citation-alternatives></ref><ref id="cit101"><label>101</label><citation-alternatives><mixed-citation xml:lang="ru">Ружанская А.В., Евгина С.А., Скибо И.И. Практическое использование маркера -2пропса и индекса здоровья простаты phi в диагностике рака предстательной железы Клиническая лабораторная диагностика. 2014;(1):4-8.</mixed-citation><mixed-citation xml:lang="en">Ruzhanskaya AV, Evgenina SA, Skibo II. Practical use of marker -2props and prostate health index phi in the diagnosis of prostate cancer Clinical laboratory diagnostics. 2014;(1):4-8. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit102"><label>102</label><citation-alternatives><mixed-citation xml:lang="ru">Рапопорт Л.М., Безруков Е.А., Суханов Р.Б. и др. Биомаркеры рака предстательной железы: настоящее и будущее. Андрология и генитальная хирургия 2018;19(1):66-74. doi:10.17650/2070-9781-2018-19-1-68-76.</mixed-citation><mixed-citation xml:lang="en">Rapoport LM, Bezrukov EA, Sukhanov RB, et al. Biomarkers for diagnosing of prostate cancer: the present and the future. Andrology and Genital Surgery. 2018;19(1):68-76. (In Russ.) doi:10.17650/2070-9781-2018-19-1-68-76.</mixed-citation></citation-alternatives></ref><ref id="cit103"><label>103</label><citation-alternatives><mixed-citation xml:lang="ru">Fradet Y, Saad F, Aprikian A, et al. uPM3, a new molecular urine test for the detection of prostate cancer. Urology. 2004;64(2):311-5. doi:10.1016/j.urology.2004.03.052.</mixed-citation><mixed-citation xml:lang="en">Fradet Y, Saad F, Aprikian A, et al. uPM3, a new molecular urine test for the detection of prostate cancer. Urology. 2004;64(2):311-5. doi:10.1016/j.urology.2004.03.052.</mixed-citation></citation-alternatives></ref><ref id="cit104"><label>104</label><citation-alternatives><mixed-citation xml:lang="ru">Абоян И.А., Федотова Е.Н., Шевченко А.Н. и др. Современные биомаркеры рака предстательной железы. Исследования и практика в медицине. 2021;8(4): 96-108. doi:10.17709/2410-1893-2021-8-4-10.</mixed-citation><mixed-citation xml:lang="en">Aboian IA, Fedotova EN, Shevchenko AN, et al. Current biomarkers of prostate cancer. Research and Practical Medicine Journal. 2021;8(4):96-108. (In Russ.) doi:10.17709/2410-1893-2021-8-4-10.</mixed-citation></citation-alternatives></ref><ref id="cit105"><label>105</label><citation-alternatives><mixed-citation xml:lang="ru">Попов С.В., Гусейнов Р. Г., Васин А.В. и др. Современное представление о биомаркерах рака предстательной железы. Онкоурология 2023;19(4):148-57. doi:10.17650/1726-9776-2023-19-4-148-157.</mixed-citation><mixed-citation xml:lang="en">Popov SV, Guseynov RG, Vasin AV, et al. Current understanding of prostate cancer biomarkers. Cancer Urology. 2023;19(4):148-57. (In Russ.) doi:10.17650/1726-9776-2023-19-4-148-157.</mixed-citation></citation-alternatives></ref><ref id="cit106"><label>106</label><citation-alternatives><mixed-citation xml:lang="ru">Vickers AJ, Cronin AM, Aus G, et al. A panel of kallikrein markers can reduce unnecessary biopsy for prostate cancer: data from the European Randomized Study of Prostate Cancer Screening in Göteborg, Sweden. BMC Med. 2008;6:19. doi: 10.1186/1741-7015-6-19.</mixed-citation><mixed-citation xml:lang="en">Vickers AJ, Cronin AM, Aus G, et al. A panel of kallikrein markers can reduce unnecessary biopsy for prostate cancer: data from the European Randomized Study of Prostate Cancer Screening in Göteborg, Sweden. BMC Med. 2008;6:19. doi: 10.1186/1741-7015-6-19.</mixed-citation></citation-alternatives></ref><ref id="cit107"><label>107</label><citation-alternatives><mixed-citation xml:lang="ru">Parekh DJ, Punnen S, Sjoberg DD, et al. A multi-institutional prospective trial in the USA confirms that the 4Kscore accurately identifies men with high-grade prostate cancer. Eur Urol 2015;68(3):464-70. doi:10.1016/j.eururo.2014.10.021.</mixed-citation><mixed-citation xml:lang="en">Parekh DJ, Punnen S, Sjoberg DD, et al. A multi-institutional prospective trial in the USA confirms that the 4Kscore accurately identifies men with high-grade prostate cancer. Eur Urol 2015;68(3):464-70. doi:10.1016/j.eururo.2014.10.021.</mixed-citation></citation-alternatives></ref><ref id="cit108"><label>108</label><citation-alternatives><mixed-citation xml:lang="ru">Kanwal R, Plaga AR, Liu X, et al. MicroRNAs in prostate cancer: Functional role as biomarkers. Cancer Lett. 2017;407:9–20. doi:10.1016/j.canlet.2017.08.011.</mixed-citation><mixed-citation xml:lang="en">Kanwal R, Plaga AR, Liu X, et al. MicroRNAs in prostate cancer: Functional role as biomarkers. Cancer Lett. 2017;407:9–20. doi:10.1016/j.canlet.2017.08.011.</mixed-citation></citation-alternatives></ref><ref id="cit109"><label>109</label><citation-alternatives><mixed-citation xml:lang="ru">Sharma N, Baruah MM. The microRNA signatures: aberrantly expressed miRNAs in prostate cancer. Clin Transl Oncol. 2019;21(2):126-44. doi:10.1007/s12094-018-1910-8.</mixed-citation><mixed-citation xml:lang="en">Sharma N, Baruah MM. The microRNA signatures: aberrantly expressed miRNAs in prostate cancer. Clin Transl Oncol. 2019;21(2):126-44. doi:10.1007/s12094-018-1910-8.</mixed-citation></citation-alternatives></ref><ref id="cit110"><label>110</label><citation-alternatives><mixed-citation xml:lang="ru">Bautista-Sánchez D., Arriaga-Canon C., Pedroza-Torres A. et al. The promising role of miR-21 as a cancer biomarker and its importance in RNA-based therapeutics. Mol Ther Nucleic Acids. 2020;20:409-20. doi:10.1016/j.omtn.2020.03.003.</mixed-citation><mixed-citation xml:lang="en">Bautista-Sánchez D., Arriaga-Canon C., Pedroza-Torres A. et al. The promising role of miR-21 as a cancer biomarker and its importance in RNA-based therapeutics. Mol Ther Nucleic Acids. 2020;20:409-20. doi:10.1016/j.omtn.2020.03.003.</mixed-citation></citation-alternatives></ref><ref id="cit111"><label>111</label><citation-alternatives><mixed-citation xml:lang="ru">Spratt DE, Srinivas S, Adra N, et al. Prostate Cancer, Version 3.2026, NCCN Clinical Practice Guidelines In Oncology. J Natl Compr Canc Netw. 2025;23(11):469-93. doi:10.6004/jnccn.2025.0052.</mixed-citation><mixed-citation xml:lang="en">Spratt DE, Srinivas S, Adra N, et al. Prostate Cancer, Version 3.2026, NCCN Clinical Practice Guidelines In Oncology. J Natl Compr Canc Netw. 2025;23(11):469-93. doi:10.6004/jnccn.2025.0052.</mixed-citation></citation-alternatives></ref><ref id="cit112"><label>112</label><citation-alternatives><mixed-citation xml:lang="ru">Jain MA, Leslie SW, Sapra A. Prostate Cancer Screening. [Updated 2023 Oct 26]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2026 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK556081.</mixed-citation><mixed-citation xml:lang="en">Jain MA, Leslie SW, Sapra A. Prostate Cancer Screening. [Updated 2023 Oct 26]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2026 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK556081.</mixed-citation></citation-alternatives></ref><ref id="cit113"><label>113</label><citation-alternatives><mixed-citation xml:lang="ru">Sarkar RR, Parsons JK, Bryant AK, et al. Association of Treatment With 5αReductase Inhibitors With Time to Diagnosis and Mortality in Prostate Cancer. JAMA Intern Med. 2019;179(6):812-9. doi:10.1001/jamainternmed.2019.0280.</mixed-citation><mixed-citation xml:lang="en">Sarkar RR, Parsons JK, Bryant AK, et al. Association of Treatment With 5αReductase Inhibitors With Time to Diagnosis and Mortality in Prostate Cancer. JAMA Intern Med. 2019;179(6):812-9. doi:10.1001/jamainternmed.2019.0280.</mixed-citation></citation-alternatives></ref><ref id="cit114"><label>114</label><citation-alternatives><mixed-citation xml:lang="ru">Andriole GL, Guess HA, Epstein JI, et al. Treatment with finasteride reserves usefulness of prostate-specific antigen in the detection of prostate cancer: results of a randomized, double-blind, placebo-controlled clinical trial. PLESS Study Group. Proscar Long-term Efficacy and Safety Study. Urology. 1998;52(2):195-201. doi:10.1016/S0090-4295(98)00184-8.</mixed-citation><mixed-citation xml:lang="en">Andriole GL, Guess HA, Epstein JI, et al. Treatment with finasteride reserves usefulness of prostate-specific antigen in the detection of prostate cancer: results of a randomized, double-blind, placebo-controlled clinical trial. PLESS Study Group. Proscar Long-term Efficacy and Safety Study. Urology. 1998;52(2):195-201. doi:10.1016/S0090-4295(98)00184-8.</mixed-citation></citation-alternatives></ref><ref id="cit115"><label>115</label><citation-alternatives><mixed-citation xml:lang="ru">Andriole GL, Bostwick DG, Brawley OW, et al.; REDUCE Study Group. Effect of dutasteride on the risk of prostate cancer. N Engl J Med. 2010;362(13):1192-202. doi:10.1056/NEJMoa0908127.</mixed-citation><mixed-citation xml:lang="en">Andriole GL, Bostwick DG, Brawley OW, et al.; REDUCE Study Group. Effect of dutasteride on the risk of prostate cancer. N Engl J Med. 2010;362(13):1192-202. doi:10.1056/NEJMoa0908127.</mixed-citation></citation-alternatives></ref><ref id="cit116"><label>116</label><citation-alternatives><mixed-citation xml:lang="ru">Lilja H, Cronin A.M, Dahlin A, et al. Prediction of significant prostate cancer diagnosed 20 to 30 years later with a single measure of prostate-specific antigen at or before age 50. Cancer. 2011;117(6):1210-9. doi:10.1002/cncr.25568.</mixed-citation><mixed-citation xml:lang="en">Lilja H, Cronin A.M, Dahlin A, et al. Prediction of significant prostate cancer diagnosed 20 to 30 years later with a single measure of prostate-specific antigen at or before age 50. Cancer. 2011;117(6):1210-9. doi:10.1002/cncr.25568.</mixed-citation></citation-alternatives></ref><ref id="cit117"><label>117</label><citation-alternatives><mixed-citation xml:lang="ru">Kovac E, Carlsson SV, Lilja H, et al. Association of Baseline Prostate-Specific Antigen Level With Long-term Diagnosis of Clinically Significant Prostate Cancer Among Patients Aged 55 to 60 Years. JAMA Netw Open. 2020;3(1):e1919284. doi:10.1001/jamanetworkopen.2019.19284.</mixed-citation><mixed-citation xml:lang="en">Kovac E, Carlsson SV, Lilja H, et al. Association of Baseline Prostate-Specific Antigen Level With Long-term Diagnosis of Clinically Significant Prostate Cancer Among Patients Aged 55 to 60 Years. JAMA Netw Open. 2020;3(1):e1919284. doi:10.1001/jamanetworkopen.2019.19284.</mixed-citation></citation-alternatives></ref><ref id="cit118"><label>118</label><citation-alternatives><mixed-citation xml:lang="ru">Carter HB. Prostate cancers in men with low PSA levels — must we find them? N Engl J Med. 2004;350(22):2292-4. doi:10.1056/NEJMe048003.</mixed-citation><mixed-citation xml:lang="en">Carter HB. Prostate cancers in men with low PSA levels — must we find them? N Engl J Med. 2004;350(22):2292-4. doi:10.1056/NEJMe048003.</mixed-citation></citation-alternatives></ref><ref id="cit119"><label>119</label><citation-alternatives><mixed-citation xml:lang="ru">Albright F, Stephenson RA, Agarwal N, et al. Prostate cancer risk prediction based on complete prostate cancer family history. Prostate. 2015;75(4):390-8. doi:10.1002/pros.22925.</mixed-citation><mixed-citation xml:lang="en">Albright F, Stephenson RA, Agarwal N, et al. Prostate cancer risk prediction based on complete prostate cancer family history. Prostate. 2015;75(4):390-8. doi:10.1002/pros.22925.</mixed-citation></citation-alternatives></ref><ref id="cit120"><label>120</label><citation-alternatives><mixed-citation xml:lang="ru">Grill S, Fallah M, Leach RJ, et al. Incorporation of detailed family history from the Swedish Family Cancer Database into the PCPT risk calculator. J Urol. 2015;193:460-5. doi:10.1016/j.juro.2014.09.018.</mixed-citation><mixed-citation xml:lang="en">Grill S, Fallah M, Leach RJ, et al. Incorporation of detailed family history from the Swedish Family Cancer Database into the PCPT risk calculator. J Urol. 2015;193:460-5. doi:10.1016/j.juro.2014.09.018.</mixed-citation></citation-alternatives></ref><ref id="cit121"><label>121</label><citation-alternatives><mixed-citation xml:lang="ru">Franz T, Stolzenburg JU. Clinical Relevance of Digital Rectal Examination in Men With Low and Very Low Prostate-Specific Antigen (PSA): Reassessing Its Diagnostic Value in the MRI Era and in Light of Modern Guidelines. Cureus. 2025;17(12):e99145. doi:10.7759/cureus.99145.</mixed-citation><mixed-citation xml:lang="en">Franz T, Stolzenburg JU. Clinical Relevance of Digital Rectal Examination in Men With Low and Very Low Prostate-Specific Antigen (PSA): Reassessing Its Diagnostic Value in the MRI Era and in Light of Modern Guidelines. Cureus. 2025;17(12):e99145. doi:10.7759/cureus.99145.</mixed-citation></citation-alternatives></ref><ref id="cit122"><label>122</label><citation-alternatives><mixed-citation xml:lang="ru">Thompson IM, Ankerst DP, Chi C, et al. Operating characteristics of prostatespecific antigen in men with an initial PSA level of 3.0 ng/ml or lower. JAMA. 2005;294(1):66-70. doi:10.1001/jama.294.1.66.</mixed-citation><mixed-citation xml:lang="en">Thompson IM, Ankerst DP, Chi C, et al. Operating characteristics of prostatespecific antigen in men with an initial PSA level of 3.0 ng/ml or lower. JAMA. 2005;294(1):66-70. doi:10.1001/jama.294.1.66.</mixed-citation></citation-alternatives></ref><ref id="cit123"><label>123</label><citation-alternatives><mixed-citation xml:lang="ru">Leitzmann MF, Rohrmann S.Risk factors for the onset of prostatic cancer: age, location, and behavioral correlates. Clin Epidemiol. 2012;4:1-11. doi:10.2147/CLEP.S16747.</mixed-citation><mixed-citation xml:lang="en">Leitzmann MF, Rohrmann S.Risk factors for the onset of prostatic cancer: age, location, and behavioral correlates. Clin Epidemiol. 2012;4:1-11. doi:10.2147/CLEP.S16747.</mixed-citation></citation-alternatives></ref><ref id="cit124"><label>124</label><citation-alternatives><mixed-citation xml:lang="ru">Mano R, Tamir S, Kedar I, et al. Malignant Abnormalities in Male BRCA Mutation Carriers: Results From a Prospectively Screened Cohort. JAMA Oncol. 2018;4(6):872-4. doi:10.1001/jamaoncol.2018.0271.</mixed-citation><mixed-citation xml:lang="en">Mano R, Tamir S, Kedar I, et al. Malignant Abnormalities in Male BRCA Mutation Carriers: Results From a Prospectively Screened Cohort. JAMA Oncol. 2018;4(6):872-4. doi:10.1001/jamaoncol.2018.0271.</mixed-citation></citation-alternatives></ref><ref id="cit125"><label>125</label><citation-alternatives><mixed-citation xml:lang="ru">Carroll PR, Parsons JK, Andriole GL, et al. NCCN Guidelines Insights: Prostate Cancer Early Detection, Version 2.2016. J Natl Compr Canc Netw. 2016;14(5):509-19. doi:10.6004/jnccn.2016.0060.</mixed-citation><mixed-citation xml:lang="en">Carroll PR, Parsons JK, Andriole GL, et al. NCCN Guidelines Insights: Prostate Cancer Early Detection, Version 2.2016. J Natl Compr Canc Netw. 2016;14(5):509-19. doi:10.6004/jnccn.2016.0060.</mixed-citation></citation-alternatives></ref><ref id="cit126"><label>126</label><citation-alternatives><mixed-citation xml:lang="ru">Wen J, Liu W, Shen X, Hu W. PI-RADS v2.1 and PSAD for the prediction of clinically significant prostate cancer among patients with PSA levels of 4-10 ng/ml. Sci Rep. 2024;14(1):6570. doi:10.1038/s41598-024-57337-y.</mixed-citation><mixed-citation xml:lang="en">Wen J, Liu W, Shen X, Hu W. PI-RADS v2.1 and PSAD for the prediction of clinically significant prostate cancer among patients with PSA levels of 4-10 ng/ml. Sci Rep. 2024;14(1):6570. doi:10.1038/s41598-024-57337-y.</mixed-citation></citation-alternatives></ref><ref id="cit127"><label>127</label><citation-alternatives><mixed-citation xml:lang="ru">Li Y, Wang S, Wang J, et al. PI-RADSv2.1 combined with PSA density for optimizing prostate biopsy decisions: a retrospective analysis. Front Oncol. 2025;15:1602412. doi:10.3389/fonc.2025.1602412.</mixed-citation><mixed-citation xml:lang="en">Li Y, Wang S, Wang J, et al. PI-RADSv2.1 combined with PSA density for optimizing prostate biopsy decisions: a retrospective analysis. Front Oncol. 2025;15:1602412. doi:10.3389/fonc.2025.1602412.</mixed-citation></citation-alternatives></ref><ref id="cit128"><label>128</label><citation-alternatives><mixed-citation xml:lang="ru">Ahmed HU, El-Shater Bosaily A, Brown LC, et al. Diagnostic accuracy of multiparametric MRI and TRUS biopsy in prostate cancer (PROMIS): a paired validating confirmatory study. Lancet. 2017;389:815-22. doi:10.1016/S0140-6736(16)32401-1.</mixed-citation><mixed-citation xml:lang="en">Ahmed HU, El-Shater Bosaily A, Brown LC, et al. Diagnostic accuracy of multiparametric MRI and TRUS biopsy in prostate cancer (PROMIS): a paired validating confirmatory study. Lancet. 2017;389:815-22. doi:10.1016/S0140-6736(16)32401-1.</mixed-citation></citation-alternatives></ref><ref id="cit129"><label>129</label><citation-alternatives><mixed-citation xml:lang="ru">Elkhoury FF, Felker ER, Kwan L, et al. Comparison of Targeted vs Systematic Prostate Biopsy in Men Who Are Biopsy Naive: The Prospective Assessment of Image Registration in the Diagnosis of Prostate Cancer (PAIREDCAP) Study. JAMA Surg. 2019;154(9):811-8. doi:10.1001/jamasurg.2019.1734.</mixed-citation><mixed-citation xml:lang="en">Elkhoury FF, Felker ER, Kwan L, et al. Comparison of Targeted vs Systematic Prostate Biopsy in Men Who Are Biopsy Naive: The Prospective Assessment of Image Registration in the Diagnosis of Prostate Cancer (PAIREDCAP) Study. JAMA Surg. 2019;154(9):811-8. doi:10.1001/jamasurg.2019.1734.</mixed-citation></citation-alternatives></ref><ref id="cit130"><label>130</label><citation-alternatives><mixed-citation xml:lang="ru">Ahdoot M, Wilbur AR, Reese SE, et al. MRI-Targeted, Systematic, and Combined Biopsy for Prostate Cancer Diagnosis. N Engl J Med. 2020;382(10):917-28. doi:10.1056/NEJMoa1910038.</mixed-citation><mixed-citation xml:lang="en">Ahdoot M, Wilbur AR, Reese SE, et al. MRI-Targeted, Systematic, and Combined Biopsy for Prostate Cancer Diagnosis. N Engl J Med. 2020;382(10):917-28. doi:10.1056/NEJMoa1910038.</mixed-citation></citation-alternatives></ref><ref id="cit131"><label>131</label><citation-alternatives><mixed-citation xml:lang="ru">Adhyam M, Gupta AK. A Review on the Clinical Utility of PSA in Cancer Prostate. Indian J Surg Oncol. 2012;3(2):120-9. doi:10.1007/s13193-012-0142-6.</mixed-citation><mixed-citation xml:lang="en">Adhyam M, Gupta AK. A Review on the Clinical Utility of PSA in Cancer Prostate. Indian J Surg Oncol. 2012;3(2):120-9. doi:10.1007/s13193-012-0142-6.</mixed-citation></citation-alternatives></ref><ref id="cit132"><label>132</label><citation-alternatives><mixed-citation xml:lang="ru">Herschman JD, Smith DS, Catalona WJ. Effect of ejaculation on serum total and free prostate-specific antigen concentrations. Urology. 1997;50(2):239-43. doi:10.1016/S0090-4295(97)00209-4.</mixed-citation><mixed-citation xml:lang="en">Herschman JD, Smith DS, Catalona WJ. Effect of ejaculation on serum total and free prostate-specific antigen concentrations. Urology. 1997;50(2):239-43. doi:10.1016/S0090-4295(97)00209-4.</mixed-citation></citation-alternatives></ref><ref id="cit133"><label>133</label><citation-alternatives><mixed-citation xml:lang="ru">Mejak SL, Bayliss J, Hanks SD. Long distance bicycle riding causes prostate-specific antigen to increase in men aged 50 years and over. PLoS One. 2013;8(2):e56030. doi:10.1371/journal.pone.0056030.</mixed-citation><mixed-citation xml:lang="en">Mejak SL, Bayliss J, Hanks SD. Long distance bicycle riding causes prostate-specific antigen to increase in men aged 50 years and over. PLoS One. 2013;8(2):e56030. doi:10.1371/journal.pone.0056030.</mixed-citation></citation-alternatives></ref><ref id="cit134"><label>134</label><citation-alternatives><mixed-citation xml:lang="ru">Oremek GM, Seiffert UB. Physical activity releases prostate-specific antigen (PSA) from the prostate gland into blood and increases serum PSA concentrations. Clin Chem. 1996;42(5):691-5.</mixed-citation><mixed-citation xml:lang="en">Oremek GM, Seiffert UB. Physical activity releases prostate-specific antigen (PSA) from the prostate gland into blood and increases serum PSA concentrations. Clin Chem. 1996;42(5):691-5.</mixed-citation></citation-alternatives></ref><ref id="cit135"><label>135</label><citation-alternatives><mixed-citation xml:lang="ru">Stimac G, Spajic B, Reljic A, et al. Effect of histological inflammation on total and free serum prostate-specific antigen values in patients without clinically detectable prostate cancer. Korean J Urol. 2014;55(8):527-32. doi:10.4111/kju.2014.55.8.527.</mixed-citation><mixed-citation xml:lang="en">Stimac G, Spajic B, Reljic A, et al. Effect of histological inflammation on total and free serum prostate-specific antigen values in patients without clinically detectable prostate cancer. Korean J Urol. 2014;55(8):527-32. doi:10.4111/kju.2014.55.8.527.</mixed-citation></citation-alternatives></ref><ref id="cit136"><label>136</label><citation-alternatives><mixed-citation xml:lang="ru">Kawakami J, Siemens DR, Nickel JC. Prostatitis and prostate cancer: implications for prostate cancer screening. Urology. 2004;64:1075. doi:10.1016/j.urology.2004.07.017.</mixed-citation><mixed-citation xml:lang="en">Kawakami J, Siemens DR, Nickel JC. Prostatitis and prostate cancer: implications for prostate cancer screening. Urology. 2004;64:1075. doi:10.1016/j.urology.2004.07.017.</mixed-citation></citation-alternatives></ref><ref id="cit137"><label>137</label><citation-alternatives><mixed-citation xml:lang="ru">Effect of digital rectal examination on serum prostate-specific antigen in a primary care setting. The Internal Medicine Clinic Research Consortium. Arch Intern Med. 1995;155(4):389-92.</mixed-citation><mixed-citation xml:lang="en">Effect of digital rectal examination on serum prostate-specific antigen in a primary care setting. The Internal Medicine Clinic Research Consortium. Arch Intern Med. 1995;155(4):389-92.</mixed-citation></citation-alternatives></ref><ref id="cit138"><label>138</label><citation-alternatives><mixed-citation xml:lang="ru">Yuan JJ, Coplen DE, Petros JA, et al. Effects of rectal examination, prostatic massage, ultrasonography and needle biopsy on serum prostate specific antigen levels. J Urol. 1992;147(3 Pt 2):810-4. doi:10.1016/s0022-5347(17)37392-5.</mixed-citation><mixed-citation xml:lang="en">Yuan JJ, Coplen DE, Petros JA, et al. Effects of rectal examination, prostatic massage, ultrasonography and needle biopsy on serum prostate specific antigen levels. J Urol. 1992;147(3 Pt 2):810-4. doi:10.1016/s0022-5347(17)37392-5.</mixed-citation></citation-alternatives></ref><ref id="cit139"><label>139</label><citation-alternatives><mixed-citation xml:lang="ru">Chybowski FM, Bergstralh EJ, Oesterling JE. The effect of digital rectal examination on the serum prostate specific antigen concentration: results of a randomized study. J Urol. 1992;148(1):83-6. doi:10.1016/s0022-5347(17)36517-5.</mixed-citation><mixed-citation xml:lang="en">Chybowski FM, Bergstralh EJ, Oesterling JE. The effect of digital rectal examination on the serum prostate specific antigen concentration: results of a randomized study. J Urol. 1992;148(1):83-6. doi:10.1016/s0022-5347(17)36517-5.</mixed-citation></citation-alternatives></ref><ref id="cit140"><label>140</label><citation-alternatives><mixed-citation xml:lang="ru">Bossens MM, Van Straalen JP, De Reijke TM, et al. Kinetics of prostate-specific antigen after manipulation of the prostate. Eur J Cancer. 1995;31A(5):682-5. doi:10.1016/0959-8049(95)00016-c.</mixed-citation><mixed-citation xml:lang="en">Bossens MM, Van Straalen JP, De Reijke TM, et al. Kinetics of prostate-specific antigen after manipulation of the prostate. Eur J Cancer. 1995;31A(5):682-5. doi:10.1016/0959-8049(95)00016-c.</mixed-citation></citation-alternatives></ref><ref id="cit141"><label>141</label><citation-alternatives><mixed-citation xml:lang="ru">Lechevallier E, Eghazarian C, Ortega JC, et al. Effect of digital rectal examination on serum complexed and free prostate-specific antigen and percentage of free prostatespecific antigen. Urology. 1999;54(5):857-61. doi:10.1016/s0090-4295(99)00239-3.</mixed-citation><mixed-citation xml:lang="en">Lechevallier E, Eghazarian C, Ortega JC, et al. Effect of digital rectal examination on serum complexed and free prostate-specific antigen and percentage of free prostatespecific antigen. Urology. 1999;54(5):857-61. doi:10.1016/s0090-4295(99)00239-3.</mixed-citation></citation-alternatives></ref><ref id="cit142"><label>142</label><citation-alternatives><mixed-citation xml:lang="ru">Maccini MA, Westfall NJ, Van Bokhoven A, et al. The effect of digital rectal exam on the 4Kscore for aggressive prostate cancer. Prostate. 2018;78(7):506-11. doi:10.1002/pros.23495.</mixed-citation><mixed-citation xml:lang="en">Maccini MA, Westfall NJ, Van Bokhoven A, et al. The effect of digital rectal exam on the 4Kscore for aggressive prostate cancer. Prostate. 2018;78(7):506-11. doi:10.1002/pros.23495.</mixed-citation></citation-alternatives></ref><ref id="cit143"><label>143</label><citation-alternatives><mixed-citation xml:lang="ru">Klomp ML, Hendrikx AJ, Keyzer JJ. The effect of transrectal ultrasonography (TRUS) including digital rectal examination (DRE) of the prostate on the level of prostate specific antigen (PSA). Br J Urol. 1994;73(1):71-4. doi:10.1111/j.1464-410x.1994.tb07459.x.</mixed-citation><mixed-citation xml:lang="en">Klomp ML, Hendrikx AJ, Keyzer JJ. The effect of transrectal ultrasonography (TRUS) including digital rectal examination (DRE) of the prostate on the level of prostate specific antigen (PSA). Br J Urol. 1994;73(1):71-4. doi:10.1111/j.1464-410x.1994.tb07459.x.</mixed-citation></citation-alternatives></ref><ref id="cit144"><label>144</label><citation-alternatives><mixed-citation xml:lang="ru">Serel TA, Cetin M, Delibaş N, et al. Effect of transrectal ultrasonography of the prostate on serum prostate-specific antigen levels and free/total prostate-specific antigen ratio. Urol Int. 2000;64(1):24-6. doi:10.1159/000030477.</mixed-citation><mixed-citation xml:lang="en">Serel TA, Cetin M, Delibaş N, et al. Effect of transrectal ultrasonography of the prostate on serum prostate-specific antigen levels and free/total prostate-specific antigen ratio. Urol Int. 2000;64(1):24-6. doi:10.1159/000030477.</mixed-citation></citation-alternatives></ref><ref id="cit145"><label>145</label><citation-alternatives><mixed-citation xml:lang="ru">Park SC, Shin YS, Zhang LT, et al. Prospective investigation of change in the prostate-specific antigens after various urologic procedures. Clin Interv Aging. 2015;10:1213-8. doi:10.2147/CIA.S84570.</mixed-citation><mixed-citation xml:lang="en">Park SC, Shin YS, Zhang LT, et al. Prospective investigation of change in the prostate-specific antigens after various urologic procedures. Clin Interv Aging. 2015;10:1213-8. doi:10.2147/CIA.S84570.</mixed-citation></citation-alternatives></ref><ref id="cit146"><label>146</label><citation-alternatives><mixed-citation xml:lang="ru">Klein LT, Lowe FC. The effects of prostatic manipulation on prostate-specific antigen levels. Urol Clin North Am. 1997;24(2):293-7. doi:10.1016/s0094-0143(05)70375-x.</mixed-citation><mixed-citation xml:lang="en">Klein LT, Lowe FC. The effects of prostatic manipulation on prostate-specific antigen levels. Urol Clin North Am. 1997;24(2):293-7. doi:10.1016/s0094-0143(05)70375-x.</mixed-citation></citation-alternatives></ref><ref id="cit147"><label>147</label><citation-alternatives><mixed-citation xml:lang="ru">Oesterling JE, Rice DC, Glenski WJ, Bergstralh EJ. Effect of cystoscopy, prostate biopsy, and transurethral resection of prostate on serum prostate-specific antigen concentration. Urology. 1993;42(3):276-82. doi:10.1016/0090-4295(93)90616-i.</mixed-citation><mixed-citation xml:lang="en">Oesterling JE, Rice DC, Glenski WJ, Bergstralh EJ. Effect of cystoscopy, prostate biopsy, and transurethral resection of prostate on serum prostate-specific antigen concentration. Urology. 1993;42(3):276-82. doi:10.1016/0090-4295(93)90616-i.</mixed-citation></citation-alternatives></ref><ref id="cit148"><label>148</label><citation-alternatives><mixed-citation xml:lang="ru">Cetinkaya ZA, Sezikli M, G zelbulut F, et al. Serum levels of prostate specific antigen are elevated after colonoscopy. Tohoku J Exp Med. 2010;222(3):183-6. doi:10.1620/tjem.222.183.</mixed-citation><mixed-citation xml:lang="en">Cetinkaya ZA, Sezikli M, G zelbulut F, et al. Serum levels of prostate specific antigen are elevated after colonoscopy. Tohoku J Exp Med. 2010;222(3):183-6. doi:10.1620/tjem.222.183.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
