<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">prmed</journal-id><journal-title-group><journal-title xml:lang="ru">Первичная медико-санитарная помощь</journal-title><trans-title-group xml:lang="en"><trans-title>Primary Health Care (Russian Federation)</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">3034-4123</issn><issn pub-type="epub">3034-4565</issn><publisher><publisher-name>LTD "Silicea-Poligraf"</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.15829/3034-4123-2025-70</article-id><article-id custom-type="edn" pub-id-type="custom">XDMEKA</article-id><article-id custom-type="elpub" pub-id-type="custom">prmed-70</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>РАЗВИТИЕ МЕТОДОВ ДИАГНОСТИКИ И ЛЕЧЕНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>DEVELOPMENT OF DIAGNOSTIC AND TREATMENT METHODS</subject></subj-group></article-categories><title-group><article-title>Старческая астения у пациентов с артериальной гипертензией и сердечной недостаточностью: клинико-анамнестические особенности</article-title><trans-title-group xml:lang="en"><trans-title>Frailty in patients with hypertension and heart failure: clinical and anamnestic features</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6965-5019</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сафроненко</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Safronenko</surname><given-names>V. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>К.м.н., доцент, доцент кафедры внутренних болезней № 1.</p><p>переулок Нахичеванский, д. 29, Ростов-на-Дону, 344022</p></bio><bio xml:lang="en"><p>Viktoria A. Safronenko.</p><p>Nakhichevansky Lane, 29, Rostov-on-Don, 344022</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9323-592X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Чесникова</surname><given-names>А. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Chesnikova</surname><given-names>A. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Д.м.н., профессор, зав. кафедрой внутренних болезней № 1.</p><p>переулок Нахичеванский, д. 29, Ростов-на-Дону, 344022</p></bio><bio xml:lang="en"><p>Anna I. Chesnikova.</p><p>Nakhichevansky Lane, 29, Rostov-on-Don, 344022</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5034-8625</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Скаржинская</surname><given-names>Н. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Skarzhinskaya</surname><given-names>N. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Скаржинская Наталья Сергеевна — к.м.н., доцент кафедры внутренних болезней № 1.</p><p>переулок Нахичеванский, д. 29, Ростов-на-Дону, 344022</p></bio><bio xml:lang="en"><p>Natalia S. Skarzhinskaya.</p><p>Nakhichevansky Lane, 29, Rostov-on-Don, 344022</p></bio><email xlink:type="simple">tasha84@list.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0005-3283-5330</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гридасова</surname><given-names>Р. A.</given-names></name><name name-style="western" xml:lang="en"><surname>Gridasova</surname><given-names>R. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Д.м.н., доцент кафедры внутренних болезней № 1.</p><p>переулок Нахичеванский, д. 29, Ростов-на-Дону, 344022</p></bio><bio xml:lang="en"><p>Rita A. Gridasova.</p><p>Nakhichevansky Lane, 29, Rostov-on-Don, 344022</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВО "Ростовский государственный медицинский университет" Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Rostov State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>23</day><month>01</month><year>2026</year></pub-date><volume>2</volume><issue>4</issue><fpage>17</fpage><lpage>27</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Сафроненко В.А., Чесникова А.И., Скаржинская Н.С., Гридасова Р.A., 2026</copyright-statement><copyright-year>2026</copyright-year><copyright-holder xml:lang="ru">Сафроненко В.А., Чесникова А.И., Скаржинская Н.С., Гридасова Р.A.</copyright-holder><copyright-holder xml:lang="en">Safronenko V.A., Chesnikova A.I., Skarzhinskaya N.S., Gridasova R.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://prmed.elpub.ru/jour/article/view/70">https://prmed.elpub.ru/jour/article/view/70</self-uri><abstract><sec><title>Цель</title><p>Цель. Оценить особенности факторов риска (ФР), структуры коморбидной патологии и клинической картины у пациентов в возрасте ≥80 лет с артериальной гипертензией (АГ) и хронической сердечной недостаточностью (ХСН) при наличии синдрома старческой астении (ССА).</p></sec><sec><title>Материал и методы</title><p>Материал и методы. Для проведения исследования пациенты с АГ и ХСН (n=161) были разделены на две группы в зависимости от наличия ССА: 1 группа — 84 пациента с АГ, ХСН и ССА, 2 группа — 77 пациентов с АГ, ХСН без ССА. Всем участникам проводилась оценка ФР, сопутствующей патологии, клинической симптоматики, когнитивного статуса по шкале MMSE, а также определение наличия ССА с помощью опросника "Возраст не помеха" и суточное мониторирование артериального давления (АД).</p></sec><sec><title>Результаты</title><p>Результаты. В 1 группе значимо чаще встречались хроническая болезнь почек (р&lt;0,001), фибрилляция предсердий (p&lt;0,001), более низкий индекс массы тела (p=0,029), деменция легкой (р=0,031) и умеренной (р&lt;0,001) степени тяжести; более низкие значения систолического АД в ночное время (р=0,026) и диастолического АД за день и ночь (р &lt;0,001 и р &lt;0,001, соответственно), более высокие значения вариабельности систолического АД за сутки и ночь (р=0,004 и р &lt;0,001, соответственно) по сравнению со 2 группой.</p></sec><sec><title>Заключение</title><p>Заключение. Выявление ССА на амбулаторном этапе — это ключевой элемент профилактической медицины и залог сохранения качества жизни пожилого человека.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Aim</title><p>Aim. To evaluate the characteristics of risk factors (RFs), the structure of comorbidities, and the clinical performance in patients aged ≥80 years with hypertension (HTN) and heart failure (HF) associated with frailty syndrome.</p></sec><sec><title>Material and methods</title><p>Material and methods. Patients with HTN and HF (n=161) were divided into two following groups based on frailty syndrome: group 1 — 84 patients with HTN, HF, and frailty; group 2 — 77 patients with HTN and HF without frailty. All participants underwent assessment of risk factors, comorbidities, symptoms, and cognitive status using the mini-mental state examination (MMSE). All participants were assessed for frailty syndrome using the Age Is Not a Barrier questionnaire and 24-hour blood pressure (BP) monitoring.</p></sec><sec><title>Results</title><p>Results. In group 1, there was a significantly higher incidence of chronic kidney disease (p&lt;0,001), atrial fibrillation (p&lt;0,001), lower body mass index (p=0,029), mild (p=0,031) and moderate (p&lt;0,001) dementia, as well as lower night-time systolic blood pressure (BP) (p=0,026) and daytime and nighttime diastolic BP (p&lt;0,001 and p&lt;0,001, respectively), higher 24-hour and nighttime systolic BP variability (p=0,004 and p&lt;0,001, respectively) compared to group 2.</p></sec><sec><title>Conclusion</title><p>Conclusion. Outpatient diagnosis of frailty is a main element of preventive medicine and the key to maintaining the quality of life of the elderly.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>синдром старческой астении</kwd><kwd>возраст ≥80 лет</kwd><kwd>артериальная гипертензия</kwd><kwd>хроническая сердечная недостаточность</kwd></kwd-group><kwd-group xml:lang="en"><kwd>frailty syndrome</kwd><kwd>age ≥80 years</kwd><kwd>hypertension</kwd><kwd>heart failure</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Collard RM. Prevalence of frailty in community dwelling older persons: a sys­te­ma­tic review. J Am Geriatr Soc. 2012;60(8):1487-92. doi:10.1111/j.1532-5415.2012.04054.x.</mixed-citation><mixed-citation xml:lang="en">Collard RM. Prevalence of frailty in community dwelling older persons: a sys­te­ma­tic review. J Am Geriatr Soc. 2012;60(8):1487-92. doi:10.1111/j.1532-5415.2012.04054.x.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Kojima G. Prevalence of frailty in nursing homes: A systematic review and metaanalysis. J Am Med Dir Assoc. 2015;16:940-5. doi:10.1016/j.jamda.2015.06.025.</mixed-citation><mixed-citation xml:lang="en">Kojima G. Prevalence of frailty in nursing homes: A systematic review and metaanalysis. J Am Med Dir Assoc. 2015;16:940-5. doi:10.1016/j.jamda.2015.06.025.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Villacampa-­Fernandez P, Navarro-­Pardo E, Tarin JJ, et al. Frailty and multi­mor­bidity: Two related yet different concepts. Maturitas. 2017;95:31-5. doi:10.1016/j.maturitas.2016.10.008.</mixed-citation><mixed-citation xml:lang="en">Villacampa-­Fernandez P, Navarro-­Pardo E, Tarin JJ, et al. Frailty and multi­mor­bidity: Two related yet different concepts. Maturitas. 2017;95:31-5. doi:10.1016/j.maturitas.2016.10.008.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Veronese N, Cereda E, Stubbs B, et al. Risk of cardiovascular disease morbidity and mortality in frail and prefrail older adults: Results from a meta-analysis and ex­plo­ratory meta-regression analysis. Ageing Res Rev. 2017;35:63-73. doi:10.1016/j.arr.2017.01.003.</mixed-citation><mixed-citation xml:lang="en">Veronese N, Cereda E, Stubbs B, et al. Risk of cardiovascular disease morbidity and mortality in frail and prefrail older adults: Results from a meta-analysis and ex­plo­ratory meta-regression analysis. Ageing Res Rev. 2017;35:63-73. doi:10.1016/j.arr.2017.01.003.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Ricci NA, Pessoa GS, Ferriolli E, et al. Frailty and cardiovascular risk in community-­dwel­ling elderly: a population-­based study. Clin Interv Aging. 2014;9:1677-85. doi:10.2147/CIA.S68642.</mixed-citation><mixed-citation xml:lang="en">Ricci NA, Pessoa GS, Ferriolli E, et al. Frailty and cardiovascular risk in community-­dwel­ling elderly: a population-­based study. Clin Interv Aging. 2014;9:1677-85. doi:10.2147/CIA.S68642.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Wang X, Zhou C, Li Y, et al. Prognostic Value of Frailty for Older Patients with Heart Failure: A Systematic Review and Meta-­Analysis of Prospective Studies. Bio­med Res Int. 2018; 2018:8739058. doi:10.1155/2018/8739058.</mixed-citation><mixed-citation xml:lang="en">Wang X, Zhou C, Li Y, et al. Prognostic Value of Frailty for Older Patients with Heart Failure: A Systematic Review and Meta-­Analysis of Prospective Studies. Bio­med Res Int. 2018; 2018:8739058. doi:10.1155/2018/8739058.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Ткачева О. Н., Котовская Ю. В., Рунихина Н. К. и др. Клинические рекомендации "Старческая астения". Российский журнал гериатрической медицины. 2020;(1):11-46. doi:10.37586/2686-8636-1-2020-11-46.</mixed-citation><mixed-citation xml:lang="en">Tkacheva ON, Kotovskaya YV, Runikhina NK, et al. Clinical guidelines on frailty. Rus­sian Journal of Geriatric Medicine. 2020;(1):11-46. (In Russ.) doi:10.37586/2686-8636-1-2020-11-46.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Ткачева О. Н., Котов­ская Ю. В., Ру­ни­хина Н. К. и др. Артериальная гипертония и антигипертензивная терапия у пациентов старших возрастных групп. Согласованное мнение экспертов Российской ассоциации геронтологов и гериатров, Анти­гипер­тензивной Лиги, Национального общества профилактической кардиологии. Рациональная Фар­макотерапия в Кардиологии 2021;17(4):642-61. doi:10.20996/1819-6446-2021-07-01.</mixed-citation><mixed-citation xml:lang="en">Tkacheva ON, Kotovskaya YuV, Runikhina NK, et al. Arterial hypertension and antihypertensive therapy in older patients. The agreed opinion of experts from the Russian Association of Gerontologists and Geriatricians, the Anti­hy­per­ten­sive League, the National Society for Preventive Cardiology. Rational Phar­ma­co­the­rapy in Cardiology 2021;17(4):642-61. (In Russ.) doi:10.20996/1819-6446-2021-07-01.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Терещенко С. Н., Галявич А. С., Ускач Т. М. и др. Хроническая сердечная недостаточность. Клинические рекомендации. 2020. Российский кардиологический журнал. 2020;25(11):4083. doi:10.15829/29/1560-4071-2020-4083.</mixed-citation><mixed-citation xml:lang="en">Tereshchenko SN, Galyavich AS, Uskach TM, et al. Clinical practice guidelines for Chro­nic heart failure 2020. Russian Journal of Cardiology. 2020;25(11):4083 (In Russ.) doi:10.15829/29/1560-4071-2020-4083.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Мареев В. Ю., Фо­мин И. В., Агеев Ф. Т. и др. Клинические рекомендации. Хроническая сердечная недостаточность (ХСН). Журнал Сердечная Недостаточность. 2017;18 (1):3-40. doi:10.18087/RHFJ.2017.1.2346.</mixed-citation><mixed-citation xml:lang="en">Mareev VYu, Fomin IV, Ageev FT, et al. Clinical guidelines. Chronic heart failure (CHF). Russian Heart Failure Journal. 2017;18 (1):3-40. (In Russ.) doi:10.18087/RHFJ.2017.1.2346.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Кобалава Ж. Д., Конради А. О., Недогода С. В., и др. Артериальная гипертензия у взрослых. Клинические рекомендации 2024. Российский кардиологический журнал. 2024;29(9):6117. doi:10.15829/1560-4071-2024-6117.</mixed-citation><mixed-citation xml:lang="en">Kobalava ZhD, Konradi AO, Nedogoda SV, et al. Clinical practice guidelines for Hypertension in adults. Russian Journal of Cardiology. 2024;29(9):6117. (In Russ.) doi:10.15829/1560-4071-2024-6117.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Гапон Л. И. Ар­те­ри­альная гипертония и жесткость артериальной стенки в клинической практике: обзор литературы. Российский кардиологический журнал. 2024;29(5): 5924. doi:10.15829/1560-4071-2024-5924. EDN VPKVJT.</mixed-citation><mixed-citation xml:lang="en">Gapon LI. Hypertension and arterial wall stiffness in clinical practice: literature re­view. Russian Journal of Cardiology. 2024;29(5):5924. (In Russ.) doi:10.15829/1560-4071-2024-5924. EDN VPKVJT.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Александрова Е. Б., Шиндина Т. С., Мак­симов М. Л. Хроническая сердечная недостаточность у больных гипертонической и ишемической болезнью сердца: возрастные и гендерные особенности. Врач скорой помощи. 2020;6:63-70. doi:10.33920/med-02-2006-07.</mixed-citation><mixed-citation xml:lang="en">Aleksandrova EB, Shindina TS, Maksimov ML. Chronic heart failure in patients with arterial hypertension and ischemic heart disease: age and gender specifics. Vrach skoroj pomoschi. 2020;6:63-70. (In Russ.) doi:10.33920/med-02-2006-07.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Комаров А. Л. Выбор лечебной тактики при тромбоэмболии легочной артерии средневысокого риска и хронической болезни почек. Кардиология. 2019;59(2):88-96. doi:10.18087/cardio.2019.2.10232.</mixed-citation><mixed-citation xml:lang="en">Komarov AL. The Choice of Treatment Tactics for Thromboembolism of the Pul­mo­nary Artery of Medium-­High Risk and Chronic Kidney Disease. Kardiologiia. 2019;59(2):88-96. (In Russ.) doi:10.18087/cardio.2019.2.10232.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Pulignano G, Del Sindaco D, Tinti MD, et al. IMAGE-HF Study Investigators. At­rial fibrillation, cognitive impairment, frailty and disability in older heart failure patients. J Cardiovasc Med (Hagerstown). 2016;17(8):616-23. doi:10.2459/JCM.0000000000000366.</mixed-citation><mixed-citation xml:lang="en">Pulignano G, Del Sindaco D, Tinti MD, et al. IMAGE-HF Study Investigators. At­rial fibrillation, cognitive impairment, frailty and disability in older heart failure patients. J Cardiovasc Med (Hagerstown). 2016;17(8):616-23. doi:10.2459/JCM.0000000000000366.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Sun-­Wook K, Sol-­Ji Y, Jung-­Yeon C, et al. Os 27-05 Frailty Assessment in Older Atrial Fibrillation Patients. J Hypertens. 2016;34:250. doi:10.1097/01.hjh.0000500565.02543.4e.</mixed-citation><mixed-citation xml:lang="en">Sun-­Wook K, Sol-­Ji Y, Jung-­Yeon C, et al. Os 27-05 Frailty Assessment in Older Atrial Fibrillation Patients. J Hypertens. 2016;34:250. doi:10.1097/01.hjh.0000500565.02543.4e.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Kim S, Yoon S, Choi J, et al. Clinical implication of frailty assessment in older pa­tients with atrial fibrillation. Arch Gerontol Geriatr. 2017;70:1-7. doi:10.1016/j.archger.2016.12.001.</mixed-citation><mixed-citation xml:lang="en">Kim S, Yoon S, Choi J, et al. Clinical implication of frailty assessment in older pa­tients with atrial fibrillation. Arch Gerontol Geriatr. 2017;70:1-7. doi:10.1016/j.archger.2016.12.001.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Wilkinson C, Todd O, Clegg A, et al. Management of atrial fibrillation for older people with frailty: a systematic review and meta-analysis. Age Ageing. 2019; 48(2):196-203. doi:10.1093/ageing/afy180.</mixed-citation><mixed-citation xml:lang="en">Wilkinson C, Todd O, Clegg A, et al. Management of atrial fibrillation for older people with frailty: a systematic review and meta-analysis. Age Ageing. 2019; 48(2):196-203. doi:10.1093/ageing/afy180.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Bo M, Li Puma F, Badinella Martini M, et al. Effects of oral anticoagulant the­rapy in older medical in-patients with atrial fibrillation: a prospective cohort obser­va­tional study. Aging Clin Exp Res. 2017;29(3):491-7. doi:10.1007/s40520-016-0569-7.</mixed-citation><mixed-citation xml:lang="en">Bo M, Li Puma F, Badinella Martini M, et al. Effects of oral anticoagulant the­rapy in older medical in-patients with atrial fibrillation: a prospective cohort obser­va­tional study. Aging Clin Exp Res. 2017;29(3):491-7. doi:10.1007/s40520-016-0569-7.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Руденко Т. Е., Бобкова И. Н., Камышова Е. С. и др. Старческая астения и хроническая болезнь почек — реальная проблема современной нефрологии. Терапевтический архив. 2023;95(6):516-20. doi:10.26442/00403660.2023.06.202270.</mixed-citation><mixed-citation xml:lang="en">Rudenko TE, Bobkova IN, Kamyshova ES, et al. Senile asthenia and chronic kid­ney disease are a real problem of modern nephrology. Therapeutic archive. 2023;95(6):516-20. (In Russ.) doi:10.26442/00403660.2023.06.202270.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Gandolfini I, Regolisti G, Bazzocchi A, et al. Frailty and Sarcopenia in Older Pa­tients Receiving Kidney Transplantation. Front Nutr. 2019;6:169. doi:10.3389/fnut.2019.00169.</mixed-citation><mixed-citation xml:lang="en">Gandolfini I, Regolisti G, Bazzocchi A, et al. Frailty and Sarcopenia in Older Pa­tients Receiving Kidney Transplantation. Front Nutr. 2019;6:169. doi:10.3389/fnut.2019.00169.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Драпкина О. М., Шепель Р. Н. Хро­ническая сердечная недостаточность и "парадокс ожирения". Журнал Сер­дечная Недостаточность. 2016;17(6):398-404. doi:10.18087/rhfj.2016.6.2263.</mixed-citation><mixed-citation xml:lang="en">Drapkina OM, Shepel RN. Chronic heart failure and the "obesity paradox". Journal of Heart Failure. 2016;17(6):398-404. (In Russ.) doi:10.18087/rhfj.2016.6.2263.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Сафроненко В. А., Чесникова А. И. Оценка уровня NT-proBNP у пациентов с артериальной гипертензией в возрасте 80 лет и старше в зависимости от наличия сердечной недостаточности и синдрома старческой астении. Архивъ внутренней медицины. 2024;14(5): 352-60. doi:10.20514/2226-6704-2024-14-5-352-360. EDN: JUDFQA.</mixed-citation><mixed-citation xml:lang="en">Safronenko VA, Chesnikova AI. Assessment of the Level of NT-proBNP in Patients with Arterial Hypertension Aged 80 Years and Older, Depending on the Presence of Heart Failure and Senile Asthenia Syndrome. The Russian Archives of Internal Medicine. 2024;14(5):352-60. (In Russ.) doi:10.20514/2226-6704-2024-14-5-352-360. EDN: JUDFQA.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Diehr P, Williamson J, Burke GL, et al. The aging and dying processes and the health of older adults. J Clin Epidemiol. 2002;55(3):269-78. doi:10.1016/s0895-4356(01)00462-0.</mixed-citation><mixed-citation xml:lang="en">Diehr P, Williamson J, Burke GL, et al. The aging and dying processes and the health of older adults. J Clin Epidemiol. 2002;55(3):269-78. doi:10.1016/s0895-4356(01)00462-0.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Van Bemmel T, Holman ER, Gussekloo J, et al. Low blood pressure in the very old, a consequence of imminent heart failure: The Leiden 85-plus Study. J Hum Hypertens. 2009;23(1):27-32. doi:10.1038/jhh.2008.79.</mixed-citation><mixed-citation xml:lang="en">Van Bemmel T, Holman ER, Gussekloo J, et al. Low blood pressure in the very old, a consequence of imminent heart failure: The Leiden 85-plus Study. J Hum Hypertens. 2009;23(1):27-32. doi:10.1038/jhh.2008.79.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Gijon-­Conde T, Graciani A, Lopez-­García E, et al. Frailty, disability and ambulatory blood pressure in older adults. J Am Med Dir Assoc. 2018;19(5):433-8. doi:10.1016/j.jamda.2017.11.014.</mixed-citation><mixed-citation xml:lang="en">Gijon-­Conde T, Graciani A, Lopez-­García E, et al. Frailty, disability and ambulatory blood pressure in older adults. J Am Med Dir Assoc. 2018;19(5):433-8. doi:10.1016/j.jamda.2017.11.014.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
