Management of patients with iron deficiency anemia in the context of primary health care. Guidelines

Iron deficiency anemia is a multietiological disease, the development of which is associated with iron deficiency due to its impaired intake, absorption or increased losses, characterized by microcytosis and hypochromic anemia. The practical guide describes in detail the etiology, paraclinical diagnostics, management of patients in various clinical situations. Guidelines are intended for primary health care professionals, including internists, general practitioners, cardiologists, gastroenterologists and other specialists providing care to patients with iron deficiency anemia.

1. Diagnosis and treatment of iron deficiency anemia in children: A manual for doctors. Edited by akad. RAS Prof. Rumyantseva A.G. and Prof. Zakharova I.N. KONTI PRINT LLC, 2015. 76 p. (In Russ.)

2. Healthcare in Russia. Moscow: Rosstat; 2023. 180 p. (In Russ.)

3. Dikke GB, Stuklov NI. Algorithms for the diagnosis and treatment of iron deficiency anemia and latent iron deficiency in women of reproductive age. The consensus of an obstetrician-gynecologist and a hematologist. Obstetrics and gynecology. 2020;9:22-6. (In Russ.)

4. Kotova EG, Kobyakova OS, Starodubov VI, et al. Morbidity of the entire Russian population in 2020: statistical materials. Central Research Institute of the Ministry of Health of Russia; 2021. 146 p. (In Russ.) ISBN: 978-5-94116-039-6, EDN: VMTKHO.

5. Volkova SA, Mayansky NA, Borovkov NN, et al. Hemogram indicators in the adult working population. Hematology and transfusiology. 2008;53(1):21-7. (In Russ.)

6. Drapkina OM, Martynov AI, Baida AP, et al. Resolution of the expert council "Relevant issues of iron deficiency in the Russian Federation". Cardiovascular Therapy and Prevention. 2020;19(5):2700. (In Russ.) doi:10.15829/1728-8800-2020-2700.

7. Rukavitsyn OA. A short guide for practitioners of all specialties. GEOTAR-Media; 2021. 352 p. (In Russ.) Рукавицын О.А. Краткое руководство для практических врачей всех специальностей. ГЭОТАР-Медиа; 2021. 352 с. ISBN: 978-5-9704-8188-2.

8. Mansour D, Hofmann A, Gemzell-Danielsson K. A Review of Clinical Guidelines on the Management of Iron Deficiency and Iron-Deficiency Anemia in Women with Heavy Menstrual Bleeding. Adv Ther. 2021;38(1):201-25. doi:10.1007/s12325-020-01564-y.

9. Batchelor EK, Kapitsinou P, Pergola PE, et al. Iron Deficiency in Chronic Kidney Disease: Updates on Pathophysiology, Diagnosis, and Treatment. JASN. 2020;31(3): 456-68. doi:10.1681/ASN.2019020213.

10. De Franceschi L, Iolascon A, Taher A, Cappellini MD. Clinical management of iron deficiency anemia in adults: Systemic review on advances in diagnosis and treatment. European Journal of Internal Medicine. 2017;42:16-23. doi:10.1016/j.ejim.2017.04.018.

11. Camaschella C.Iron deficiency. Blood. 2019;133(1):30-9. doi:10.1182/blood-2018-05-815944.

12. Cappellini MD, Musallam KM, Taher AT. Iron deficiency anaemia revisited. J Intern Med. 2020;287(2):153-70. doi:10.1111/joim.13004.

13. Lopez A, Cacoub P, Macdougall IC, Peyrin-Biroulet L. Iron deficiency anaemia. The Lancet. 2016;387(10021):907-16. doi:10.1016/S0140-6736(15)60865-0.

14. Mirza FG, Abdul-Kadir R, Breymann C, Fraser IS, Taher A. Impact and management of iron deficiency and iron deficiency anemia in women’s health. Expert Review of Hematology. 2018;11(9):727-36. doi:10.1080/17474086.2018.1502081.

15. Cotter J, Baldaia C, Ferreira M, et al. Diagnosis and treatment of iron-deficiency anemia in gastrointestinal bleeding: A systematic review. WJG. 2020;26(45):7242- 57. doi:10.3748/wjg.v26.i45.7242.

16. Breymann C, Honegger C, Hösli I, Surbek D. Diagnosis and treatment of irondeficiency anaemia in pregnancy and postpartum. Arch Gynecol Obstet. 2017;296(6): 1229-34. doi:10.1007/s00404-017-4526-2.

17. Peyrin-Biroulet L, Williet N, Cacoub P. Guidelines on the diagnosis and treatment of iron deficiency across indications: a systematic review. The American Journal of Clinical Nutrition. 2015;102(6):1585-94. doi:10.3945/ajcn.114.103366.

18. Numan S, Kaluza K. Systematic review of guidelines for the diagnosis and treatment of iron deficiency anemia using intravenous iron across multiple indications. Current Medical Research and Opinion. 2020;36(11):1769-82. doi:10.1080/03007995.2020.1824898.

19. Alekseeva OP. Modern principles of diagnosis and treatment of iron deficiency anemia and iron deficiency in gastroenterological diseases: a review of current clinical recommendations. Remedium. 2021;(2):70-6. (In Russ.) doi:10.21518/1561-5936-2021-2-70-76.

20. Bakulin IG, Oganezova IA, Bakulina NV. Outpatient gastroenterology: a guide for doctors. 2020. 300 p. (In Russ.) ISBN: 978-5-6047195-6-5.

21. Aisen P. Chemistry and biology of eukaryotic iron metabolism. The International Journal of Biochemistry & Cell Biology. 2001;33(10):940-959. doi:10.1016/S1357-2725(01)00063-2.

22. Abbaspour N, Hurrell R, Kelishadi R. Review on iron and its importance for human health. J Res Med Sci. 2014;19(2):164-74.

23. Puig S, Ramos-Alonso L, Romero AM, Martínez-Pastor MT. The elemental role of iron in DNA synthesis and repair. Metallomics. 2017;9(11):1483-500. doi:10.1039/C7MT00116A.

24. Rockfield S, Chhabra R, Robertson M, et al. Links Between Iron and Lipids: Implications in Some Major Human Diseases. Pharmaceuticals. 2018;11(4):113. doi:10.3390/ph11040113.

25. Mole DR. Iron Homeostasis and Its Interaction with Prolyl Hydroxylases. Antioxidants & Redox Signaling. 2010;12(4):445-58. doi:10.1089/ars.2009.2790.

26. Ramsay AJ, Hooper JD, Folgueras AR, et al. Matriptase-2 (TMPRSS6): a proteolytic regulator of iron homeostasis. Haematologica. 2009;94(6):840-9. doi:10.3324/haematol.2008.001867.

27. Istiqomah N, Umarghanies SS, Farmawati A, et al. Polimorfisme gen ferroportin (FPN1) -1355 G/C sebagai faktor risiko anemia defisiensi besi pada ibu hamil. Jurnal Gizi Klinik Indonesia. 2013;9(4):162. doi:10.22146/ijcn.18364.

28. Azman NA, Zulkafli Z, Bakar NS, Assyuhada MGSN, Mohammad SNNA. Association of single nucleotide polymorphism at BMP2 gene with iron deficiency status among anaemic patients in Hospital Universiti Sains Malaysia. Egypt J Med Hum Genet. 2024;25(1):46. doi:10.1186/s43042-024-00511-8.

29. Bakirova AE, Partsernyak AS, Kudlay DA, et al. Molecular and genetic features of iron deficiency anemia phenotypes. Molecular medicine. 2025;23(3):56-61. (In Russ.)

30. Finberg KE, Heeney MM, Campagna DR, et al. Mutations in TMPRSS6 cause ironrefractory iron deficiency anemia (IRIDA). Nat Genet. 2008;40(5):569-571. doi:10.1038/ng.130.

31. Milet J, Le Gac G, Scotet V, et al. A common SNP near BMP2 is associated with severity of the iron burden in HFE p.C282Y homozygous patients: A followup study. Blood Cells, Molecules, and Diseases. 2010;44(1):34-7. doi:10.1016/j.bcmd.2009.10.001.

32. Bösch ES, Spörri J, Scherr J. Genetic Variants Affecting Iron Metabolism in Healthy Adults: A Systematic Review to Support Personalized Nutrition Strategies. Nutrients. 2024;16(22):3793. doi:10.3390/nu16223793.

33. Nalado AM, Dickens C, Dix-Peek T, et al. TMPRSS6 rs855791 polymorphism and susceptibility to iron deficiency anaemia in non-dialysis chronic kidney disease patients in South Africa. Int J Mol Epidemiol Genet. 2019;10(1):1-9.

34. Al-Amer O, Hawasawi Y, Oyouni AAA, et al. Study the association of transmembrane serine protease 6 gene polymorphisms with iron deficiency status in Saudi Arabia. Gene. 2020;751:144767. doi:10.1016/j.gene.2020.144767.

35. Elmahdy M, Elhakeem H, Gaber F, Mourad F. TMPRSS6 Gene Polymorphism and Serum Hepcidin in Iron Deficiency Anemia. The Egyptian Journal of Hospital Medicine. 2018;73(7):7090-103. doi:10.21608/ejhm.2018.17507.

36. Pellegrino RM, Coutinho M, D’Ascola D, et al. Two novel mutations in the tmprss6 gene associated with iron-refractory iron-deficiency anaemia (irida) and partial expression in the heterozygous form. Br J Haematol. 2012;158(5):668-72. doi:10.1111/j.1365-2141.2012.09198.x.

37. Kodentsova VM. Vitamins. (2nd ed., revised, ed.). Moscow: Publishing House Medical Information Agency, LLC; 2023. 528 p. (In Russ.) ISBN: 978-5-9986-0517-8.

38. Bermejo F, García-López S. A guide to diagnosis of iron deficiency and iron deficiency anemia in digestive diseases. WJG. 2009;15(37):4638. doi:10.3748/wjg.15.4638.

39. Means RJ, Krantz S. Progress in understanding the pathogenesis of the anemia of chronic disease. Blood. 1992;80(7):1639-47. doi:10.1182/blood.V80.7.1639.bloodjournal8071639.

40. Idelson LI, Vorobyev PA. Handbook of Hematology. Volume 3. M: Newdiamed; 2005. 416 p. (In Russ.) ISBN: 5-88107-054-2.

41. Lukina EA, Dezhenkova AV. Iron metabolism in normal and pathological conditions. Clinical oncohematology. 2015;8(4):355-61. (In Russ.)

42. Ems T, Lucia K, Huecker MR. Biochemistry, Iron Absorption. StatPearls Publishing; 2021.

43. Camaschella C.New insights into iron deficiency and iron deficiency anemia. Blood Reviews. 2017;31(4):225-33. doi:10.1016/j.blre.2017.02.004.

44. Wallace DF. The Regulation of Iron Absorption and Homeostasis. Clin Biochem Rev. 2016;37(2):51-62.

45. Guo S, Huang J, Jiang H, et al. Restless Legs Syndrome: From Pathophysiology to Clinical Diagnosis and Management. Front Aging Neurosci. 2017;9:171. doi:10.3389/fnagi.2017.00171.

46. Hoes MF, Grote Beverborg N, Kijlstra JD, et al. Iron deficiency impairs contractility of human cardiomyocytes through decreased mitochondrial function. European J of Heart Fail. 2018;20(5):910-9. doi:10.1002/ejhf.1154.

47. Martens P, Dupont M, Mullens W. Cardiac iron deficiency — how to refuel the engine out of fuel. European J of Heart Fail. 2018;20(5):920-2. doi:10.1002/ejhf.1174.

48. Vorobyov AI. Rational pharmacotherapy of diseases of the blood system. Moscow: Litterra, 2009. 688 p. (In Russ.) ISBN: 978-5-904090-05-0.

49. Wander K, Shell-Duncan B, McDade TW. Evaluation of iron deficiency as a nutritional adaptation to infectious disease: An evolutionary medicine perspective. American J Hum Biol. 2009;21(2):172-9. doi:10.1002/ajhb.20839.

50. Soppi E.Iron Deficiency Without Anemia — Common, Important, Neglected. Clin Case Rep Rev. 2019;5(2). doi:10.15761/CCRR.1000456.

51. Lugovskaya SA, Pochtar ME, Dolgov VV. Hematological analyzers. Interpretation of the blood test. Moscow: OOO "Publishing House Triada", 2007. 112 p. (In Russ.) ISBN: 978- 5-94789-234-5.

52. Dolgov VV, Lugovskaya SA, Morozova VT, Pochtar ME. Laboratory diagnostics of anemia. 2nd ed., supplement M.: Tver: Triad, 2009. 148 p. (In Russ.) ISBN: 978-5-94789-340-3.

53. Dolgov VV, Lugovskaya SA, Pochtar ME, Fedorova MM. Laboratory diagnostics of iron metabolism disorders (textbook). Triad; 2014. 72 p. (In Russ.) ISBN: 978-5- 94789-621-3.

54. Auerbach M, Adamson JW. How we diagnose and treat iron deficiency anemia. Am J Hematol. 2016;91(1):31-8. doi:10.1002/ajh.24201.

55. Thumbe A, Quraishi MN, Dabhi K, et al. PTU-060 Iron deficiency anaemia in plain sight at the front door in the midlands. In: Posters. BMJ Publishing Group Ltd and British Society of Gastroenterology; 2019:A147.1-A147. doi:10.1136/gutjnl-2019-BSGAbstracts.276.

56. Dvoretsky LI. Anemia: strategy and tactics of diagnostic search. Polyclinic doctor's Handbook. 2002;(6):5-10. (In Russ.)

57. ASGE Standards of Practice Committee, Gurudu SR, Bruining DH, et al. The role of endoscopy in the management of suspected small-bowel bleeding. Gastrointest Endosc. 2017;85(1):22-31. doi:10.1016/j.gie.2016.06.013.

58. Pennazio M, Eisen G, Goldfarb N. ICCE Consensus for Obscure Gastrointestinal Bleeding. Endoscopy. 2005;37(10):1046-50. doi:10.1055/s-2005-870319.

59. Snook J, Bhala N, Beales ILP, et al. British Society of Gastroenterology guidelines for the management of iron deficiency anaemia in adults. Gut. 2021;70(11):2030- 51. doi:10.1136/gutjnl-2021-325210.

60. Tarasova IS, Chernov VM, Lavrukhin DB, Rumyantsev AG. Assessment of sensitivity and specificity of symptoms of anemia and sideropenia. Hematology and transfusiology. 2011;56(5):6-13. (In Russ.)

61. Enns RA, Hookey L, Armstrong D, et al. Clinical Practice Guidelines for the Use of Video Capsule Endoscopy. Gastroenterology. 2017;152(3):497-514. doi:10.1053/j.gastro.2016.12.032.

62. Goddard AF, James MW, McIntyre AS, Scott BB, on behalf of the British Society of Gastroenterology. Guidelines for the management of iron deficiency anaemia. Gut. 2011;60(10):1309-16. doi:10.1136/gut.2010.228874.

63. Nayagam J, Ha S, Barreto L, Zang A, Curtis H. PTU-120 Iron deficiency anaemia in renal cell carcinoma. In: Gastroenterology Service. BMJ Publishing Group Ltd and British Society of Gastroenterology; 2018:A250.2-A252. doi:10.1136/gutjnl-2018-BSGAbstracts.498.

64. ASGE Standards of Practice Committee, Fisher L, Lee Krinsky M, et al. The role of endoscopy in the management of obscure GI bleeding. Gastrointest Endosc. 2010;72(3):471-9. doi:10.1016/j.gie.2010.04.032.

65. Pasricha SR, Tye-Din J, Muckenthaler MU, Swinkels DW. Iron deficiency. Lancet. 2021;397(10270):233-48. doi:10.1016/S0140-6736(20)32594-0.

66. Pennazio M, Spada C, Eliakim R, et al. Small-bowel capsule endoscopy and deviceassisted enteroscopy for diagnosis and treatment of small-bowel disorders: European Society of Gastrointestinal Endoscopy (ESGE) Clinical Guideline. Endoscopy. 2015;47(4):352-76. doi:10.1055/s-0034-1391855.

67. Wolthuis AM, Meuleman C, Tomassetti C, et al. Bowel endometriosis: colorectal surgeon’s perspective in a multidisciplinary surgical team. World J Gastroenterol. 2014;20(42):15616-23. doi:10.3748/wjg.v20.i42.15616.

68. Ivashkin VT, Mayev IV, Kaprin AD, et al. Early detection of oncological diseases of the digestive system (methodological guidelines of the Russian Gastroenterological Association and the Association of Oncologists of Russia for primary care physicians). Russian Journal of Gastroenterology, Hepatology, and Coloproctology. 2019;29(5):53-74. (In Russ) doi:10.22416/1382-4376-2019-29-5-53-74.

69. Ivanova EV, Fedorov ED, Tikhomirova EV, et al. Colonoscopy using a video capsule: possibilities of noninvasive diagnosis of colon diseases. Research and practice in medicine. 2017;4(1):13-22. (In Russ.) doi:10.17709/2409-2231-2017-4-1-2.

70. Spada C, McNamara D, Despott EJ, et al. Performance measures for small-bowel endoscopy: a European Society of Gastrointestinal Endoscopy (ESGE) Quality Improvement Initiative. Endoscopy. 2019;51(06):574-98. doi:10.1055/a-0889-9586.

71. 2021 exceptional surveillance of suspected cancer: recognition and referral (NICE guideline NG12) and suspected neurological conditions: recognition and referral (NICE guideline NG127) [Internet]. London: National Institute for Health and Care Excellence (NICE); 2021. ISBN-13: 978-1-4731-4277-0.

72. Kothari S, Afshar Y, Friedman LS, Ahn J. AGA Clinical Practice Update on Pregnancy-Related Gastrointestinal and Liver Disease: Expert Review. Gastroenterology. 2024;167(5):1033-45. doi:10.1053/j.gastro.2024.06.014.

73. Shergill AK, Ben-Menachem T, Chandrasekhara V, et al. Guidelines for endoscopy in pregnant and lactating women. Gastrointestinal Endoscopy. 2012;76(1):18-24. doi:10.1016/j.gie.2012.02.029.

74. Tran TT, Ahn J, Reau NS. ACG Clinical Guideline: Liver Disease and Pregnancy. American Journal of Gastroenterology. 2016;111(2):176-94. doi:10.1038/ajg.2015.430.

75. Savas N. Gastrointestinal endoscopy in pregnancy. WJG. 2014;20(41):15241. doi:10.3748/wjg.v20.i41.15241.

76. Koffas A, Laskaratos FM, Epstein O. Non-small bowel lesion detection at small bowel capsule endoscopy: A comprehensive literature review. World J Clin Cases. 2018;6(15):901-7. doi:10.12998/wjcc.v6.i15.901.

77. Weng TC, Chang CH, Dong YH, et al. Anaemia and related nutrient deficiencies after Roux-en-Y gastric bypass surgery: a systematic review and meta-analysis. BMJ Open. 2015;5(7):e006964. doi:10.1136/bmjopen-2014-006964.

78. Malfertheiner P, Megraud F, Rokkas T, et al. Management of Helicobacter pylori infection: the Maastricht VI/Florence consensus report. Gut. 2022;71(9):1724-62. doi:10.1136/gutjnl-2022-327745.

79. Tanous O, Levin C, Suchdev PS, et al. Resolution of iron deficiency following successful eradication of Helicobacter pylori in children. Acta Paediatrica. 2022;111(5):1075-82. doi:10.1111/apa.16255.

80. Annibale B, Marignani M, Monarca B, et al. Reversal of Iron Deficiency Anemia after Helicobacter pylori Eradication in Patients with Asymptomatic Gastritis. Ann Intern Med. 1999;131(9):668-72. doi:10.7326/0003-4819-131-9-199911020-00006.

81. Wenzhen Y, Yumin L, Kehu Y, et al. Iron deficiency anemia in Helicobacter pylori infection: meta-analysis of randomized controlled trials. Scandinavian Journal of Gastroenterology. 2010;45(6):665-76. doi:10.3109/00365521003663670.

82. Miernyk K, Bruden D, Zanis C, et al. The Effect of Helicobacter pylori Infection on Iron Stores and Iron Deficiency in Urban Alaska Native Adults. Helicobacter. 2013;18(3):222-8. doi:10.1111/hel.12036.

83. Rockey DC, Altayar O, Falck-Ytter Y, Kalmaz D. AGA Technical Review on Gastrointestinal Evaluation of Iron Deficiency Anemia. Gastroenterology. 2020;159(3):1097- 19. doi:10.1053/j.gastro.2020.06.045.

84. Lazebnik LB, Tkachenko EI, Oreshko LS, et al. Recommendations for the diagnosis and treatment of adult celiac disease. Experimental and clinical gastroenterology. 2015;5(117):3-12. (In Russ.)

85. He B, Yang J, Xiao J, et al. Accuracy of Computed Tomographic Enterography for Obscure Gastrointestinal Bleeding: A Diagnostic Meta-analysis. Acad Radiol. 2018;25(2):196-201. doi:10.1016/j.acra.2017.09.001.

86. Gunjan D, Sharma V, Rana SS, Bhasin DK. Small bowel bleeding: a comprehensive review. Gastroenterol Rep (Oxf). 2014;2(4):262-75. doi:10.1093/gastro/gou025.

87. Zhang BL, Jiang LL, Chen CX, Zhong BS, Li YM. Diagnosis of obscure gastrointestinal hemorrhage with capsule endoscopy in combination with multiple-detector computed tomography. J Gastroenterol Hepatol. 2010;25(1):75-9. doi:10.1111/j.1440-1746.2009.06016.x.

88. Huprich JE, Fletcher JG, Fidler JL, et al. Prospective blinded comparison of wireless capsule endoscopy and multiphase CT enterography in obscure gastrointestinal bleeding. Radiology. 2011;260(3):744-51. doi:10.1148/radiol.11110143.

89. Ivanova EV, Fedorov ED. Capsule and balloon-assisted enteroscopy in the diagnosis and treatment of diseases of the small intestine. Methodical manual.; 2014. 50 p. (In Russ.)

90. Rossi RE, Zullo A, Ferretti S, et al. Diagnostic Yield of Small Bowel Videocapsule Endoscopy in Patients with Iron Deficiency Anemia. A Systematic Review and metaanalysis. Journal of Clinical Gastroenterology. 2024;58(10):998-1002. doi:10.1097/MCG.0000000000001968.

91. Koulaouzidis A, Rondonotti E, Giannakou A, Plevris JN. Diagnostic yield of smallbowel capsule endoscopy in patients with iron-deficiency anemia: a systematic review. Gastrointestinal Endoscopy. 2012;76(5):983-92. doi:10.1016/j.gie.2012.07.035.

92. Muhammad A. Role of small bowel capsule endoscopy in the diagnosis and management of iron deficiency anemia in elderly: A comprehensive review of the current literature. WJG. 2014;20(26):8416. doi:10.3748/wjg.v20.i26.8416.

93. Ivanova EV, Fedorov ED, Yudin OI, et al. Diagnosis and treatment of intraluminal gastrointestinal bleeding with an unidentified source. Sechenovsky Bulletin. 2018;1(31):40-7. (In Russ.)

94. Tikhomirova EV, Ivanova EV, Budykina AV, et al. Clinical results of diagnosis and treatment of small intestine bleeding. Endoscopic surgery. 2023;(5):5-14. (In Russ.)

95. Robertson AR, Yung DE, Douglas S, Plevris JN, Koulaouzidis A. Repeat capsule endoscopy in suspected gastrointestinal bleeding. Scandinavian Journal of Gastroenterology. 2019;54(5):656-61. doi:10.1080/00365521.2019.1606932

96. Milman N.Prepartum anaemia: prevention and treatment. Ann Hematol. 2008; 87(12):949-59. doi:10.1007/s00277-008-0518-4.

97. Achebe MM, Gafter-Gvili A. How I treat anemia in pregnancy: iron, cobalamin, and folate. Blood. 2017;129(8):940-9. doi:10.1182/blood-2016-08-672246.

98. Bener A, Kamal M, Bener H, Bhugra D. Higher prevalence of iron deficiency as strong predictor of attention deficit hyperactivity disorder in children. Ann Med Health Sci Res. 2014;4(Suppl 3):S291-7. doi:10.4103/2141-9248.141974.

99. Lozoff B, Jimenez E, Smith JB. Double burden of iron deficiency in infancy and low socioeconomic status: a longitudinal analysis of cognitive test scores to age 19 years. Arch Pediatr Adolesc Med. 2006;160(11):1108-13. doi:10.1001/archpedi.160.11.1108.

100. McCann S, Perapoch Amadó M, Moore SE. The Role of Iron in Brain Development: A Systematic Review. Nutrients. 2020;12(7):2001. doi:10.3390/nu12072001.

101. Radlowski EC, Johnson RW. Perinatal iron deficiency and neurocognitive development. Front Hum Neurosci. 2013;7. doi:10.3389/fnhum.2013.00585.

102. Slomian J, Honvo G, Emonts P, Reginster JY, Bruyère O. Consequences of maternal postpartum depression: A systematic review of maternal and infant outcomes. Womens Health (Lond Engl). 2019;15:1745506519844044. doi:10.1177/1745506519844044.

103. Xu F, Roberts L, Binns C, Sullivan E, Homer CSE. Anaemia and depression before and after birth: a cohort study based on linked population data. BMC Psychiatry. 2018;18(1):224. doi:10.1186/s12888-018-1796-6.

104. Reveiz L, Gyte GM, Cuervo LG, Casasbuenas A. Treatments for iron-deficiency anaemia in pregnancy. Cochrane Database Syst Rev. 2011;(10):CD003094. doi:10.1002/14651858.CD003094.pub3.

105. Muñoz M, Peña-Rosas JP, Robinson S, et al. Patient blood management in obstetrics: management of anaemia and haematinic deficiencies in pregnancy and in the postpartum period: NATA consensus statement. Transfusion Medicine. 2018;28(1):22- 39. doi:10.1111/tme.12443.

106. Pavord S, Daru J, Prasannan N, et al. UK guidelines on the management of iron deficiency in pregnancy. Br J Haematol. 2020;188(6):819-30. doi:10.1111/bjh.16221.

107. Brown JC, Harhay MO, Harhay MN. The Prognostic Importance of Frailty in Cancer Survivors. J American Geriatrics Society. 2015;63(12):2538-43. doi:10.1111/jgs.13819.

108. Röhrig G, Gütgemann I, Leischker A, Kolb G. Anämie im Alter — ein geriatrisches Syndrom?: Zweites Positionspapier zur Anämie im Alter der AG Anämie der Deutschen Gesellschaft für Geriatrie. Z Gerontol Geriat. 2018;51(8):921-23. doi:10.1007/s00391-018-1457-x.

109. Katsumi A, Abe A, Tamura S, Matsushita T. Anemia in older adults as a geriatric syndrome: A review. Geriatrics Gerontology Int. 2021;21(7):549-54. doi:10.1111/ggi.14183.

110. QuickStats: Prevalence of Anemia Among Adults Aged ≥65 Years, by Sex and Age Group — National Health and Nutrition Examination Survey, 2013–2016. MMWR Morb Mortal Wkly Rep. 2018;67(42):1198. doi:10.15585/mmwr.mm6742a8.

111. Chueh HW, Jung HL, Shim YJ, Choi HS, Han JY. High anemia prevalence in Korean older adults, an advent healthcare problem: 2007–2016 KNHANES. BMC Geriatr. 2020;20(1):509. doi:10.1186/s12877-020-01918-9.

112. Eisenstaedt R, Penninx BWJH, Woodman RC. Anemia in the elderly: Current understanding and emerging concepts. Blood Reviews. 2006;20(4):213-26. doi:10.1016/j.blre.2005.12.002.

113. Beghé C, Wilson A, Ershler WB. Prevalence and outcomes of anemia in geriatrics: a systematic review of the literature. The American Journal of Medicine. 2004;116(7):3-10. doi:10.1016/j.amjmed.2003.12.009.

114. Bach V, Schruckmayer G, Sam I, et al. Prevalence and possible causes of anemia in the elderly: a cross-sectional analysis of a large European university hospital cohort. Clin Interv Aging. 2014;9:1187-96. doi:10.2147/CIA.S61125.

115. Jia W, Wang S, Liu M, et al. Anemia in centenarians: prevalence and association with kidney function. Hematology. 2020;25(1):26-33. doi:10.1080/16078454.2019.1703448.

116. Khovasova NO, Vorobyova NM, Tkacheva ON, et al. The prevalence of anemia and its associations with other geriatric syndromes in people over 65 years of age: data from the Russian epidemiological study EUCALYPTUS. Therapeutic Archive. 2022;94(1):24-31. (In Russ.) doi:10.26442/00403660.2022.01.201316.

117. Pires Corona L, Drumond Andrade FC, De Oliveira Duarte YA, Lebrao ML. The relationship between anemia, hemoglobin concentration and frailty in Brazilian older adults. The Journal of nutrition, health and aging. 2015;19(9):935-40. doi:10.1007/s12603-015-0502-3.

118. Ariza-Solé A, Lorente V, Formiga F, et al. Prognostic impact of anemia according to frailty status in elderly patients with acute coronary syndromes. Journal of Cardiovascular Medicine. 2020;21(1):27-33. doi:10.2459/JCM.0000000000000884.

119. Kim EY, Son YJ. Association between Anemia and Cognitive Impairment among Elderly Patients with Heart Failure. IJERPH. 2019;16(16):2933. doi:10.3390/ijerph16162933.

120. Hong CH, Falvey C, Harris TB, et al. Anemia and risk of dementia in older adults: Findings from the Health ABC study. Neurology. 2013;81(6):528-33. doi:10.1212/WNL.0b013e31829e701d.

121. Hidese S, Saito K, Asano S, Kunugi H. Association between iron-deficiency anemia and depression: A web-based Japanese investigation. Psychiatry Clin Neurosci. 2018;72(7):513-521. doi:10.1111/pcn.12656.

122. Wangping J, Ke H, Shengshu W, et al. Associations Between Anemia, Cognitive Impairment, and All-Cause Mortality in Oldest-Old Adults: A Prospective PopulationBased Cohort Study. Front Med. 2021;8:613426. doi:10.3389/fmed.2021.613426.

123. Santos PHS, Carmo ÉA, Carneiro JAO, et al. Handgrip strength: An effective screening instrument for anemia in the elderly women. Public Health Nursing. 2019;36(2):178-83. doi:10.1111/phn.12579.

124. Wouters HJCM, Van Der Klauw MM, De Witte T, et al. Association of anemia with health-related quality of life and survival: a large population-based cohort study. Haematologica. 2019;104(3):468-76. doi:10.3324/haematol.2018.195552.

125. Zilinski J, Zillmann R, Becker I, et al. Prevalence of anemia among elderly inpatients and its association with multidimensional loss of function. Ann Hematol. 2014;93(10):1645-54. doi:10.1007/s00277-014-2110-4.

126. Marzban M, Nabipour I, Farhadi A, et al. Association between anemia, physical performance and cognitive function in Iranian elderly people: evidence from Bushehr Elderly Health (BEH) program. BMC Geriatr. 2021;21(1):329. doi:10.1186/s12877-021-02285-9.

127. Khovasova NO, Naumov AV, Tkacheva ON. The effect of anemia on the geriatric status of an elderly person. Clinical gerontology. 2021;27(3-4):15-24. (In Russ.) doi:10.26347/1607-2499202103-04015-024.

128. Yoshimura Y, Wakabayashi H, Nagano F, et al. Low Hemoglobin Levels are Associated with Sarcopenia, Dysphagia, and Adverse Rehabilitation Outcomes After Stroke. Journal of Stroke and Cerebrovascular Diseases. 2020;29(12):105405. doi:10.1016/j.jstrokecerebrovasdis.2020.105405.

129. Bani Hassan E, Vogrin S, Hernandez Viña I, et al. Hemoglobin Levels are Low in Sarcopenic and Osteosarcopenic Older Persons. Calcif Tissue Int. 2020;107(2):135- 42. doi:10.1007/s00223-020-00706-2.

130. Penninx BWJH, Pluijm SMF, Lips P, et al. Late-Life Anemia Is Associated with Increased Risk of Recurrent Falls. J American Geriatrics Society. 2005;53(12):2106-11. doi:10.1111/j.1532-5415.2005.00491.x.

131. Teng Y, Teng Z, Xu S, et al. The Analysis for Anemia Increasing Fracture Risk. Med Sci Monit. 2020;26. doi:10.12659/MSM.925707.

132. Valderrábano RJ, Lee J, Lui LY, et al. Older Men With Anemia Have Increased Fracture Risk Independent of Bone Mineral Density. The Journal of Clinical Endocrinology & Metabolism. 2017;102(7):2199-206. doi:10.1210/jc.2017-00266.

133. Gołba A, Soral T, Młynarska A, et al. [Kinesiophobia in patients with cardiovascular disease]. Wiad Lek. 2018;71(9):1653-60.

134. Lee CT, Chen MZ, Yip CYC, et al. Prevalence of Anemia and Its Association with Frailty, Physical Function and Cognition in Community-Dwelling Older Adults: Findings from the HOPE Study. The Journal of nutrition, health and aging. 2021;25(5):679-87. doi:10.1007/s12603-021-1625-3.

135. Crawford J, Cella D, Cleeland CS, et al. Relationship between changes in hemoglobin level and quality of life during chemotherapy in anemic cancer patients receiving epoetin alfa therapy. Cancer. 2002;95(4):888-95. doi:10.1002/cncr.10763.

136. Han SV, Park M, Kwon YM, et al. Mild Anemia and Risk for All-Cause, Cardiovascular and Cancer Deaths in Apparently Healthy Elderly Koreans. Korean J Fam Med. 2019;40(3):151-8. doi:10.4082/kjfm.17.0089.

137. Penninx BWJH, Pahor M, Woodman RC, Guralnik JM. Anemia in Old Age Is Associated With Increased Mortality and Hospitalization. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. 2006;61(5):474-9. doi:10.1093/gerona/61.5.474.

138. Girelli D, Marchi G, Camaschella C. Anemia in the Elderly. HemaSphere. 2018;2(3): e40. doi:10.1097/HS9.0000000000000040

139. Goodnough LT, Schrier SL. Evaluation and management of anemia in the elderly. American J Hematol. 2014;89(1):88-96. doi:10.1002/ajh.23598.

140. Contaldo A, Losurdo G, Albano F, et al. The Spectrum of Small Intestinal Lesions in Patients with Unexplained Iron Deficiency Anemia Detected by Video Capsule Endoscopy. Medicina. 2019;55(3):59. doi:10.3390/medicina55030059.

141. Masclee GMC, Valkhoff VE, Coloma PM, et al. Risk of Upper Gastrointestinal Bleeding From Different Drug Combinations. Gastroenterology. 2014;147(4):784- 92. doi:10.1053/j.gastro.2014.06.007.

142. Wilhelm SM, Rjater RG, Kale-Pradhan PB. Perils and pitfalls of long-term effects of proton pump inhibitors. Expert Review of Clinical Pharmacology. 2013;6(4):443-51. doi:10.1586/17512433.2013.811206.

143. French JB, Pamboukian SV, George JF, et al. Gastrointestinal Bleeding in Patients with Ventricular Assist Devices Is Highest Immediately After Implantation. ASAIO Journal. 2013;59(5):480-5. doi:10.1097/MAT.0b013e3182a4b434.

144. Braz VL, Duarte YADO, Corona LP. A associação entre anemia e alguns aspectos da funcionalidade em idosos. Ciênc saúde coletiva. 2019;24(9):3257-64. doi:10.1590/1413-81232018249.21142017.

145. Xi R, Wang R, Wang Y, et al. Comparative analysis of the oral microbiota between iron-deficiency anaemia (IDA) patients and healthy individuals by high-throughput sequencing. BMC Oral Health. 2019;19(1):255. doi:10.1186/s12903-019-0947-6.

146. Drozdov VN, Noskova KK, Petrakov AN. The effectiveness of iron absorption when taken separately and simultaneously with calcium. Therapist. 2007;(9):47-51. (In Russ.)

147. Logan RPH, Walker MM. ABC of the upper gastrointestinal tract: Epidemiology and diagnosis of Helicobacter pylori infection. BMJ. 2001;323(7318):920-2. doi:10.1136/bmj.323.7318.920.

148. Bakirova AE, Alekseev DG, Partsernyak AS, Bakirov BA. Interrelation of intestinal microbiota and iron deficiency anemia. Effective pharmacotherapy. 2024;20(30):56- 62. (In Russ.) doi:10.33978/2307-3586-2024-20-30-56-62.

149. Choi G, Bessman NJ. Iron at the crossroads of host–microbiome interactions in health and disease. Nat Microbiol. 2025;10(6):1282-93. doi:10.1038/s41564-025-02001-y.

150. Soysal P, Stubbs B, Lucato P, et al. Inflammation and frailty in the elderly: A systematic review and meta-analysis. Ageing Research Reviews. 2016;31:1-8. doi:10.1016/j.arr.2016.08.006.

151. Bian AL, Hu HY, Rong YD, et al. A study on relationship between elderly sarcopenia and inflammatory factors IL-6 and TNF-α. Eur J Med Res. 2017;22(1):25. doi:10.1186/s40001-017-0266-9.

152. Rong YD, Bian AL, Hu HY, et al. Study on relationship between elderly sarcopenia and inflammatory cytokine IL-6, anti-inflammatory cytokine IL-10. BMC Geriatr. 2018;18(1):308. doi:10.1186/s12877-018-1007-9.

153. Zille De Queiroz B, De Britto Rosa NM, Pereira DS, et al. Inflammatory mediators and the risk of falls among older women with acute low back pain: data from Back Complaints in the Elders (BACE) — Brazil. Eur Spine J. 2020;29(3):549-55. doi:10.1007/s00586-019-06168-x.

154. Ng A, Tam WW, Zhang MW, et al. IL-1β, IL-6, TNF-α and CRP in Elderly Patients with Depression or Alzheimer’s disease: Systematic Review and Meta-Analysis. Sci Rep. 2018;8(1):12050. doi:10.1038/s41598-018-30487-6.

155. Franceschi C, Garagnani P, Parini P, et al. Inflammaging: a new immune–metabolic viewpoint for age-related diseases. Nat Rev Endocrinol. 2018;14(10):576-90. doi:10.1038/s41574-018-0059-4.

156. Andrès E, Serraj K, Federici L, et al. Anemia in elderly patients: New insight into an old disorder. Geriatrics Gerontology Int. 2013;13(3):519-27. doi:10.1111/ggi.12017.

157. Kaunitz J, Ganz T. AGA Clinical Practice Guidelines on the Gastrointestinal Evaluation of Iron Deficiency Anemia. Gastroenterology. 2021;161(1):362-5. doi:10.1053/j.gastro.2021.03.001.

158. Horrigan J, Tadros M, Jacob J.An Introduction to the Clinical Approach and Management of Occult Gastrointestinal Bleeding. In: M. T, G.Y W, eds. Management of Occult GI Bleeding. Clinical Gastroenterology. Humana; 2021. doi:10.1007/978-3-030-71468-0_1.

159. Rockey DC. Occult gastrointestinal bleeding. N Engl J Med. 1999;341(1):38-46. doi:10.1056/nejm199907013410107.

160. Feinman M, Haut ER. Lower Gastrointestinal Bleeding. Surgical Clinics of North America. 2014;94(1):55-63. doi:10.1016/j.suc.2013.10.005.

161. Oakland K.Acute lower GI bleeding in the UK: patient characteristics, interventions and outcomes in the first nationwide audit. Gut. 2018;67(4):654-62. doi:10.1136/gutjnl-2016-313428.

162. Bounds BC, Kelsey PB. Lower gastrointestinal bleeding. Gastrointest Endosc Clin N Am. in eng;2007;17(2):273-88, vi. doi:10.1016/j.giec.2007.03.010.

163. Brief algorithms for managing patients at the stage of primary health care. A manual for general practitioners. Edited by O.M. Drapkina. Moscow: Vidox; 2019. 20 p. (In Russ.) ISBN: 978-5-9500829-8-0.

164. Lukina EA, Ledina LV, Rogovskaya SI. Iron deficiency anemia: the view of a hematologist and gynecologist. We optimize diagnostics and treatment tactics. Breast cancer Mother and child. 2020;3(4):248-53. (In Russ.) doi:10.32364/2618-8430-2020-3-4-248-253.

165. Nikonov EL. The use of fecal tests in colorectal cancer screening programs. Doctor. ru. 2018;(3):16-22. (In Russ.)

166. Kononov AV, Mozgovoy SI, Shimanskaya AG. Lifetime pathoanatomic diagnostics of diseases of the digestive system (class XI ICD-10). Clinical recommendations. Practical medicine; 2019, 192 p. (In Russ.) ISBN: 978-5-98811-507-6.

167. Rockey DC, Koch J, Yee J, et al. Prospective comparison of air-contrast barium enema and colonoscopy in patients with fecal occult blood: a pilot study. Gastrointestinal Endoscopy. 2004;60(6):953-8. doi:10.1016/s0016-5107(04)02223-0.

168. Sengupta N, Feuerstein JD, Jairath V, et al. Management of Patients With Acute Lower Gastrointestinal Bleeding: An Updated ACG Guideline. Am J Gastroenterol. 2023;118(2):208-31. doi:10.14309/ajg.0000000000002130.

169. Parfenov AI, Bykova SV, Sabelnikova EA, et al. The All-Russian consensus on the diagnosis and treatment of celiac disease in children and adults. The Almanac of Clinical Medicine. 2016;44(6):661-8. (In Russ.) doi:10.18786/2072-0505-2016-44-6-661-688.

170. Al-Radi LS, Andreeva NE, Balakireva TV, et al. Rational pharmacotherapy of diseases of the blood system. Litterra; 2009. 688 p. (In Russ.) ISBN: 978-5-904090-05-0. EDN: QLTIPP.

171. Bounds BC, Kelsey PB. Lower Gastrointestinal Bleeding. Gastrointestinal Endoscopy Clinics of North America. 2007;17(2):273-88. doi:10.1016/j.giec.2007.03.010.

172. Stewart JG, Ahlquist DA, McGill DB, et al. Gastrointestinal blood loss and anemia in runners. Ann Intern Med. 1984;100(6):843-5. doi:10.7326/0003-4819-100-6-843.

173. Gorokhovskaya GN, Martynov AI, Yun VL, Petina MM. Modern therapist's view on the problem of iron deficiency anemia in patients with cardiovascular pathology. Medical advice. 2020;(14):70-8. (In Russ.) doi:10.21518/2079-701X-2020-14-70-78.

174. Sidoruk SP, Petrova EB, Mitkovskaya NP. Anemia in cardiovascular diseases. Emergency cardiology and cardiovascular risks. 2017;1(1):38-45. (In Russ.)

175. Astor BC, Coresh J, Heiss G. Kidney function and anemia as risk factors for coronary heart disease and mortality: the AtheroscLerosis Risk in Communities (ARIC) Study. Am Heart J. 2006;151(2):492-500. doi:10.1016/j.ahj.2005.03.055.

176. Klip IjT, Comin-Colet J, Voors AA, et al. Iron deficiency in chronic heart failure: An international pooled analysis. American Heart Journal. 2013;165(4):575-82. doi:10.1016/j.ahj.2013.01.017.

177. Jankowska EA, Kasztura M, Sokolski M. Iron deficiency defined as depleted iron stores accompanied by unmet cellular iron requirements identifies patients at the highest risk of death after an episode of acute heart failure. Eur Heart J. 2014;35:2468-76. doi:10.1093/eurheartj/ehu235.

178. Okonko DO, Mandal AK, Missouris CG, Poole-Wilson PA. Disordered iron homeostasis in chronic heart failure: Prevalence, predictors, and relation to anemia, exercise capacity, and survival. J Am Coll Cardiol. 2011;58:1241-51. doi:10.1016/j.jacc.2011.04.040.

179. Adams KF, Patterson JH, Oren RM. Prospective assessment of the occurrence of anemia in patients with heart failure: results from the Study of Anemia in a Heart Failure Population (STAMINA-HFP) Registry. Am Heart J. 2009;157:926-32. doi:10.1016/j.ahj.2009.01.012.

180. Vinogradova NG, Polyakov DS, Fomin IV. Analysis of mortality in patients with CHF after decompensation during long-term follow-up in specialized medical care and in real clinical practice. Kardiologija. 2020;60(4):91-100. (In Russ.) doi:10.18087/cardio.2020.4.n1014.

181. Jonsson A, Hallberg AC, Edner M. A comprehensive assessment of the association between anemia, clinical covariates and outcomes in a population-wide heart failure registry. Int J Cardiol. 2016;211:124-31. doi:10.1016/j.ijcard.2016.02.144.

182. Von Haehling S, Schefold JC, Majc Hodoscek L, et al. Anaemia is an independent predictor of death in patients hospitalized for acute heart failure. Clin Res Cardiol. 2010;99(2):107-13. doi:10.1007/s00392-009-0092-3.

183. Komajda M, Anker SD, Charlesworth A, et al. The impact of new onset anaemia on morbidity and mortality in chronic heart failure: results from COMET. European Heart Journal. 2006;27(12):1440-6. doi:10.1093/eurheartj/ehl012.

184. O’Meara E, Clayton T, McEntegart MB. Clinical correlates and consequences of anemia in a broad spectrum of patients with heart failure: results of the Candesartan in Heart Failure: Assessment of Reduction in Mortality and Morbidity (CHARM. Program CHARM Committees and Investigators Circulation. 2006;113(7):986-94. doi:10.1161/CIRCULATIONAHA.105.582577.

185. Kupryashov AA, Rivnyak MI. Anemia associated with circulatory insufficiency: epidemiology, pathogenesis, prognosis. Clinical physiology of blood circulation. 2020;17(3):172-82. (In Russ.) doi:10.24022/1814-6910-2020-17-3-172-182.

186. Jankowska EA, Haehling S, Anker SD. Iron deficiency and heart failure: diagnostic dilemmas and therapeutic perspectives. Eur Heart J. 2013;34:816-29. doi:10.1093/eurheartj/ehs224.

187. Enjuanes C, Klip IjT, Bruguera J, et al. Iron deficiency and health-related quality of life in chronic heart failure: Results from a multicenter European study. International Journal of Cardiology. 2014;174(2):268-75. doi:10.1016/j.ijcard.2014.03.169.

188. Kupryashov AA, Rivnyak MI, Koloskova NN, et al. Factors determining the physical performance of patients with circulatory insufficiency and anemia. Creative cardiology. 2019;13(4):349-62. (In Russ.) doi:10.24022/1997-3187-2019-13-4-349-362.

189. Núñez J, Comín-Colet J, Miñana G. Iron deficiency and risk of early readmission following a hospitalization for acute heart failure. Eur J Heart Fail. 2016;18:798-802. doi:10.1002/ejhf.513.

190. Ponikowski P, Kirwan BA, Anker SD, et al. Ferric carboxymaltose for iron deficiency at discharge after acute heart failure: a multicentre, double-blind, randomised, controlled trial. Lancet. 2020;396(10266):1895-904. doi:10.1016/S0140-6736(20)32339-4.

191. Melenovsky V, Petrak J, Mracek T, et al. Myocardial iron content and mitochondrial function in human heart failure: a direct tissue analysis. European J of Heart Fail. 2017;19(4):522-30. doi:10.1002/ejhf.640.

192. Kupryashov AA, Rivnyak MI. Hypoxia and iron deficiency: synergistic effects on the body. Clinical physiology of blood circulation. 2022;19(1):57-69. (In Russ.) doi:10.24022/1814-6910-2022-19-1-57-69.

193. Turner LR, Premo DA, Gibbs BJ. Adaptations to iron deficiency: cardiac functional responsiveness to norepinephrine, arterial remodeling, and the effect of beta-blockade on cardiac hypertrophy. BMC Physiol. 2002;2:1. doi:10.1186/1472-6793-2-1.

194. Naito Y, Tsujino T, Matsumoto M, et al. Adaptive response of the heart to longterm anemia induced by iron deficiency. American Journal of Physiology-Heart and Circulatory Physiology. 2009;296(3):H585-H593. doi:10.1152/ajpheart.00463.2008.

195. Dong F, Zhang X, Culver B, et al. Dietary iron deficiency induces ventricular dilation, mitochondrial ultrastructural aberrations and cytochrome c release: involvement of nitric oxide synthase and protein tyrosine nitration. Clinical Science. 2005;109(3):277- 86. doi:10.1042/CS20040278.

196. Tang YD, Katz SD. The prevalence of anemia in chronic heart failure and its impact on the clinical outcomes. Heart Fail Rev. 2008;13:387-92. doi:10.1007/s10741-008-9089-7.

197. Ezekowitz JA, McAlister FA, Armstrong PW. Anemia is common in heart failure and is associated with poor outcomes: insights from a cohort of 12065 patients with new-onset heart failure. Circulation. 2003;107:223-5. doi:10.1161/01.cir.0000052622.51963.fc.

198. Anand IS, Kuskowski MA, Rector TS, et al. Anemia and change in hemoglobin over time related to mortality and morbidity in patients with chronic heart failure: results from Val-HeFT. Circulation. 2005;112:1121-7. doi:10.1161/CIRCULATIONAHA.104.512988.

199. Rocha BML, Cunha GJL, Menezes Falcão LF. The Burden of Iron Deficiency in Heart Failure. Journal of the American College of Cardiology. 2018;71(7):782-93. doi:10.1016/j.jacc.2017.12.027.

200. Mareev VY, Gilyarevsky SR, Mareev YV, et al. The agreed opinion of experts on the role of iron deficiency in patients with chronic heart failure, as well as on modern approaches to its correction. Kardiologija. 2020;60(1):99-106. (In Russ.) doi:10.18087/cardio.2020.1.n961.

201. Mistry RH, Kohut A, Ford P.Correction of iron deficiency in hospitalized heart failure patients does not improve patient outcomes. Annals of Hematology. 2020;100(3):661- 6. doi:10.1007/s00277-020-04338-2.

202. Cohen-Solal A.Diagnosis and treatment of iron deficiency in patients with heart failure: expert position paper from French cardiologists. Arch Cardiovasc Dis. 2014;107:563-71. doi:10.1016/j.acvd.2014.07.049.

203. Anand IS, Gupta P. Anemia and Iron Deficiency in Heart Failure. Circulation. 2018; 138(1):80-98. doi:10.1161/CIRCULATIONAHA.118.030099.

204. Weiss G, Goodnough LT. Anemia of Chronic Disease. N Engl J Med. 2005;352(10): 1011-23. doi:10.1056/NEJMra041809.

205. Von Haehling S, Jankowska EA, Van Veldhuisen DJ, et al. Iron deficiency and cardiovascular disease. Nat Rev Cardiol. 2015;12(11):659-69. doi:10.1038/nrcardio.2015.109.

206. McDonagh TA, Metra M, Adamo M, et al. 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure. European Heart Journal. 2021;42(36):3599-726. doi:10.1093/eurheartj/ehab368.

207. Grote Beverborg N, Klip IjT, Meijers WC, et al. Definition of Iron Deficiency Based on the Gold Standard of Bone Marrow Iron Staining in Heart Failure Patients. Circ: Heart Failure. 2018;11(2):e004519. doi:10.1161/CIRCHEARTFAILURE.117.004519.

208. Jankowska EA, Wojtas K, Kasztura M, et al. Bone marrow iron depletion is common in patients with coronary artery disease. International Journal of Cardiology. 2015;182:517-22. doi:10.1016/j.ijcard.2014.10.006.

209. Mleczko-Sanecka K, Silva AR, Call D. Imatinib and spironolactone suppress hepcidin expression. Haematologica. 2017;102:1173-84. doi:10.3324/haematol.2016.162917.

210. Lewis GD, Malhotra R, Hernandez AF. Effect of Oral Iron Repletion on Exercise Capacity in Patients with Heart Failure with Reduced Ejection Fraction and Iron Deficiency: the IRONOUT HF Randomized Clinical Trial. for the NHLBI Heart Failure Clinical Research Network JAMA. 2017;317(19):1958-66. doi:10.1001/jama.2017.5427.

211. Anker SD, Comin Colet J, Filippatos G. FAIR-HF Trial Investigators. Ferric carboxymaltose in patients with heart failure and iron deficiency. N Engl J Med. 2009; 361:2436-48. doi:10.1056/NEJMoa0908355.

212. Veldhuisen DJ, Ponikowski P, Meer P. EFFECT-HF Investigators. Effect of ferric carboxymaltose on exercise capacity in patients with chronic heart failure and iron deficiency. Circulation. 2017;136:1374-83. doi:10.1161/CIRCULATIONAHA.117.027497.

213. Filippatos G, Farmakis D, Colet JC. Intravenous ferric carboxymaltose in iron-deficient chronic heart failure patients with and without anaemia: a subanalysis of the FAIR-HF trial. Eur J Heart Fail. 2013;15:1267-76. doi:10.1093/eurjhf/hft099.

214. Jankowska EA, Tkaczyszyn M, Suchocki T, et al. Effects of intravenous iron therapy in iron-deficient patients with systolic heart failure: a meta-analysis of randomized controlled trials. European J of Heart Fail. 2016;18(7):786-95. doi:10.1002/ejhf.473.

215. Anker SD, Kirwan BA, Veldhuisen DJ. Effects of ferric carboxymaltose on hospitalisations and mortality rates in iron-deficient heart failure patients: an individual patient data meta-analysis. Eur J Heart Fail. 2018;20:125-33. doi:10.1002/ejhf.823.

216. Kalra PR, Cleland JGF, Petrie MC, et al. Intravenous ferric derisomaltose in patients with heart failure and iron deficiency in the UK (IRONMAN): an investigatorinitiated, prospective, randomised, open-label, blinded-endpoint trial. The Lancet. 2022;400(10369):2199-209. doi:10.1016/s0140-6736(22)02083-9.

217. McDonagh TA, Metra M, Adamo M, et al. 2023 Focused Update of the 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure. European Heart Journal. 2023;44(37):3627-39. doi:10.1093/eurheartj/ehad195.

218. Minhas AMK, Sagheer S, Shekhar R, et al. Trends and Inpatient Outcomes of Primary Atrial Fibrillation Hospitalizations with Underlying Iron Deficiency Anemia: An Analysis of The National Inpatient Sample Database from 2004–2018. Current Problems in Cardiology. 2022;47(10):101001. doi:10.1016/j.cpcardiol.2021.101001.

219. Groenveld HF, Januzzi JL, Damman K, et al. Anemia and Mortality in Heart Failure Patients. Journal of the American College of Cardiology. 2008;52(10):818-27. doi:10.1016/j.jacc.2008.04.061.

220. Mehdi U, Toto RD. Anemia, diabetes, and chronic kidney disease. Diabetes Care. 2009;32:1320-6. doi:10.2337/dc08-0779.

221. Tu SJ, Hanna-Rivero N, Elliott AD. Associations of anemia with stroke, bleeding, and mortality in atrial fibrillation: a systematic review and meta-analysis. J Cardiovasc Electrophysiol. 2021;32:686-94. doi:10.1111/jce.14898.

222. Xu D, Murakoshi N, Sairenchi T, et al. Anemia and Reduced Kidney Function as Risk Factors for New Onset of Atrial Fibrillation (from the Ibaraki Prefectural Health Study). The American Journal of Cardiology. 2015;115(3):328-333. doi:10.1016/j.amjcard.2014.10.041.

223. Takabayashi K, Unoki T, Ogawa H, et al. Clinical characteristics of atrial fibrillation patients with anemia: from the Fushimi AF registry. European Heart Journal. 2013;34(suppl 1):P389-P389. doi:10.1093/eurheartj/eht307.P389.

224. Sharma S, Gage BF, Deych E, Rich MW. Anemia: An independent predictor of death and hospitalizations among elderly patients with atrial fibrillation. Am Heart J. 2009;157:1057-63. doi:10.1016/j.ahj.2009.03.009.

225. An Y, Ogawa H, Esato M. Cardiovascular Events and Mortality in Patients With Atrial Fibrillation and Anemia (from the Fushimi AF Registry. Registry Investigators Am J Cardiol. 2020;134:74-82. doi:10.1016/j.amjcard.2020.08.009.

226. Kim M, Hong M, Kim JY. Clinical relationship between anemia and atrial fibrillation recurrence after catheter ablation without genetic background. Int J Cardiol Heart Vasc. 2020;27(100507). doi:10.1016/j.ijcha.2020.100507.

227. Ali AN, Athavale NV, Abdelhafiz AH. Anemia: An Independent Predictor Of Adverse Outcomes In Older Patients With Atrial Fibrillation. J Atr Fibrillation. 2016;8(6):1366. doi:10.4022/jafib.1366.

228. Goodnough LT, Nemeth E, Ganz T. Detection, evaluation, and management of ironrestricted erythropoiesis. Blood. 2010;116:4754-61. doi:10.1182/blood-2010-05-286260.

229. Keskin M, Ural D, Altay S, et al. Iron deficiency and hematinic deficiencies in atrial fibrillation: A new insight into comorbidities. Turk Kardiyol Dern Ars. 2018;46(2):103- 10. doi:10.5543/tkda.2018.51001.

230. He S, Feng R, Xu Z. Digoxin-induced anemia among patients with atrial fibrillation and heart failure: clinical data analysis and drug-gene interaction network. Oncotarget. 2017;8(34):57003-11. doi:10.18632/oncotarget.18504.

231. Tu SJ, Elliott AD, Hanna-Rivero N, et al. Rationale and design of the IRON-AF study: a double-blind, randomised, placebo-controlled study to assess the effect of intravenous ferric carboxymaltose in patients with atrial fibrillation and iron deficiency. BMJ Open. 2021;11(8):e047642. doi:10.1136/bmjopen-2020-047642.

232. Simion AYu, Ovsyannikov EU, Simion KA. The relationship between iron deficiency anemia and the severity of coronary heart disease at the stage of primary health care. Cardiovascular therapy and prevention. 2024;23(S6):20-1. (In Russ.)

233. Borsukov SA, Dolgaya MI, Perevozchikova ED, Kozyrev OA. Anemia in patients with coronary artery disease. Smolensk medical Almanac. 2023;(2):44-7. (In Russ.) doi:10.37903/SMA.2023.2.13.

234. Chizhova MA, Bolkhovitina OA, Sovenko GN, et al. Evaluation of the effectiveness of iron preparations in elderly patients suffering from coronary heart disease and iron deficiency anemia. Scientific Bulletin of Belgorod State University Series: Medicine Pharmacy. 2011;(4-1):91-4. (In Russ.)

235. Andreenko IM, Lukyanov MM, Yakushin SS, et al. Patients with early development of cardiovascular diseases in outpatient practice: age and gender characteristics, comorbidity, drug treatment and outcomes (data from the REQUAZA registry). Cardiovascular Therapy and Prevention. 2019;18(6):99-106. (In Russ.) doi:10.15829/1728-8800-2019-6-99-106.

236. Vinogradova NG, Chesnikova AI. Iron deficiency conditions in cardiovascular diseases: impact on prognosis and correction features. South-Russian Journal of Therapeutic Practice. 2023;4(1):7-18. (In Russ.) doi:10.21886/2712-8156-2023-4-1-7-18.

237. Savarese G, Von Haehling S, Butler J, et al. Iron deficiency and cardiovascular disease. European Heart Journal. 2023;44(1):14-27. doi:10.1093/eurheartj/ehac569.

238. Corradi F, Masini G, Bucciarelli T, De Caterina R. Iron deficiency in myocardial ischaemia: molecular mechanisms and therapeutic perspectives. Cardiovascular Research. 2023;119(14):2405-20. doi:10.1093/cvr/cvad146.

239. Packer M, Anker SD, Butler J, et al. Identification of three mechanistic pathways for iron-deficient heart failure. European Heart Journal. 2024;45(26):2281-93. doi:10.1093/eurheartj/ehae284.

240. Reinhold J, Papadopoulou C, Baral R, Vassiliou VS. Iron deficiency for prognosis in acute coronary syndrome — A systematic review and meta-analysis. International Journal of Cardiology. 2021;328:46-54. doi:10.1016/j.ijcard.2020.12.021.

241. Auerbach M, Spivak J. Treatment of Iron Deficiency in the Elderly. Clinics in Geriatric Medicine. 2019;35(3):307-17. doi:10.1016/j.cger.2019.03.003.

242. Rimon E, Kagansky N, Kagansky M, et al. Are we giving too much iron? Lowdose iron therapy is effective in octogenarians. The American Journal of Medicine. 2005;118(10):1142-7. doi:10.1016/j.amjmed.2005.01.065.

243. Geisser P, Burckhardt S. The pharmacokinetics and pharmacodynamics of iron preparations. Pharmaceutics. 2011;3(1):12-33. doi:10.3390/pharmaceutics3010012.

244. Neiser S, Koskenkorva T, Schwarz K, et al. Assessment of Dextran Antigenicity of Intravenous Iron Preparations with Enzyme-Linked Immunosorbent Assay (ELISA). IJMS. 2016;17(7):1185. doi:10.3390/ijms17071185.

245. Strutynsky AV. Diagnosis and treatment of iron deficiency anemia. Breast cancer Medical review. 2014;11(22):839. (In Russ.)

246. Alleyne M, Horne MK, Miller JL. Individualized Treatment for Iron-deficiency Anemia in Adults. The American Journal of Medicine. 2008;121(11):943-8. doi:10.1016/j.amjmed.2008.07.012.

247. DeLoughery TG. Microcytic Anemia. N Engl J Med. 2014;371(14):1324-31. doi:10.1056/NEJMra1215361.

248. Lundqvist H, Sjöberg F. Food interaction of oral uptake of iron / a clinical trial using 59Fe. Arzneimittelforschung. 2007;57(6A):401-16. doi:10.1055/s-0031-1296689.

249. Crichton RR. Iron Therapy — With Special Emphasis on Intravenous Administration. 4th ed. UNI-MED Verlag; 2008.

250. Lam JR, Schneider JL, Quesenberry CP, Corley DA. Proton Pump Inhibitor and Histamine-2 Receptor Antagonist Use and Iron Deficiency. Gastroenterology. 2017; 152(4):821-29. doi:10.1053/j.gastro.2016.11.023.

251. DeLoughery TG, Jackson CS, Ko CW, Rockey DC. AGA Clinical Practice Update on Management of Iron Deficiency Anemia: Expert Review. Clinical Gastroenterology and Hepatology. 2024;22(8):1575-83. doi:10.1016/j.cgh.2024.03.046.

252. Bazeley JW, Wish JB. Recent and Emerging Therapies for Iron Deficiency in Anemia of CKD: A Review. American Journal of Kidney Diseases. 2022;79(6):868-76. doi:10.1053/j.ajkd.2021.09.017.

253. Camaschella C. Iron-deficiency anemia. N Engl J Med. 2015;372(19):1832-43. doi:10.1056/NEJMra1401038.

254. Litton E, Xiao J, Ho KM. Safety and efficacy of intravenous iron therapy in reducing requirement for allogeneic blood transfusion: systematic review and meta-analysis of randomised clinical trials. BMJ. 2013;347(aug15 1):f4822-f4822. doi:10.1136/bmj.f4822.

255. Shah AA, Donovan K, Seeley C, et al. Risk of Infection Associated With Administration of Intravenous Iron: A Systematic Review and Meta-analysis. JAMA Netw Open. 2021;4(11):e2133935. doi:10.1001/jamanetworkopen.2021.33935.

256. Horl WH, Vanrenterghem Y, Aljama P, et al. OPTA: Optimal treatment of anaemia in patients with chronic kidney disease (CKD). Nephrology Dialysis Transplantation. 2007;22(Supplement 3):iii20-iii26. doi:10.1093/ndt/gfm017.

257. Moiseev SV. Iron carboxymaltosate (Ferinject) is a new intravenous drug for the treatment of iron deficiency anemia. Clinical pharmacology and therapy. 2012;21(2): 48-53. (In Russ.)

258. Wolf M, Chertow GM, Macdougall IC, et al. Randomized trial of intravenous ironinduced hypophosphatemia. JCI Insight. 2018;3(23):e124486. doi:10.1172/jci.insight.124486.

259. Schaefer B, Würtinger P, Finkenstedt A, et al. Choice of High-Dose Intravenous Iron Preparation Determines Hypophosphatemia Risk. Pantopoulos K, ed. PLoS ONE. 2016;11(12):e0167146. doi:10.1371/journal.pone.0167146.

260. Klein K, Asaad S, Econs M, Rubin JE. Severe FGF23-based hypophosphataemic osteomalacia due to ferric carboxymaltose administration. BMJ Case Rep. 2018;2018:bcr2017222851. doi:10.1136/bcr-2017-222851.

261. Huang LL, Lee D, Troster SM, et al. A controlled study of the effects of ferric carboxymaltose on bone and haematinic biomarkers in chronic kidney disease and pregnancy. Nephrol Dial Transplant. 2018;33(9):1628-35. doi:10.1093/ndt/gfx310.

262. Auerbach M, Deloughery T. Single-dose intravenous iron for iron deficiency: a new paradigm. Hematology. 2016;2016(1):57-66. doi:10.1182/asheducation-2016.1.57.

263. Auerbach M, Ballard H. Clinical Use of Intravenous Iron: Administration, Efficacy, and Safety. Hematology. 2010;2010(1):338-47. doi:10.1182/asheducation-2010.1.338.

264. Rampton D, Folkersen J, Fishbane S, et al. Hypersensitivity reactions to intravenous iron: guidance for risk minimization and management. Haematologica. 2014;99(11): 1671-6. doi:10.3324/haematol.2014.111492.

265. Auerbach M, Ballard H, Glaspy J. Clinical update: intravenous iron for anaemia. The Lancet. 2007;369(9572):1502-4. doi:10.1016/S0140-6736(07)60689-8.

266. Marx JJM. Iron and infection: competition between host and microbes for a precious element. Best Pract Res Clin Haematol. 2002;15(2):411-26.

267. Muñoz M, Laso-Morales MJ, Gómez-Ramírez S, et al. Pre-operative haemoglobin levels and iron status in a large multicentre cohort of patients undergoing major elective surgery. Anaesthesia. 2017;72(7):826-34. doi:10.1111/anae.13840

268. Muñoz M, Gõmez-Ramírez S, Cuenca J, et al. Very-short-term perioperative intravenous iron administration and postoperative outcome in major orthopedic surgery: A pooled analysis of observational data from 2547 patients. Transfusion. 2014;54(2): 289-99. doi:10.1111/trf.12195

269. Fowler AJ, Ahmad T, Phull MK, Allard S, Gillies MA, Pearse RM. Meta-analysis of the association between preoperative anaemia and mortality after surgery. Br J Surg. 2015;102(11):1314-24. doi:10.1002/bjs.9861

270. Kupryashov AA, Kuksina EV, Kicheva GA. The effect of preoperative anemia and transfusions of allogeneic erythrocytes on the results of surgical treatment of patients with heart valve defects: pseudorandomization. Thoracic and cardiovascular surgery. 2025;67(1):67-78. (In Russ.) doi:10.24022/0236-2791-2025-67-1-67-78

271. Kupryashov AA, Kuksina EV, Kicheva GA, Haidarov GA. The effect of anemia on the results of myocardial revascularization performed under conditions of artificial circulation. Kardiologija. 2021;61(11):42-8. (In Russ.)

272. Muñoz M, Acheson AG, Auerbach M, et al. International consensus statement on the peri-operative management of anaemia and iron deficiency. Anaesthesia. 2017;72(2):233-247. doi:10.1111/anae.13773.

273. Kupryashov AA, Samuilova OV, Samuilova DS. Careful treatment of the patient's blood as a priority strategy in cardiac surgery. Hematology and transfusiology. 2021;66(3):395-416. (In Russ.) doi:10.35754/0234-5730-2021-66-3-395-416.

274. Rogers BA, Cowie A, Alcock C, Rosson JW. Identification and treatment of anaemia in patients a waiting hip replacement. Ann R Coll Surg Engl. 2008;90(6):504-7. doi:10.1308/003588408X301163.

275. González-Pérez A, Al-Sibai JZ, Álvarez-Fernández P, et al. Liberal red blood cell transfusions impair quality of life after cardiac surgery. Med Intensiva (Engl Ed). 2019;43(3):156-64. English, Spanish. doi:10.1016/j.medin.2018.01.014.

276. Acheson AG, Brookes MJ, Spahn DR. Effects of allogeneic red blood cell transfusions on clinical outcomes in patients undergoing colorectal cancer surgery: A systematic review and meta-analysis. Ann Surg. 2012;256(2):235-44. doi:10.1097/SLA.0b013e31825b35d5.

277. Salpeter SR, Buckley JS, Chatterjee S. Impact of more restrictive blood transfusion strategies on clinical outcomes: A meta-analysis and systematic review. Am J Med. 2014;127(2):124-131.e3. doi:10.1016/j.amjmed.2013.09.017.

278. Zhou X, Xu Z, Wang Y, Sun L, Zhou W, Liu X. Association between storage age of transfused red blood cells and clinical outcomes in critically ill adults: A meta-analysis of randomized controlled trials. Med Intensiva (Engl Ed). 2019;43(9):528-537. English, Spanish. doi:10.1016/j.medin.2018.07.004.

279. Muñoz M, Gómez-Ramírez S, Kozek-Langeneker S, et al. "Fit to fly": Overcoming barriers to preoperative haemoglobin optimization in surgical patients. Br J Anaesth. 2015;115(1):15-24. doi:10.1093/bja/aev165.

280. Rosencher N, Kerkkamp HEM, Macheras G, et al. Orthopedic surgery transfusion hemoglobin european overview (OSTHEO) study: Blood management in elective knee and hip arthroplasty in Europe. Transfusion. 2003;43(4):459-69. doi:10.1046/j.1537-2995.2003.00348.x.

281. Gombotz H, Rehak PH, Shander A, Hofmann A. Blood use in elective surgery: The Austrian benchmark study. Transfusion. 2007;47(8):1468-80. doi:10.1111/j.1537-2995.2007.01286.x.

282. Moretti D, Goede JS, Zeder C, et al. Oral iron supplements increase hepcidin and decrease iron absorption from daily or twice-daily doses in iron-depleted young women. Blood. 2015 2;126(17):1981-9. doi:10.1182/blood-2015-05-642223.

283. Rimon E, Kagansky N, Kagansky M, et al. Are we giving too much iron? Low-dose iron therapy is effective in octogenarians. Am J Med. 2005;118(10):1142-7. doi:10.1016/j.amjmed.2005.01.065.

284. Calleja JL, Delgado S, del Val A, et al. Ferric carboxymaltose reduces transfusions and hospital stay in patients with colon cancer and anemia. Int J Colorectal Dis. 2016;31(3):543-51. doi:10.1007/s00384-015-2461-x.

285. Keeler BD, Simpson JA, Ng O, et al. IVICA Trial Group. Randomized clinical trial of preoperative oral versus intravenous iron in anaemic patients with colorectal cancer. Br J Surg. 2017;104(3):214-21. doi:10.1002/bjs.10328.

286. Gómez Ramírez S, Remacha Sevilla ÁF, Muñoz Gómez M. Anaemia in the elderly. Med Clin (Barc). 2017;149(11):496-503. English, Spanish. doi:10.1016/j.medcli.2017.06.025.

287. Weltert L, Rondinelli B, Bello R, et al. A single dose of erythropoietin reduces perioperative transfusions in cardiac surgery: Results of a prospective single-blind randomized controlled trial. Transfusion. 2015;55(7):1644-54. doi:10.1111/trf.13027.

288. Yoo YC, Shim JK, Kim JC, et al. Effect of single recombinant human erythropoietin injection on transfusion requirements in preoperatively anemic patients undergoing valvular heart surgery. Anesthesiology. 2011;115(5):929-37. doi:10.1097/ALN.0b013e318232004b.

289. NBA (National Blood Authority). Patient Blood Management Guidelines: Module 2-Perioperative. 168 p. ISBN: 978-0-9775298-7-2.

290. Shander A, Knight K, Thurer R, et al. Prevalence and outcomes of anemia in surgery: a systematic review of the literature. Am J Med. 2004;116 Suppl 7A:58S-69S. doi: 10.1016/j.amjmed.2003.12.013.

291. Muñoz M, García-Erce JA, Remacha ÁF. Disorders of iron metabolism. Part II: Iron deficiency and iron overload. J Clin Pathol. 2011;64(4):287-96. doi:10.1136/jcp.2010.086991.

292. Leal-Noval SR, Muñoz M, Asuero M, et al. Spanish Expert Panel on Alternatives to Allogeneic Blood Transfusion. Spanish Consensus Statement on alternatives to allogeneic blood transfusion: the 2013 update of the "Seville Document". Blood Transfus. 2013;11(4):585-610. doi:10.2450/2013.0029-13.

293. Muñoz M, Naveira E, Seara J, Cordero J. Effects of postoperative intravenous iron on transfusion requirements after lower limb arthroplasty. Br J Anaesth. 2012; 108(3):532-4. doi:10.1093/bja/aes012.

294. Yoon HM, Kim YW, Nam BH, et al. Intravenous iron supplementation may be superior to observation in acute isovolemic anemia after gastrectomy for cancer. World J Gastroenterol. 2014;20(7):1852-7. doi:10.3748/wjg.v20.i7.1852.

295. Seid MH, Derman RJ, Baker JB, et al. Ferric carboxymaltose injection in the treatment of postpartum iron deficiency anemia: a randomized controlled clinical trial. Am J Obstet Gynecol. 2008;199(4):435.e1-7. doi:10.1016/j.ajog.2008.07.046.

296. Khalafallah AA, Yan C, Al-Badri R, et al. Intravenous ferric carboxymaltose versus standard care in the management of postoperative anaemia: a prospective, open-label, randomised controlled trial. Lancet Haematol. 2016;3(9):e415-25. doi:10.1016/S2352-3026(16)30078-3.

297. Bisbe E, Moltó L, Arroyo R, et al. Randomized trial comparing ferric carboxymaltose vs oral ferrous glycine sulphate for postoperative anaemia after total knee arthroplasty. British Journal of Anaesthesia. 2014;113(3):402-9. doi:10.1093/bja/aeu092.

298. Kim YW, Bae JM, Park YK. Effect of Intravenous Ferric Carboxymaltose on Hemoglobin Response Among Patients With Acute Isovolemic Anemia Following Gastrectomy: The FAIRY Randomized Clinical Trial. JAMA. 2017;317(20):2097-104. doi:10.1001/jama.2017.5703.

299. Golukhova EZ, Kupryashov AA, Khicheva GA, et al. Assessment of the socioeconomic benefits of introducing patient blood management into the practice of surgical interventions for coronary heart disease (I20-I25). Kardiologija. 2021;61(3):77-86. (In Russ.)

300. Zhiburt EB, Madzaev SR, Shestakov EA. Patient Blood Management. Vol 121. (2nd edition, ed.). N.I. Pirogov National Medical and Surgical Center. 2021. (In Russ.)

301. Zhiburt EB. Pediatric Transfusiology. Vol 344. Geotar-Media. 2023. (In Russ.)

302. Chouraqui JP. Dietary Approaches to Iron Deficiency Prevention in Childhood — A Critical Public Health Issue. Nutrients. 2022;14(8):1604. doi:10.3390/nu14081604.

303. Cohen CT, Powers JM. Nutritional Strategies for Managing Iron Deficiency in Adolescents: Approaches to a Challenging but Common Problem. Advances in Nutrition. 2024;15(5):100215. doi:10.1016/j.advnut.2024.100215.

304. Da Silva Lopes K, Yamaji N, Rahman MdO, et al. Nutrition-specific interventions for preventing and controlling anaemia throughout the life cycle: an overview of systematic reviews. Cochrane Developmental, Psychosocial and Learning Problems Group, ed. Cochrane Database of Systematic Reviews. 2021;2022(1). doi:10.1002/14651858.CD013092.pub2.

305. Skolmowska D, Głąbska D, Kołota A, Guzek D. Effectiveness of Dietary Interventions to Treat Iron-Deficiency Anemia in Women: A Systematic Review of Randomized Controlled Trials. Nutrients. 2022;14(13):2724. doi:10.3390/nu14132724.

306. Lopez De Romaña D, Mildon A, Golan J, et al. Review of intervention products for use in the prevention and control of anemia. Annals of the New York Academy of Sciences. 2023;1529(1):42-60. doi:10.1111/nyas.15062.

307. Pasricha SR, Drakesmith H, Black J, et al. Control of iron deficiency anemia in low- and middle-income countries. Blood. 2013;121(14):2607-17. doi:10.1182/blood-2012-09-453522.

308. EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA), Turck D, Bohn T, et al. Scientific opinion on the tolerable upper intake level for iron. EFS2. 2024;22(6). doi:10.2903/j.efsa.2024.8819.

309. Pineda O, Ashmead HD. Effectiveness of treatment of iron-deficiency anemia in infants and young children with ferrous bis-glycinate chelate. Nutrition. 2001;17(5):381-4. doi:10.1016/S0899-9007(01)00519-6.

310. Ferrari P, Nicolini A, Manca ML, et al. Treatment of mild non-chemotherapyinduced iron deficiency anemia in cancer patients: Comparison between oral ferrous bisglycinate chelate and ferrous sulfate. Biomedicine & Pharmacotherapy. 2012;66(6):414-8. doi:10.1016/j.biopha.2012.06.003.

311. Fischer JAJ, Cherian AM, Bone JN, Karakochuk CD. The effects of oral ferrous bisglycinate supplementation on hemoglobin and ferritin concentrations in adults and children: a systematic review and meta-analysis of randomized controlled trials. Nutrition Reviews. 2023;81(8):904-20. doi:10.1093/nutrit/nuac106.

312. Bakirov BA, Nagaev IR, Donskov SV. Nutritional correction of iron metabolism status in women of reproductive age: results of an open prospective post-marketing study with active control in parallel groups. Cardiosomatics. 2025;16(1):62-75. (In Russ.) doi:10.17816/CS677071.

313. Iolascon A, Andolfo I, Russo R, et al. Recommendations for diagnosis, treatment, and prevention of iron deficiency and iron deficiency anemia. HemaSphere. 2024;8(7): e108. doi:10.1002/hem3.108.

314. Drapkina OM, Avalueva EB, Bakulin IG, et al. Management of patients with iron deficiency anemia at the stage of primary health care. Practical guide. M.: ROPNIZ, LLC "Silicea-Polygraph", 2022, 88 p. (In Russ.) ISBN: 978-5-6046966- 3-7 doi:10.15829/ROPNIZ-zda-2022. EDN: TKORUS.